Nanofibrous Hydrogel with Highly Salt-Resistant Radial/Vertical-Combined Structure for Efficient Solar Interfacial Evaporation.

Hydrogel-based solar interfacial evaporators, featuring various channels such as random, unidirectional, and radial array, are considered effective for seawater desalination owing to their porous structure, lower evaporation enthalpy, and controllable water transport capacity. However, each individual array structure has its own strengths and limitations, influencing water transportation, thermal management, and salt rejection. By combining the benefits of each array configuration into a single evaporator, the evaporation performance can be maximized.

PD-1 promotes tumor evasion via deregulating CD8 T cell function.

Background: The programmed cell death 1 (PD-1) is an immune checkpoint that mediates immune evasion of tumors. Alternative splicing (AS) such as intron retention (IR) plays a crucial role in the immune-related gene processing and its function. However, it is not clear whether encoding PD-1 exists as an IR splicing isoform and what underlying function of such isoform plays in tumor evasion.

Serum Angiopoietin-Like Protein 4 as a Biomarker for Acute Ischemic Stroke Severity and Dynamic Changes.

Background: Angiopoietin-like protein 4 (ANGPTL4) is critical for vascular integrity and reducing inflammation in ischemic and hypoxic brain injuries. However, limited studies have evaluated ANGPTL4's role in acute ischemic stroke (AIS) assessment, and its expression patterns across AIS phases remain unclear.

Methods: The severity of AIS at admission was assessed using the National Institutes of Health Stroke Scale (NIHSS).

Methylprednisolone as Adjunct to Thrombectomy for Acute Intracranial Internal Carotid Artery Occlusion Stroke: Post Hoc Secondary Analysis of the MARVEL Randomized Clinical Trial.

Importance: Patients with acute ischemic stroke (AIS) due to intracranial internal carotid artery (ICA) occlusion often have poor functional outcomes despite undergoing endovascular thrombectomy (EVT).

Objective: To investigate the effectiveness and safety associated with intravenous methylprednisolone as adjunctive treatment to EVT for patients with AIS due to intracranial ICA occlusion.

Design, Setting, And Participants: This was a post hoc analysis of the MARVEL randomized, double-blind, placebo-controlled clinical trial conducted from February 9, 2022, to June 30, 2023, at 82 stroke centers across China with a 3-month follow-up.

Low-background CRISPR/Cas12a sensing system with circular CRISPR RNA for amplified fluorescent detection of antibody in human serum.

Regular monitoring of serum antibody levels is crucial for preventing interference with therapeutic effectiveness and reducing the risk of toxicity. To address this, a CRISPR/Cas12a sensing system with circular CRISPR RNAs (crRNAs) is described for highly sensitive detection of anti-digoxin (Anti-Dig) antibodies in human serum. In this work, the topology structure of crRNAs effectively suppresses the function of linear crRNAs (crRNAs), making them unable to regulate the cis-/trans-cleavage activity of the Cas12a system.

Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC.

Astrocytes, the most prevalent type of glial cells, have been found to play a crucial part in numerous physiological functions. By offering metabolic and structural support, astrocytes are vital for the proper functioning of the brain and regulating information processing and synaptic transmission. Astrocytes located in the medial prefrontal cortex (mPFC) are highly responsive to environmental changes and have been associated with the development of brain disorders.

Nicotine's impact on platelet function: insights into hemostasis mechanisms.

Introduction: Traditional Miao and Dai Chinese medicines have used nicotine-rich leaf tobacco to treat traumatic injuries by promoting hemostasis. While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear.

Methods And Results: This study aimed to thoroughly investigate nicotine's effects on human platelets and its pharmacological mechanisms, using thromboelastography to assess nicotine's impact on platelet function during coagulation.

Effect of resonance acoustic mixing treatment on the gelation properties of pea protein isolate and the gel in vitro digestibility.

This study aimed to investigate the effect of different durations (0, 5, 10, 15, 20, and 30 min) of resonance acoustic mixing (RAM) treatment on the gel properties and digestibility of pea protein isolate (PPI). Results indicated that RAM treatment enhanced the water holding capacity (WHC) of PPI gels, with the highest WHC of 94.79 % achieved after RAM treatment for 20 min.

