Novel Magnet and Thermoresponsive Chemosensory Electrospinning Fluorescent Nanofibers and Their Sensing Capability for Metal Ions.

Novel multifunctional switchable chemosensors based on fluorescent electrospun (ES) nanofibers with sensitivity toward magnetism, temperature, and mercury ions (Hg) were prepared using blends of poly(N-isopropylacrylamide)-co-(N-methylolacrylamide)-co-(Acrylic acid), the fluorescent probe 1-benzoyl-3-[2-(2-allyl-1,3-dioxo-2,3-dihydro-1Hbenzo[de]isoquinolin-6-ylamino)-ethyl]-thiourea (BNPTU), and magnetite nanoparticles (NPs), and a single-capillary spinneret. The moieties of N-isopropylacrylamide, N-methylolacrylamide, acrylic acid, BNPTU, and Iron oxide (Fe₃O₄) NPs were designed to provide thermoresponsiveness, chemical cross-linking, Fe₃O₄ NPs dispersion, Hg sensing, and magnetism, respectively. The prepared nanofibers exhibited ultrasensitivity to Hg (as low as 10 M) because of an 80-nm blueshift of the emission maximum (from green to blue) and 1.

Association Study of Single-Nucleotide Polymorphisms of STAT2/STAT3/IFN-γ Genes in Cervical Cancer in Southern Chinese Han Women.

Objective: Interferon-γ (IFN-γ) and signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection. Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV), and previous studies suggested that dysregulation of the signal pathway involved in IFN-γ and STATs is associated. Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-γ with cervical cancer susceptibility in Chinese Han women in Hunan province.