Cesium Amide-Catalyzed Selective Deuteration of Benzylic C-H Bonds with D and Application for Tritiation of Pharmaceuticals.

Hydrogen isotope exchange (HIE) represents one of the most attractive labeling methods to synthesize deuterium- and tritium-labeled compounds. Catalytic HIE methods that enable site-selective C-H bond activation and exchange labeling with gaseous isotopes D and T are of vital importance, in particular for high-specific-activity tritiation of pharmaceuticals. As part of our interest in exploring s-block metals for catalytic transformations, we found CsN(SiMe ) to be an efficient catalyst for selective HIE of benzylic C-H bonds with D gas.

Relationship between mismatch repair protein, , , gene expression and clinicopathological characteristics in elderly colorectal cancer patients.

Background: Colorectal cancer (CRC) is common in elderly patients. Mismatch repair (MMR) protein deletion is one of the causes of CRC. The (), , and genes are important gene targets in CRC treatment and are closely related to the prognosis and survival of patients.

Robot-assisted gallbladder-preserving hepatectomy for treating S5 hepatoblastoma in a child: A case report and review of the literature.

Background: Hepatoblastoma (HB) is the most common hepatic malignant tumour in children, accounting for approximately 50%-60% of primary hepatic malignant tumours in children, mostly in children under 3 years old. In Western countries, the incidence of hepatoblastoma is approximately 1-2/100000. Da Vinci surgical system is fast becoming a key instrument in microinvasive surgery.

Combined small bowel and reduced auxiliary liver transplantation: case report.

Aim: To present a case of combined small bowel and reduced auxiliary liver transplantation.

Methods: A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver function and to protect the intestinal allograft from rejection.