Endovascular Strategies and Outcomes for Aberrant Splenic Artery Aneurysms.

Objectives: Aberrant splenic artery aneurysms (ASAAs) located at the splenomesenteric trunk (SMT) and the celiacomesenteric trunk have a close anatomical relationship with the superior mesenteric artery (SMA). The aim of this study was to review our institutional experience of endovascular treatment for ASAAs and evaluate the long-term outcomes.

Methods: A retrospective review of patients with ASAAs who underwent endovascular treatment between December 2006 and December 2022 was performed.

mEnrich-seq: methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome.

Metagenomics has enabled the comprehensive study of microbiomes. However, many applications would benefit from a method that sequences specific bacterial taxa of interest, but not most background taxa. We developed mEnrich-seq (in which 'm' stands for methylation and seq for sequencing) for enriching taxa of interest from metagenomic DNA before sequencing.

Nano-carrier DMSN for effective multi-antigen vaccination against SARS-CoV-2.

The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has had a profound impact on the global health and economy. While mass vaccination for herd immunity is effective, emerging SARS-CoV-2 variants can evade spike protein-based COVID-19 vaccines. In this study, we develop a new immunization strategy by utilizing a nanocarrier, dendritic mesoporous silica nanoparticle (DMSN), to deliver the receptor-binding domain (RBD) and conserved T-cell epitope peptides (DMSN-P-R), aiming to activate both humoral and cellular immune responses in the host.

Mechanism of sulfite enhanced As(III) oxidation in the As(III)-Fe minerals under ambient conditions.

Iron (Fe) minerals are known to be effective adsorbents for arsenic (As). However, the effects of sulfur species formed from the reductive dissolution of Fe minerals on the transformation of As(III) during the redox fluctuations processes under ambient conditions were poorly understood. Herein, we synthesized the As(III)-Fe minerals using sodium arsenite and ferric nitrate to investigate the effects of sulfur species on As(III) transformation in the As(III)-Fe minerals.

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway.

Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear.

Novel poly (-methacryloyl-L-alanine acid) grafted chitosan microspheres based solid-phase extraction coupled with ICP-MS for simultaneous detection of trace metal elements in food.

Poly (-methacryloyl-L-alanine acid) grafted tartaric acid-crosslinked chitosan microspheres (PNMA-TACS) were successfully synthesized and employed as a novel adsorbent for the separation and enrichment of metal ions in the food system. PNMA-TACS microspheres-based solid phase extraction (SPE) was coupled with ICP-MS for accurate quantification of trace V(V), Cr(III), As(III), Pb(II), Cd(II) and Cu(II). The obtained PNMA-TACS microspheres were characterized, and parameters influencing the method were optimized.

Pathologic complete response prediction in breast cancer lesion segmentation and neoadjuvant therapy.

Objectives: Predicting whether axillary lymph nodes could achieve pathologic Complete Response (pCR) after breast cancer patients receive neoadjuvant chemotherapy helps make a quick follow-up treatment plan. This paper presents a novel method to achieve this prediction with the most effective medical imaging method, Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI).

Methods: In order to get an accurate prediction, we first proposed a two-step lesion segmentation method to extract the breast cancer lesion region from DCE-MRI images.

Preparation and characterization of cellulose nanofibril/chitosan aerogels with high-adsorbability and sensitive indication for indoor free formaldehyde.

The toxic volatile organic compounds (VOCs), especially formaldehyde (FA), released from decoration materials pose a great threat to human health. In this study, formaldehyde adsorption performance of the specially formulated nanocellulose/chitosan aerogel (CNFCA) was investigated in simulated atmosphere. The physicochemical property of the composite aerogel was characterized, which had a large specific surface area (153.

Resonant Magnetoelectric Coupling of Fe-Si-B/Pb(Zr,Ti)O Laminated Composites with Surface Crystalline Layers.

