Publications by authors named "Fan Yuhua"

Ambient electrochemical NO reduction presents a dual solution for sustainable NO reduction and NH synthesis. However, their complex kinetics and energy demands necessitate high-performance electrocatalysts to ensure effective and selective process outcomes. Herein, we report that a two-dimensional Cu-based metal-organic framework (MOF), {[Cu(HL)]·HO} , (, HL = 5-(2'-carboxylphenoxy)isophthalic acid) acts as a stable electrocatalyst with high efficiency for NO-to-NH conversion.

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  • Progressive multifocal leukoencephalopathy (PML) is a severe brain disease caused by the John Cunningham Virus (JCV), with no widely accepted antiviral treatment available.
  • A case study reports a patient with previous immunosuppressive therapy for dermatomyositis, who was diagnosed with PML and treated with a combination of low-dose immunoglobulin and mirtazapine, leading to significant clinical improvement and a decrease in JCV levels to zero after four months.
  • This findings suggest that this combined treatment approach may effectively regulate the immune response and control the progression of PML, presenting a potential new therapy option.
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Purpose: More accurate prediction of phenotype traits can increase the success of genomic selection in both plant and animal breeding studies and provide more reliable disease risk prediction in humans. Traditional approaches typically use regression models based on linear assumptions between the genetic markers and the traits of interest. Non-linear models have been considered as an alternative tool for modeling genomic interactions (i.

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  • Metal-organic frameworks (MOFs) are being prioritized as electrocatalysts due to their structure's influence on catalytic efficiency and stability.
  • Various MOFs were created using different ligands and a mixed-ligand strategy, with one specific MOF showcasing superior performance in oxygen evolution reactions (OER), indicated by its low overpotential and stable activity.
  • Density functional theory (DFT) calculations confirm that the critical step in the OER process occurs from O* to OOH*, highlighting how MOF structure impacts its electrocatalytic effectiveness.
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  • Synthetic mid-urethral sling surgery is a common treatment for stress urinary incontinence (SUI), and an alternative using an autologous fascial sling may reduce complications.
  • A study of 33 female patients (ages 39-79) evaluated a new fixation method for the autologous transobturator fascial (TOF) sling, showing significant improvements in urinary distress and symptom scores after surgery.
  • The results indicated that while most patients experienced notable symptom relief, a few complications occurred, including voiding dysfunction and mild discomfort, suggesting that the modified procedure is beneficial but not without risks.
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MOF-based materials, as bifunctional catalysts for electrocatalytic water splitting, play an important role in the application and development of clean fuel hydrogen energy. This study presents a series of novel 3D Co-based MOFs with layered networks, including [Co(4,4'-bipy)(aip)(CHOH)·HO] (), [Co(1,3'-bit)(aip)(CHOH)·HO] (), [Co(4,4'-bipb)(aip)] (), and [Co(4,4'-bipe)(aip)·1.5HO] ().

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Cold hypersensitivity in the hands and feet (CHHF) is a protective or predisposing factor for many diseases; however, the relationship between CHHF and erectile dysfunction (ED) remains unclear. We aimed to investigate associations between CHHF and ED among young men of Southeast Asian origin. In this cross-sectional study, sexually active Taiwanese men aged 20-40 years were enrolled via an online questionnaire comprising general demographic information, comorbidities, subjective thermal sensations of their hands and feet in the past 6 months, and their erectile function using the International Index of Erectile Function-5 (IIEF-5).

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Cerebral small vessel disease (SVD) may be associated with an increased risk of depressive symptoms. Serum uric acid (SUA), an antioxidant, may be involved in the occurrence and development of depressive symptoms, but the mechanism remains unknown. Moreover, the relationship between structural brain networks and SUA has not been explored.

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Hypertension is a leading cause of cerebral small vessel disease (CSVD) and vascular dementia in elderly individuals. We aimed to assess cerebral perfusion and dynamic changes in brain structure in stroke-prone renovascular hypertensive rats (RHRSPs) with different durations of hypertension and to investigate whether they have pathophysiological features similar to those of humans with CSVD. The RHRSP model was established using the two-kidney, two-clip (2k2c) method, and the Morris water maze (MWM) test, MRI, immunohistochemistry, and biochemical analysis were performed at multiple time points for up to six months following the 2k2c operation.

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Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic complications, malignancy, long-term outcomes and histopathologic changes of native bladder and the augmented intestine after AC in children with neurogenic bladder. Pediatric patients < 18 years who underwent AC between 2000 and 2020 were enrolled.

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Objective: Progressive infarction (PI) has a negative effect on functional prognosis. Our study aimed to develop and validate a risk score for predicting PI in patients with anterior circulation single subcortical infarction (ACSSI).

Methods: Between January 2020 and October 2022, we retrospectively enrolled 638 eligible patients with ACSSI.