Tumor-derived extracellular vesicle PD-1 promotes tumor immune evasion via disruption of peripheral T cell homeostasis.

The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) axis mediates immune evasion of tumor, and targeting this axis has achieved some clinical benefits. The regulation of PD-1 expression in immune cells has been well studied. However, whether any other potential source of immune cell-expressed PD-1 exists remains unknown.

Untangling the impacts of bacterial community on carbon dioxide and nitrous oxide across a drinking water reservoir.

Reservoirs represent a critical component of greenhouse gas (GHG) emissions, yet the intricacies of how biotic and abiotic factors influence GHG dynamics within reservoirs remain largely unexplored. Herein, we investigated the spatiotemporal patterns of CO and NO emissions and the underlying factors in the Danjiangkou Reservoir, Asia's largest artificial freshwater reservoir. We found that this reservoir was a significant source of GHGs to the atmosphere, with peak CO emissions observed in autumn (1544.

Preparation and characterization of a rat uterine decellularized scaffold.

Background: Infertility is a special reproductive health defect. For women, congenital uterine malformations, extensive adhesions in the uterine cavity, and hysterectomy are associated with infertility. Uterine transplantation is technically feasible, but its clinical application and development are limited by donor shortages and immune rejection.

P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways.

Ethnopharmacological Relevance: Cryptotanshinone serves as the principal bioactive constituent of Salvia miltiorrhiza Bunge, possesses a wide range of pharmacological activities. Salvia miltiorrhiza Bunge, a long-standing therapeutic agent in traditional Chinese medicine (TCM) practice, is renowned for its efficacy in enhancing blood circulation and alleviating blood stasis and infarction, thereby treating cardiovascular and cerebrovascular diseases.

Aim Of The Study: Platelet activation, when excessive or aberrant, poses a significant risk, catalyzing the onset of various thrombotic disorders.

ABCA1 promote tumor environment heterogeneity via epithelial mesenchymal transition in Huh7 and HepG2 liver cancer cell.

In this study, we delve into the intrinsic mechanisms of cell communication in hepatocellular carcinoma (HCC). Initially, employing single-cell sequencing, we analyze multiple malignant cell subpopulations and cancer-associated fibroblast (CAF) subpopulations, revealing their interplay through receptor-ligand interactions, with a particular focus on SPP1. Subsequently, employing unsupervised clustering analysis, we delineate two clusters, C1 and C2, and compare their infiltration characteristics using various tools and metrics, uncovering heightened cytotoxicity and overall invasion abundance in C1.

Comprehensive Optimization of Packing Parameters for Hydraulic-Packed Capillary Columns.

Rationale: The performance of the capillary column directly impacts the separation efficiency of complex sample in liquid chromatography-mass spectrometry-based proteomics studies. The hydraulic packing system offers an effective solution by reducing packing time and expediting the preparation process of column preparation. However, its operational complexity and strict parameter regulation requirements hinder efficient application.

Trajectory Tracking Control for Robotic Manipulator Based on Soft Actor-Critic and Generative Adversarial Imitation Learning.

In this paper, a deep reinforcement learning (DRL) approach based on generative adversarial imitation learning (GAIL) and long short-term memory (LSTM) is proposed to resolve tracking control problems for robotic manipulators with saturation constraints and random disturbances, without learning the dynamic and kinematic model of the manipulator. Specifically, it limits the torque and joint angle to a certain range. Firstly, in order to cope with the instability problem during training and obtain a stability policy, soft actor-critic (SAC) and LSTM are combined.

JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain.

Midbrain dopamine (mDA) neurons participate in a wide range of brain functions through an intricate regulation of DA biosynthesis. The epigenetic factors and mechanisms in this process are not well understood. Here we report that histone demethylase JMJD3 is a critical regulator for DA biosynthesis in adult mouse mDA neurons.

Three-in-one strategy via anchored MoSe for construct stable conversion-type Na-Se batteries: Chemisorption, catalytic conversion and stress dispersion.

