Publications by authors named "Fan-Xuan Kong"

Stem cells and gene therapy have become promising strategies for treating ischemic diseases and regenerating tissue. Hepatocyte growth factor (HGF) is an angiogenic growth factor with multiple functions, including promoting angiogenesis, regulating inflammation, inhibiting fibrosis, and activating tissue regeneration. Numerous preclinical experiments and clinical trials have demonstrated the feasibility and efficacy of HGF gene therapy in the treatment of ischemic diseases and tissue regeneration.

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Objective: To investigate the effect and mechanism of miR-486 on glycometabolism of hematopoietic cells.

Methods: qRT-PCR was applied to detect the expression of miR-486 or Sirt1 on TF-1 cells under hypoxia. Lentivirus was used to mediate the overexpression or inhibition of miR-486 on TF-1 cells and qRT-PCR was used to detect the expressions of Sirt1, glucose transporter 1(Glut1) and glucose transporter 4(Glut4).

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MicroRNAs (miRNAs) regulate the hypoxia-induced erythroid differentiation of hematopoietic cells. In this study, we identified that miR-486 was a rapid response miRNA to hypoxia in erythroleukemia TF-1 cells. Hypoxia exposure increased both intracellular and miR-486 levels of TF-1 cells.

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Synopsis of recent research by authors named "Fan-Xuan Kong"

  • - Fan-Xuan Kong's research primarily focuses on the therapeutic applications of gene therapy and microRNAs in the context of ischemic diseases and hematopoietic cell metabolism, particularly examining the roles of hepatocyte growth factor (HGF) and miR-486.
  • - His study on HGF gene therapy highlights its potential in promoting angiogenesis, regulating inflammation, and facilitating tissue regeneration, supported by preclinical and clinical evidence demonstrating its efficacy for treating ischemic conditions.
  • - Additionally, Kong's investigations into miR-486 reveal its critical role in regulating glycometabolism in hematopoietic cells, specifically through targeting Sirt1, and its involvement in hypoxia-induced erythroid differentiation, suggesting significant implications for understanding cellular responses in stress conditions.