Impact of Replacing Sedentary Behavior with Physical Activity and Sleep on Stroke Risk: A Prospective Cohort Study.

Objective: Our research explores how leisure-time sedentary behavior (SB) correlates with stroke risk. Additionally, we utilize the isotemporal substitution model (ISM) to examine how replacing brief durations of leisure-time SB with light physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep might influence the risk of stroke.

Methods: This investigation tracked 478,198 participants from the UK Biobank.