Publications by authors named "Fang Chan"

Future information technologies for low-dissipation quantum computation, high-speed storage, and on-chip communication applications require the development of atomically thin, ultracompact, and ultrafast spintronic devices in which information is encoded, stored, and processed using electron spin. Exploring low-dimensional magnetic materials, designing novel heterostructures, and generating and controlling ultrafast electron spin in 2D magnetism at room temperature, preferably in the unprecedented terahertz (THz) regime, is in high demand. Using THz emission spectroscopy driven by femtosecond laser pulses, optical THz spin-current bursts at room temperature in the 2D van der Waals ferromagnetic Fe GeTe (FGT) integrated with Bi Te as a topological insulator are successfully realized.

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Canine parvovirus type 2 (CPV-2) is among the most important and highly contagious pathogens that cause enteric or systemic infections in domestic and nondomestic carnivores. However, the spillover of CPV-2 to noncarnivores is rarely mentioned. Taiwanese pangolins () are threatened due to habitat fragmentation and prevalent animal trafficking.

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Aims: To explore the working experiences of Chinese hospital care workers from their own perspectives.

Background: Many countries face an increasing demand for nursing care and an acute shortage of registered nurses. As a result, much of the care work at hospitals is delegated to assistant staff, such as care workers.

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Article Synopsis
  • The study investigates the role of the GSTM1 enzyme, linked to kidney disease, using knockout mice to understand its impact on chronic kidney disease (CKD) and hypertension models.
  • Results showed that knockout mice experienced more oxidative stress and kidney damage, and using a superoxide dismutase mimetic helped improve their condition without affecting blood pressure.
  • In humans, higher intake of cruciferous vegetables correlated with fewer kidney failure events, particularly in individuals carrying the deletion variant of GSTM1, indicating the enzyme's influence on kidney health.
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Intronic variants of the gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of have remained elusive. Rare missense mutations in cause macrothrombocytopenia and are occasionally associated with development of nephropathy.

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Collectrin, encoded by the gene, is a transmembrane glycoprotein with approximately 50% homology with angiotensin converting enzyme 2, but without a catalytic domain. Collectrin is most abundantly expressed in the kidney proximal tubule and collecting duct epithelia, where it has an important role in amino acid transport. Collectrin is also expressed in endothelial cells throughout the vasculature, where it regulates L-arginine uptake.

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Background: Collectrin is an orphan member of the renin-angiotensin system and is a homolog of angiotensin-converting enzyme 2, sharing ≈50% sequence identity. Unlike angiotensin-converting enzyme 2, collectrin lacks any catalytic domain. Collectrin has been shown to function as a chaperone of amino acid transporters.

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