The resonant magnetoelectric (ME) effect of FeSiB/Pb(Zr,Ti)O (FeSiB/PZT) composites with a surface-modified FeSiB amorphous alloy has been studied. The surface-modified FeSiB can improve the ME coefficient at the resonant frequency by optimizing the magnetomechancial power conversion efficiency. The maximum ME coefficient of the surface-modified ribbons combined with soft PZT (PZT5) is two-thirds larger than that of the composites with fully amorphous ribbons.

Efficient Fast Fractionation of Biomass Using a Diol-Based Deep Eutectic Solvent for Facilitating Enzymatic Hydrolysis and Obtaining High-Quality Lignin.

Current DES pretreatment is often performed under relatively severe conditions with high temperature, long time, and high DES usage. This work studied a short-time diol DES (deep eutectic solvent) pretreatment under mild conditions to fractionate the bamboo, facilitate enzymatic hydrolysis, and obtain high-quality lignin. At an optimized condition of 130 °C for only 10 min, lignin and xylan removal reached 61.

Large-n quasi-phase-pure two-dimensional halide perovskite: A toolbox from materials to devices.

Despite their excellent environmental stability, low defect density, and high carrier mobility, large-n quasi-two-dimensional halide perovskites (quasi-2DHPs) feature a limited application scope because of the formation of self-assembled multiple quantum wells (QWs) due to the similar thermal stabilities of large-n phases. However, large-n quasi-phase-pure 2DHPs (quasi-PP-2DHPs) can solve this problem perfectly. This review discusses the structures, formation mechanisms, and photoelectronic and physical properties of quasi-PP-2DHPs, summarises the corresponding single crystals, thin films, and heterojunction preparation methods, and presents the related advances.

RNase H-Driven crRNA Switch Circuits for Rapid and Sensitive Detection of Various Analytical Targets.

The clustered regularly interspaced short palindromic repeats (CRISPR/Cas12a) system has exhibited great promise in the rapid and sensitive molecular diagnostics for its trans-cleavage property. However, most CRISPR/Cas system-based detection methods are designed for nucleic acids and require target preamplification to improve sensitivity and detection limits. Here, we propose a generic crRNA switch circuit-regulated CRISPR/Cas sensor for the sensitive detection of various targets.

Interactive Multi-Stage Robotic Positioner for Intra-Operative MRI-Guided Stereotactic Neurosurgery.

Magnetic resonance imaging (MRI) demonstrates clear advantages over other imaging modalities in neurosurgery with its ability to delineate critical neurovascular structures and cancerous tissue in high-resolution 3D anatomical roadmaps. However, its application has been limited to interventions performed based on static pre/post-operative imaging, where errors accrue from stereotactic frame setup, image registration, and brain shift. To leverage the powerful intra-operative functions of MRI, e.

Aqueous Rechargeable Zn-Iodine Batteries: Issues, Strategies and Perspectives.

The static aqueous rechargeable Zn-Iodine batteries (ARZiBs) have been studied extensively because of their low-cost, high-safety, moderate voltage output, and other unique merits. Nonetheless, the poor electrical conductivity and thermodynamic instability of the iodine cathode, the complicated conversion mechanism, and the severe interfacial reactions at the Zn anode side induce their low operability and unsatisfactory cycling stability. This review first clarifies the typical configuration of ARZiBs with a focus on the energy storage mechanism and uncovers the issues of the ARZiBs from a fundamental point of view.

Study on the effect of different aldehyde modifiers on the fume suppression effect, mechanism and road performance of SBS modified asphalt.

In order to curb asphalt fume emissions during the heating process of styrene-butadiene-styrene (SBS) asphalt, three aldehyde modifiers [vanillin (X), citral (N) and amyl cinnamaldehyde (J)] were blended into SBS-modified asphalt to prepare aldehyde-modified asphalt in this paper. By collecting solid particles and volatile organic compounds (VOCs) in asphalt fumes to conduct relevant experiments, we have analyzed the fume suppression effect and suppression mechanism of aldehyde modified asphalt, and finally examined the road performance of aldehyde modifiers with the best fume suppression effect. It was found that the average VOCs concentration of aldehyde modified asphalt was reduced by about 78 % after 30 min.

