Phenotypic clusters of narcolepsy type 1: Insights from age of onset, weight gain, sleep patterns, and impulsivity.

Objective: This study aimed to discern the underlying relationships between clinical manifestations and neuroimaging phenotypes among patients with narcolepsy type 1 (NT1).

Methods: Demographic characteristics, clinical manifestations, polysomnography parameters, and comorbidities were collected in 158 NT1 patients. Using R software, we applied k-medoid cluster analysis to create homogenous NT1 patient clusters.

A high arousal threshold is associated with nocturnal gastroesophageal reflux in obstructive sleep apnea.

Objective: Nocturnal gastroesophageal reflux (nGER) was reported to be associated with obstructive sleep apnea (OSA). However, pathophysiological traits in OSA patients with nGER were poorly understood, and arousal threshold (ArTH) might play an important role in this relationship. This study aimed to identify the clinical characteristics of patients with OSA comorbid with nGER, and investigate the association between ArTH and nGER in patients with OSA.

Structure-property relationships in fibrous meniscal tissue through image-based augmentation.

This study introduces an adaptive three-dimensional (3D) image synthesis technique for creating variational realizations of fibrous meniscal tissue microstructures. The method allows controlled deviation from original geometries by modifying parameters such as porosity, pore size and specific surface area of image patches. The unbiased reconstructed samples matched the morphological and hydraulic properties of original tissues, with relative errors generally below 10%.

Central sleep apnea caused by low dosage of baclofen: a case report.

Background: Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However, the expansion use has led to an increase in baclofen-associated complications.

Global burden and future trends of metabolic dysfunction-associated Steatotic liver disease: 1990-2021 to 2045.

Introduction And Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly non-alcoholic fatty liver disease, is a growing global health challenge. This study examines the global burden of MASLD from 1990 to 2021 and projects data for 2045.

Materials And Methods: Using data from the Global Burden of Disease (GBD) Study 2021, the study analyzed MASLD across 204 countries from 1990 to 2021, focusing on prevalence, incidence, deaths, and disability-adjusted life years (DALYs).

Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis.

To develop novel PI4KIIIβ inhibitors and explore their antitumor activity, a series of 5-phenylthiazol-2-amine derivatives were synthesized by structural modifications of PIK93. Biological assay results indicated that compounds and exhibited superior PI4KIIIβ selective inhibitory and antiproliferative activity than PIK93. Mechanistic studies revealed that the two compounds inhibit the PI3K/AKT pathway more effectively, thereby inducing cancer cell apoptosis, cycle arrest in the G/M phase and autophagy.

Awakening to sleep: Sixteen years of World Sleep Day global initiatives and future directions.

World Sleep Day is an international campaign to raise public awareness of sleep health. Since 2008, the WSD campaign has grown from a small group of advocates to include hundreds of volunteer organizers in over 70 countries. A historical database of 2047 World Sleep Day (WSD) awareness activities recorded over 16 years was examined to characterize the growth of WSD and to delineate areas for further development.

Novel perspective of 'poor sleep' in public health: a narrative review.

A high percentage of people worldwide complain of sleep disturbances; however, the vast majority do not meet the diagnostic criteria for insomnia or other classic sleep disorders. Therefore, the 'classical' concept of remains undetected, and patients stay ignored and unidentified. Also, has been strongly associated with increased daytime function impairment, morbidity and mortality and is considered a risk factor for developing mental disorders.

Comprehensive analysis of the multifaceted role of ITGAV in digestive system cancer progression and immune infiltration.

Background: Digestive system cancers are among the most common malignancies, exhibiting consistently high incidence and mortality rates, yet effective detection and treatment targets remain limited. Integrin αv (ITGAV, CD51) is a significant member of the integrin family, widely recognized for its role in mediating interactions between cells and the extracellular matrix, as well as intracellular signaling. In recent years, ITGAV has been found to have significantly elevated expression in multiple tumors, such as prostate cancer, breast cancer, and osteosarcoma, and was considered to be a key component in various stages of tumor progression.

Unveiling Ultrafast Vibration Detection from Nanostructures: Cluster Arrays Achieving Precise Responses without Direct Interparticle Mechanical Interaction.

Sensitive materials assembled with nanostructures respond to subjected mechanical stimuli by modulating the internal electron transport through their intrinsic deformation. However, this deformation inherently entails a sufficient delay to overcome mechanical interactions between nanostructures to propagate within materials, thereby limiting the timely responsiveness of sensitive materials to ultrafast mechanical stimuli. Here, we propose a novel sensing array composed of isolated clusters, where majority of the clusters maintain nanoscale separations from each other.

Chromatin accessibility and differentially expressed genes profiling in large yellow croaker () head kidney cells following iridovirus infection.

Introduction: The large yellow croaker iridovirus (LYCIV) poses a significant threat to the aquaculture industry of . Understanding the host defense response to LYCIV infection is crucial for developing effective strategies to mitigate its impact.

Methods: In this study, an epigenetic approach was employed to investigate dynamic changes in chromatin accessibility using the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq).

Family misfortune caused by hereditary bias: a reflection on mitochondrial disease diagnosis in a family.