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Background: Currently, ischemic stroke is the leading cause of death in China. To compare regional differences of ischemic stroke, we analyzed the clinical characteristics of patients with ischemic stroke in four regionally representative hospitals in China.

Methods: We conducted a retrospective study at four tertiary hospitals in east China, with regionally representative patients.

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Background: Discontinuation of the deep medullary veins (DMVs) may be an early imaging marker for identifying cognitive impairment caused by cerebral small vessel disease (CSVD). However, this method lacks mechanistic exploration. We aimed to investigate whether the DMV score is related to CSVD imaging markers and cognitive impairment in patients with CSVD.

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Hyperlipidemia (HLP) is a prevalent metabolic disorder and a significant risk factor for cardiovascular disease. According to recent discoveries, super-enhancers (SEs) play a role in the increased expression of genes that encode important regulators of both cellular identity and the progression of diseases. However, the underlying function of SEs in the development of HLP is still unknown.

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Introduction: IVT use declined globally in 2020 due to the Corona Virus Disease 2019 (COVID-19) pandemic, but it increased in South China. This study was conducted to evaluate the association of establishing Stroke Prevention Centers (SPCs) at primary hospitals with IVT increase in South China.

Materials And Methods: We conducted a longitudinal observational study across 336 hospitals in 114 areas in South China during 2020-2022.

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Converting CO to valuable chemicals and fuels is a viable method to establish a carbon-neutral energy cycle in the environment. Metal-organic frameworks (MOFs), characterized by dispersed active sites, high porosity, etc., have displayed a great application prospect in the electrochemical/chemical CO reduction reaction (CORR) process.

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Background: Premature ejaculation (PE) is one of the most common male sexual dysfunctions with prominent psychological consequences. Type D personality (TDP) is also associated with multiple psychological disorders, such as depression and anxiety. However, the correlation between PE and TDP remains unknown.

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Purpose: The impact of body mass index (BMI) on patients with upper urinary tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU) is controversial. Increasing evidence suggests an age-dependent relationship between obesity and outcomes for some solid organ tumors. Herein, we aimed to assess the prognostic value of preoperative BMI in UTUC patients treated with RNU in Taiwan.

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Ischemic stroke causes secondary neurodegeneration in the thalamus ipsilateral to the infarction site and impedes neurological recovery. Axonal degeneration of thalamocortical fibers and autophagy overactivation are involved in thalamic neurodegeneration after ischemic stroke. However, the molecular mechanisms underlying thalamic neurodegeneration remain unclear.

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Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a broad range of cellular and metabolic functions carried out in a variety of cellular compartments. In addition to transamidation, TG2 also functions as a Gα signaling protein, a protein disulfide isomerase (PDI), a protein kinase, and a scaffolding protein. In the nucleus, TG2 modifies histones and transcription factors.

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  • * Phylogroup B2 was the most prevalent (64.8%), while phylogroups C and E had the highest rates of multidrug resistance (86.8% and 80.0%, respectively).
  • * The research found that phylogroup B2 had the highest average of virulence genes, while phylogroups A and C exhibited low curli production, and interestingly, phylogroup A E. coli showed the highest virulence against larvae.
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Backgroud: Previous in vitro studies have indicated that pyrimidinergic receptor P2Y6 (P2RY6, P2Y6 receptor) may function as a cancer-promoting factor in lung adenocarcinoma (LUAD). However, the prognostic significance of P2RY6 expression in LUAD has not been investigated.

Objective: This study aimed to assess the impact of P2RY6 expression on the survival of patients with LUAD.

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Background: Developing Internet+home care (IHC) services is a promising way to address the problems related to population aging, which is an important global issue. However, IHC services are in their infancy in China. Limited studies have investigated the willingness and demand of nurses in municipal hospitals to provide IHC services.

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Three novel Co-based coordination polymers including {[Co(L)(μ-O)]} (1), {[Co(L)(bimb)]} (2) and {[Co(L)(bimmb)]} (3) (HL = 2,6-di(4-carboxylphenyl)-4-(4-(triazol-1-ylphenyl))pyridine), bimb = 1,4-bis(lmidazol) butane, bimmb = 1,4-bis(imidazole-1-ylmethyl)benzene) were successfully prepared under solvothermal conditions and characterized. Single-crystal X-ray diffraction analyses revealed that 1 possesses a 3D architecture composed of a trinuclear cluster [CoN(CO)(μ-O)], 2 exhibits a 2D new topological framework with the point symbol (8·12)(8), whereas 3 shows a unique six-fold interpenetrated 3D framework with a (6·8·10)(6)(8) topology. Impressively, all of them can function as a highly selective and sensitive fluorescent sensor for the biomarker methylmalonic acid (MMA) via fluorescence quenching.

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