Effect of immune checkpoint inhibitor time-of-day infusion on survival in advanced biliary tract cancer: a propensity score-matched analysis.

Background: Circadian rhythms in the immune system and anti-tumor responses are underexplored in cancer immunotherapy. Despite the success of immune checkpoint inhibitors (ICIs) in treating advanced biliary tract cancers (BTCs), not all patients benefit. This study examined whether the timing of ICI administration affects outcomes in advanced BTC patients.

Effects of antiseizure medication withdrawal during the first trimester of pregnancy on seizure control and offspring outcomes.

Objective: To explore seizure control and offspring outcomes associated with antiseizure medication (ASM) withdrawal during the first trimester of pregnancy.

Methods: Based on a prospective multicenter study in China, pregnancies followed up between 2009 and 2023 at the neurology outpatient clinic of 50 hospitals were included in this study. Information on demographics, epileptic characteristics, treatment during pregnancy, and offspring outcomes was collected.

Analysis of research topics and trends in investigator-initiated research/trials (IIRs/IITs): A topic modeling study.

Background: With the exponential growth of publications in the field of investigator-initiated research/trials (IIRs/IITs), it has become necessary to employ text mining and bibliometric analysis as tools for gaining deeper insights into this area of study. By using these methods, researchers can effectively identify and analyze research topics within the field.

Methods: This study retrieved relevant publications from the Web of Science Core Collection and conducted bioinformatics analysis.

Controlling Isomerization of Photoswitches to Modulate 2D Logic-in-Memory Devices by Organic-Inorganic Interfacial Strategy.

Logic-in-memory devices are a promising and powerful approach to realize data processing and storage driven by electrical bias. Here, an innovative strategy is reported to achieve the multistage photomodulation of 2D logic-in-memory devices, which is realized by controlling the photoisomerization of donor-acceptor Stenhouse adducts (DASAs) on the surface of graphene. Alkyl chains with various carbon spacer lengths (n = 1, 5, 11, and 17) are introduced onto DASAs to optimize the organic-inorganic interfaces: 1) Prolonging the carbon spacers weakens the intermolecular aggregation and promotes isomerization in the solid state.

Dramatically enhanced Seebeck coefficient in GeMnTe-NaBiTe alloys by tuning the Spin's thermodynamic entropy.

The emerging material GeMnTe provides a rare example to study the spin degree of freedom in thermoelectric transport, as it exhibits an anomalous Seebeck coefficient driven by the spin's thermodynamic entropy. This work presents an unconventional strategy to optimize the thermoelectric performance of GeMnTe by manipulating the spin degree of freedom. NaBiTe is alloyed into GeMnTe to disorder the spin orientation under finite temperature, and the obtained Seebeck coefficient is confirmed to be dramatically enhanced by more than 150%.

Achieving High Thermoelectric Performance of n-Type BiTeSe Sintered Materials by Hot-Stacked Deformation.

Bismuth telluride has been the only commercial thermoelectric candidate, but the n-type sintered material lags well behind the p-type one in the value, which severely limits the further development of thermoelectrics. Here, we report a promising technique named hot-stacked deformation to effectively improve the thermoelectric properties of n-type BiTeSe + 0.067 wt % BiCl materials based on zone-melting ingots.

Enhanced Thermoelectric Properties of p-Type BiSbTe/SbTe Composite.

Constructing a nanocomposite to introduce a coherent interface is an effective way to improve the property of thermoelectric material. Here, a series composites of BiSbTe- wt % SbTe ( = 0, 0.3, 0.