Diverse indole-diterpenoids with protein tyrosine phosphatase 1B inhibitory activities from the marine coral-derived fungus Aspergillus sp. ZF-104.

Eight previously undescribed indole-diterpenoids named penerpenes O-V (1-8), together with seven known analogues (9-14), were isolated from the marine soft coral-derived fungus Aspergillus sp. ZF-104. Their structures including the absolute configurations of these compounds were assigned on the basis of spectroscopic data and ECD analysis along with quantum ECD and NMR calculations.

Carotane sesquiterpenoids A-G from the desert endophytic fungus sp. HM 166.

Seven undescribed carotane sesquiterpenoids named fusanoids A-G (1-7), along with one known analog (8) and two known sesterterpenes (9 and 10), were isolated from the fermentation broth of the desert endophytic fungi sp. HM166. The structures of the compounds, including their absolute configurations, were determined by spectroscopic data, single-crystal X-ray diffraction analysis, and ECD calculations.

Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic G10.

Eight new phenethoxy derivatives, trichoasperellins A-H (-), were isolated from the endophytic fungus G10 isolated from the medicinal plant L. The structures of these compounds were elucidated from spectroscopic data, -based configurational analysis, and Mosher's methods. Compounds - and - bear one or two multioxidized C moieties with the same carbon skeleton.

Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus sp. of .

Three new humulane-type sesquiterpenoids, penirolide A (), penirolide B (), and 10-acetyl-phomanoxide (), together with three known compounds aurasperone A (), pughiinin A (), and cyclo(l-Leu-l-Phe) () were isolated from the endophytic fungus sp derived from the leaves of L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds , , , and significantly inhibited glucagon-induced hepatic glucose production, with EC values of 33.

Cytotoxic Indole-Diterpenoids from the Marine-Derived Fungus sp. KFD28.

Four new indole-diterpenoids, named penerpenes K-N (-), along with twelve known ones (-), were isolated from the fermentation broth produced by adding L-tryptophan to the culture medium of the marine-derived fungus sp. KFD28. The structures of the new compounds were elucidated extensively by 1D and 2D NMR, HRESIMS data spectroscopic analyses and ECD calculations.

Triterpenoids and meroterpenoids with α-glucosidase inhibitory activities from the fruiting bodies of Ganoderma australe.

Macrofungi Ganoderma is a valuable medicinal fungus resource for human health and longevity in China. In this study, ten undescribed compounds including seven lostane-type triterpenoids, ganodaustralic acids A ∼ G (1-7), one pair of meroterpenoid enantiomers, (-)-6'-O-ethyllingzhiol (8) and (+)-6'-O-ethyllingzhiol (9), and one polyhydroxylated sterol, 3-O-acetyl-fomentarol C (10), together with eight known compounds (11-18), were isolated from the fruiting bodies of Ganoderma australe. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and electronic circular dichroism (ECD) calculations.

Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus sp. HNMF114.

By feeding tryptophan to the marine-derived fungus sp. HNMF114 from the bivalve mollusk , 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (-), along with 16 known ones (-), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra.

[Study on chemical constituents from fruiting bodies of Ganoderma calidophilum].

Chemical constituents were isolated and purified from fruiting bodies of Ganoderma calidophilum by various column chromatographic techniques, and their chemical structures were identified through combined analysis of physicochemical properties and spectral data. As a result, 11 compounds were isolated and identified as(24E)-lanosta-8,24-dien-3,11-dione-26-al(1), ganoderone A(2), 3-oxo-15α-acetoxy-lanosta-7,9(11), 24-trien-26-oleic acid(3),(23E)-27-nor-lanosta-8,23-diene-3,7,25-trione(4), ganodecanone B(5), ganoderic aldehyde A(6), 11β-hydroxy-lucidadiol(7), 3,4-dihydroxyacetophenone(8), methyl gentiate(9), ganoleucin C(10), ganotheaecolumol H(11). Among them, compound 1 is a new triterpenoid.

Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic Fungus .

Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a -associated fungus , two structurally new polyketides ( and ) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations.

A new picrotoxane-type sesquiterpene from Lindl.