Conversion-type selenium cathodes are considered a highly promising alternative to sulfur cathodes due to their high conductivity and similar theoretical capacity. However, stress-diffusion and shuttle effects during the conversion process remain significant challenges that urgently need to be addressed. Herein, a composite matrix of MoSe anchored on the surface of N-doped hollow mesoporous carbon nanospheres (NHMCNS) was designed as a Se host to construct Se/C cathodes (Se/MoSe@NHMCNS).

Interferon Gamma Receptor 2 Collaborates With Circular RNA/MicroRNA to Modulate Programmed Cell Death-Ligand 1 Levels in Nasopharyngeal Carcinoma.

Background: The effectiveness of immune checkpoint therapy highlights the need to understand abnormal programmed cell death protein-1 (PD-1) expression in nasopharyngeal carcinoma (NPC), especially when treatments fail, or resistance develops. Interferon gamma (IFN-γ) signaling is crucial for regulating programmed cell death-ligand 1 (PD-L1) expression. Our study focuses on interferon gamma receptor 2 (IFNGR2), an essential part of the IFN-γ pathway, and its impact on malignant traits in NPC.

Case report of kabuki syndrome in a newborn caused by KMT2D gene mutation.

Background: Kabuki syndrome is a genetic syndrome that affects multiple organs and systems. Gene mutations are the main cause of KS. Mutations in the KMT2D and KDM6A genes have been reported as two relatively clear pathogenic pathways.

Temperature cues are integrated in a flexible circadian neuropeptidergic feedback circuit to remodel sleep-wake patterns in flies.

Organisms detect temperature signals through peripheral neurons, which relay them to central circadian networks to drive adaptive behaviors. Despite recent advances in Drosophila research, how circadian circuits integrate temperature cues with circadian signals to regulate sleep/wake patterns remains unclear. In this study, we used the FlyWire brain electron microscopy connectome to map neuronal connections, identifying lateral posterior neurons LPNs as key nodes for integrating temperature information into the circadian network.

Animal experimental study of 3D-printed titanium implants based on magnesium-zinc ion surface modification to promote oral soft-tissue closure.

Objective: The study aimed to investigate whether 3D-printed titanium implants modified with magnesium and zinc ion surfaces can promote oral soft-tissue closure.

Method: New Zealand Great White rabbits were selected as experimental animals, and the left and right side mandibular teeth of each animal were randomly divided into an experimental group and control group, each with 18 cases, and the bilateral first premolar teeth were extracted after general anesthesia, and implants were implanted into the magnesium/zinc ionized surface-treated and the surface-untreated groups, respectively.

Results: Under naked-eye observation, the combination of implant material and surrounding soft tissue in the experimental group was significantly better than that in the control group; fluorescence staining showed that the fluorescence density value of the experimental group was significantly higher than that of the control group (p < 0.

Scale-up construction of stable multifunctional hydrogel interfaces for large-scale purification of complex oil-water emulsions and oil recovery.

Inspired by the multi-level structure of grass clumps in nature, a novel filter with plexiform-structured hydrogel interface was constructed using sepiolite-derived silica nanofiber (SiNF) as the supporter and crosslinked polyvinyl alcohol (cl-PVA) hydrogel as the coating. Experimental test, DFT and MD calculations have confirmed that the addition of SiNF can not only enhance oil-water separation efficiency, but also improve the stability of hydrogel coating. The hydrogel interface with excellent stability and superhydrophilic/underwater superoleophobicity can be manufactured on a large copper mesh (1 m × 1.

Selenium-containing metallodrug overcomes cervical cancer radioresistance through physical-chemical dual sensitization.

Radiotherapy is an important treatment for cervical cancer, but the efficacy of radiotherapy is often reduced in clinical practice owing to high frequency and high dose radiation leading to radiotherapy resistance. The development of efficient and low-toxicity radiotherapy sensitizers to reduce radiation dose is an effective strategy. Therefore, based on the existing radiotherapy sensitizers responding to radiophysical sensitization radiotherapy, we propose to design radiotherapy sensitizers with enzyme-mimicking and dual physical-chemical sensitization properties.

Retraction: vitexin attenuates epithelial ovarian cancer cell viability and motility and carcinogenesis via p38 and ERK1/2 pathways related VEGFA.

[This retracts the article DOI: 10.21037/atm-20-5586.].