Aim: Assisted reproductive technology (ART) is an invaluable strategy for preventing the inheritance of genetic disorders and promoting the birth of healthy children. Nevertheless, the general public's limited understanding of genetics and low awareness of available services obstruct effective utilization of genetic counseling. Our analysis of a family affected by mitochondrial genetic disease aims to improve public understanding of genetic knowledge and the importance of genetic counseling.

Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.

Sjögren's syndrome (SS) is a chronic autoimmune disorder that primarily affects the exocrine glands. Due to the intricate nature of the disease progression, the exact mechanisms underlying SS are not completely understood. Recent research has highlighted the complex interplay between immune dysregulation and metabolic abnormalities in inflammatory diseases.

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.

Purpose: The purpose of this study was to investigate the role of LRRK2 in the inflammatory response to fungal keratitis (FK) and elucidate the underlying mechanisms.

Methods: The protein levels of leucine-rich repeat kinase 2 (LRRK2), p-LRRK2, and stimulator of interferon genes (STING)-related proteins were assessed by western blot analysis. ELISA and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to evaluate the inflammatory response induced by Aspergillus fumigatus.

Alcohol-induced C/EBP β-driven VIRMA decreases oxidative stress and promotes pancreatic ductal adenocarcinoma growth and metastasis via the m6A/YTHDF2/SLC43A2 pathway.

N6-methyladenosine (m6A) plays a role in the development of tumors. However, the specific role of VIRMA, an RNA methyltransferase, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study shows that VIRMA expression is elevated in PDAC.

Association between snoring and in vitro fertilization outcomes among infertile women.

Objective: To explore the association between snoring and in vitro fertilization (IVF) outcomes in infertile women, focusing on embryological parameters and pregnancy outcomes.

Methods: This study represents a secondary analysis of the PKU-ERC study (NCT05373290). We included a cohort of 632 infertile women, aged 24-45 years, undergoing their first IVF treatment from the Reproductive Center of Peking University People's Hospital between January 2018 and November 2021.

Food supply toxicants and additives alter the gut microbiota and risk of metabolic disease.

Metabolic disease is rising along with both global industrialization and the use of new commercial, agricultural, and industrial chemicals and food additives. Exposure to these compounds may contribute to aspects of metabolic diseases such as obesity, diabetes, and fatty liver disease. Ingesting compounds in the food supply is a key route of human exposure, resulting in the interaction between toxicants or additives and the intestinal microbiota.

Revolutionizing public health through digital health technology.

The aging population and increasing chronic diseases strain public health systems. Advancements in digital health promise to tackle these challenges and enhance public health outcomes. Digital health integrates digital health technology (DHT) across healthcare, including smart consumer devices.

Targeting Glutamine Metabolic Reprogramming in Pancreatic Cancer: Current Insights and Future Directions.

Pancreatic Cancer (PC) is a devastating malignancy with a poor prognosis and in-creasing morbidity. Current treatment strategies have limited efficacy in improving patient survival. Metabolic reprogramming is a hallmark of cancer and plays a key role in the pro-gression and maintenance of PC.

Regulation of TADF by Internal and External Heavy Atom Effect in D-A MOF for Heterocrystal based Temperature-Compensated Photonic Device.

The application of temperature-compensated photonic device is hampered by poor accuracy and overly simplistic functions of propagation in photonic integrated circuits (PICs) field. Herein, we report a new library of donor-acceptor metal-organic framework (D-A MOF) with thermally activated delayed fluorescence (TADF) and the fabricating of temperature-compensated photonic device by virtue of the unique temperature response character of TADF emitters. Highly tunable through-space charge transfer (TSCT) of TADF was realized within the D-A MOFs through a novel strategy that synergistically combines the internal heavy atom effect (HAE) with an external HAE, induced by the incorporation of heavy atoms into different components, achieving the regulable photophysical indicators including adjustable PL wavelength (534 to 592 nm) and surging quantum yield (5.

Immunomodulatory Effects of SPHK1 and Its Interaction with TFAP2A in Yellow Drum ().

Sphingosine kinases (SPHKs) are essential enzymes that catalyze the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), which plays pivotal roles in inflammation and immune regulation. In this study, genome-wide association analysis (GWAS) identified the gene as closely associated with the resistance of yellow drum () to . Structural prediction showed that YDSPHK1 contains a typical diacylglycerol kinase catalytic (DAGKc) domain (154-291 aa).

Genome Insights and Identification of Sex Determination Region and Sex Markers in .

Background: , a member of the Sciaenidae family, is widely distributed across the sea areas near China, Japan, Australia, and South Africa. The aim of this study is to provide a high-quality genome with new technology and to understand the sex determination mechanism of this species.

Methods: We generated a high-quality chromosome-level genome for using PacBio HiFi and Hi-C sequencing technologies.

Donor-Acceptor Functionalized Water-Soluble Metal-Organic Cages Showing an Excellent Synergistic Photothermal-Chemotherapy Effect.

Water-soluble metal-organic cages (WSMOCs) show high potential as antitumor agents, while the targeted functionalization of WSMOCs toward enhanced antitumor performances is a challenging task. Herein, WSMOCs were functionalized with donor-acceptor (D-A) systems for synergistic photothermal-chemotherapy. Octahedral [ML] cages based on a 2,4,6-tri(2-pyridine-4-yl)-1,3,5-triazine (TPT) acceptor and M(bpy) (M = Pd for , Pt for ) nodes were functionalized with tetrathiafulvalene (TTF) to form and .