The Diurnal Transcriptome Reveals the Reprogramming of Lung Adenocarcinoma Cells Under a Time-Restricted Feeding-Mimicking Regimen.

Background: The processes of tumor growth and circadian rhythm are intimately intertwined; thus, rewiring circadian metabolism by time-restricted feeding (TRF) may contribute to delaying carcinogenesis. However, research on the effect of a TRF cellular regimen on cancer is lacking.

Objective: Investigate the circadian signatures of TRF in lung cancer in vitro.

DMMG: Dual Min-Max Games for Self-Supervised Skeleton-Based Action Recognition.

In this work, we propose a new Dual Min-Max Games (DMMG) based self-supervised skeleton action recognition method by augmenting unlabeled data in a contrastive learning framework. Our DMMG consists of a viewpoint variation min-max game and an edge perturbation min-max game. These two min-max games adopt an adversarial paradigm to perform data augmentation on the skeleton sequences and graph-structured body joints, respectively.

Monitoring longitudinal antimicrobial resistance trends of Staphylococcus aureus strains worldwide over the past 100 years to decipher its evolution and transmission.

Staphylococcus aureus inhabits diverse habitats including food waste and wastewater treatment plants. Cases of S. aureus-induced infection are commonly reported worldwide.

Charge Carriers Localization Effect Revealed through Terahertz Spectroscopy of MXene: TiCT.

The transport properties of charge carriers in MXene, a promising material, have been studied using terahertz time-domain spectroscopy (THz-TDS) to examine its potential applications in optical and electronic devices. However, previous studies have been limited by narrow frequency ranges, which have hindered the understanding of the intrinsic mechanisms of carrier transport in MXenes. To address this issue, ultrabroadband THz-TDS with frequencies of up to 15 THz to investigate the complex photoconductances of MXene (TiCT) films with different thicknesses are employed.

CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.

Osteoarthritis (OA) is the most prevalent age-related and degenerative joint disease with limited treatment options. Previous studies have identified the therapeutic effects of mesenchymal stem cells (MSCs) therapy. Nevertheless, chronic inflammation impedes MSCs therapeutic effect.

Pyroptosis: shedding light on the mechanisms and links with cancers.

Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents, such as Interleukin (IL) 8, IL-1β, ATP, IL-1α, and high mobility group box 1 (HMGB1). Our understanding of pyroptosis has increased over time with an increase in research on the subject: gasdermin-mediated lytic PCD usually, but not always, requires cleavage by caspases. Moreover, new evidence suggests that pyroptosis induction in tumor cells results in a strong inflammatory response and significant cancer regression, which has stimulated great interest among scientists for its potential application in clinical cancer therapy.

Ultrasmall calcium-enriched Prussian blue nanozymes promote chronic wound healing by remodeling the wound microenvironment.

Chronic wound healing remains challenging due to the oxidative microenvironment. Prussian blue (PB) nanoparticles exhibiting multiple antioxidant enzyme-like activities have attracted widespread attention, while their antioxidant efficacy remains unsatisfied. Herein, ultrasmall calcium-enriched Prussian blue nanoparticles (CaPB NPs) are simply constructed with high yields for the wound repair application.

Horizontal gene transfer in activated sludge enhances microbial antimicrobial resistance and virulence.

Activated sludge (AS) plays a vital role in removing organic pollutants and nutrients from wastewater. However, the risks posed by horizontal gene transfer (HGT) between bacteria in AS are still unclear. Here, a total of 478 high-quality non-redundant metagenome-assembled genomes (MAGs) were obtained.

An Off-Pump Repair Technique for Postinfarction Apical Left Ventricular Aneurysm.

Purpose: The conventional surgical treatment for postinfarction left ventricular aneurysm (LVA) is open-heart repair with cardiopulmonary bypass. However, the risk of the open-heart surgery under cardiopulmonary bypass may result in an unacceptable risk for many patients with multiple comorbidities. Here, we reported a new off-pump repair technique for postinfarction apical LVA.