Publications by authors named "Fan-Chun Bin"
Perspective on Water-Soluble Two-Photon Initiator for Two-Photon Polymerization.
ACS Appl Mater Interfaces
October 2024
Two-photon polymerization (TPP) as an unparalleled technology empowers the rapid prototyping of customized three-dimensional (3D) micro/nanostructures, garnering noticeable interest in tissue engineering, drug delivery, and regenerative medicine. These applications have a high requirement on the biocompatibility and integrity of 3D structures. Therefore, it is important to develop two-photon initiator with good water-solubility, initiation efficiency, and biocompatibility.
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- - Hydrogels with embedded chondrocytes show promise for regenerating hyaline cartilage, but chondrocytes often lose their specialized functions in lab settings, risking the quality of the cartilage produced.
- - Researchers have developed chondrocyte pericellular matrix (PCM)-like scaffolds using a sophisticated laser technique, which helps maintain the health and round shape of chondrocytes while promoting the production of essential extracellular matrix.
- - These scaffolds, varying in stiffness and designed with specific geometric features, effectively support cartilage formation and enhance our understanding of how physical properties influence cell behavior, paving the way for advancements in tissue engineering.
Article Synopsis
- Repairing damaged articular cartilage is tough because it doesn't regenerate well, but using hydrogels like BSA-GMA can help mimic the extracellular matrix and support cartilage repair.
- A study found that specially designed scaffold shapes (like round and hexagonal) can keep chondrocytes healthy and prevent them from losing their characteristics during culture.
- This research suggests that BSA-GMA scaffolds not only support cell growth but also improve prospects for chondrocyte transplants in treating cartilage diseases.
Although the development of three-dimensional (3D) printing technology is growing rapidly in the biomedical field, it remains a challenge to achieve arbitrary 3D structures with high resolution and high efficiency. Protein hydrogels fabricated by two- photon polymerization (TPP) have excellent mechanical properties, high precision, and 3D architecture. However, a large number of the amino acid group in bovine serum albumin (BSA) would be consumed when the protein-based hydrogels use dyes of free radical type II photoinitiators.
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- Three-dimensional (3D) bioinspired hydrogels are significant in tissue engineering due to their strong compatibility with biological systems.
- The research investigates the high-precision two-photon polymerization (TPP) of these hydrogels using a specific hyaluronic acid-based precursor and particular cross-linking agents.
- Key results include achieving a fine line width of 22 nm, an average Young's modulus of 94 kPa, and confirmed cell biocompatibility, highlighting the potential for advanced 3D hydrogel scaffolds in medical applications.