ATG 4B Serves a Crucial Role in RCE-4-Induced Inhibition of the Bcl-2-Beclin 1 Complex in Cervical Cancer Ca Ski Cells.

RCE-4, a steroidal saponin isolated from , has been studied previously and has exhibited promising anti-cervical cancer properties by inducing programmed cell death (PCD) of Ca Ski cells. Considering the cancer cells developed various pathways to evade chemotherapy-induced PCD, there is, therefore, an urgent need to further explore the potential mechanisms underlying its actions. The present study focused on targeting the Bcl-2-Beclin 1 complex, which is known as the key regulator of PCD, to deeply elucidate the molecular mechanism of RCE-4 against cervical cancer.

[Clinical Characteristics and Prognosis of Multiple Myeloma Patients with Different Results of Blood Separation].

Objective: To investigate clinical characteristics of multiple myeloma（MM） patients with two different results of blood separation in vacum blood collection tubes containing separator gels after centrifugation, and evaluate the prognostic value of these two results.

Methods: The clinical data of 168 patients with newly diagnosed MM treated in our hospital from March 2009 to December 2017 were retrospectively analyzed. The blood samples were divided into control group（the order from top to bottom is serum,separator gel and red blood cell） and abnormal group（the order from top to bottom is serum, red blood cell, separator gel and red blood cell） according to the results of blood separation in vacum blood collection tubes containing separator gels after centrifugation.

Photoreactivation of (6-4) photolyase in Dunaliella salina.

Dunaliella salina is a unicellular green alga and possesses two types of photolyase: Class II cyclobutane pyrimidine dimers (CPD) photolyase and (6-4) photolyase. The gene of D. salina (6-4) photolyase is the first one found in unicellular organisms.