A picrotoxane-type sesquiterpene, dendroterpene E (), together with five benzene derivatives (), were isolated from the stems of Lindl. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compound was a new picrotoxane-type sesquiterpene with a C-9/C-1/O/C-11 oxetane ring, which was first encountered in this type of compounds.

Two new indole-diterpenoids from the marine-derived fungus sp. KFD28.

Two new compounds named epipaxilline () and penerpene J () were isolated from the marine-derived fungus sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis.

Napthrene Compounds from Mycelial Fermentation Products of .

The metabolites of the genus are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi , the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A-B (,) and naphthone C (), as well as 12 known compounds (-). Compounds , , and are dimeric naphthalene compounds.

Biphenyl metabolites from the patchouli endophytic fungus Alternaria sp. PfuH1.

Patchouli is a tropical medicinal and spice crop with high economic value, and the endophytic microorganism is also one of its important components and can provide new active compounds with medicinal use. In the present study, four new biphenyl compounds named 3-O-demethylaltenuisol (1), (-)-dialtenuisol (5) and (+)-dialtenuisol (6), and altertoxin VII (9), as well as six known related compounds, were isolated from the patchouli (Pogostemon cablin) endophytic fungus Alternaria sp. PfuH1.

Asperpenes D and E from the fungus sp. SCS-KFD66 isolated from a bivalve mollusk, .

Two new compounds named asperpenes D () and E () were isolated from the marine-derived fungus sp. SCS-KFD66. Their structures were determined on the basis of spectroscopic methods.

Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus sp. HNMF114.

Seven new quinazoline-containing indole alkaloids (-) named aspertoryadins A-G, along with nine known ones (-), were isolated from the marine-derived fungus sp. HNMF114 from the bivalve mollusk . The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations.

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Pierre ex Lecomte in Laos.

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone were isolated from the agarwood of Pierre ex Lecomte in Laos. The structures of the isolates were elucidated by spectroscopic methods, and their configurations were determined via ROESY correlations, coupling constants analyses, comparisons of chemical shifts and specific rotations with known compounds, and ECD calculation in the case of . Compounds - were evaluated for their cytotoxicity.

Polyketides with quorum sensing inhibitory activity from the marine-derived fungus sp. ZF-79.

Seven compounds were isolated from a marine-derived fungus sp. ZF-79, including three new polyketides (-), named asperochrins D-F, along with four known compounds . Their structures were determined on the basis of spectroscopic methods.

Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus sp. KFD28.

Five new indole-terpenoids named penerpenes E-I (-), along with seven known ones (-), were isolated from the marine-derived fungus sp. KFD28 from a bivalve mollusk, . The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses.

Penerpenes A-D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28.

Four unusual indole-terpenoids, penerpenes A-D (1-4), along with two known ones paxilline (5) and emindole SB (6), were isolated from the marine-derived fungus Penicillium sp. KFD28. The absolute structures of 1-4 were elucidated on the basis of spectroscopic data and ECD spectra analysis along with quantum ECD calculations.

UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from .

Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A-K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from . Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9-11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.

[Study on chemical constituents from fruiting bodies of Ganoderma australe].

Chemical constituents were isolated from the fruiting bodies of Ganoderma australe by various column chromatographic techniques and HPLC method, and their chemical structures were identified through the combined analysis of physicochemical properties and spectral data. Meanwhile, their α-glucosidase inhibitory activity and anti-oxidative ability were evaluated. Seven compounds were isolated from G.

Divergolides T⁻W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete sp. KFD18.

Four new ansamycins, named divergolides T-W (-), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis.

Five new epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones from Chinese agarwood by artificial holing.

Five optically active epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone derivatives (1-5) with four chirality centers in the condensed cyclohexene ring were isolated from artificial holing agarwood originating from Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses.

Three New 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originated from .

Two new 2-(2-phenylethyl)chromone derivatives (⁻), comprising 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and benzylacetone moieties, together with one new 2-(2-phenylethenyl)chromone () were isolated from the ethyl acetate extraction of agarwood originated from Ridl. All structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. All isolated compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxic activity against human myeloid leukemia cell line (K562).