Publications by authors named "Fan Shu"

Freshwater mussels are an important component of the macrobenthic fauna but due to modern environmental pollution and destruction, the abundance of freshwater mussels has declined rapidly, and this fauna is one of the most threatened animal groups in the world. China is the country with the second highest diversity of freshwater mussels in the world. Rhombuniopsis is a genus of freshwater mussels endemic to the ancient lakes and surrounding area in Yunnan Province, China.

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  • Intestinal dysbiosis and l-tryptophan metabolism issues contribute to the worsening of inflammatory bowel disease (IBD), affecting intestinal barrier function.
  • A new probiotic, EcN-TRP@A/G, is developed to improve tryptophan metabolism and restore gut health by encapsulating an enhanced probiotic with better stability and targeted release.
  • In experiments with IBD mice, this engineered probiotic significantly improves gut permeability, reduces inflammation, and promotes beneficial gut bacteria, offering a potentially cost-effective treatment strategy for IBD.
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  • Researchers are developing a new method for creating artificial heterojunctions from 2D materials to improve device applications by focusing on strong covalent bonds instead of weak van der Waals forces.
  • This new approach enhances charge-transfer dynamics and allows for customizable band structure regulation at the molecular level, making it more efficient and cost-effective.
  • Experimental and theoretical analyses reveal that the efficiency of this method relies on organic electronegativity, leading to great performance in various applications, thereby offering a promising platform for future advanced devices.*
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Background: Clear cell renal cell carcinoma (ccRCC) is a highly aggressive cancer associated with higher death rates. However, traditional anti-angiogenic therapies have limited effectiveness due to drug resistance. Vascular mimicry (VM) provides a different way for tumors to develop blood vessels without relying on endothelial cells or angiogenesis.

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Sensorineural hearing loss is one of the most prevalent sensory deficits. Spiral ganglion neurons (SGNs) exhibit very limited regeneration capacity and their degeneration leads to profound hearing loss. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have been demonstrated to repair tissue damage in various degenerative diseases.

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A ball-mill-enabled nickel-catalyzed 1,4-alkylarylation of 1,3-enynes with organic bromides has been developed, offering a versatile method for assembling tetrasubstituted allenes. This approach, the first of ball-milling-based remote radical coupling, overcomes the limitations of traditional solution-phase methods, such as the need for air- and moisture-sensitive reagents, the use of bulk solvents, and prolonged reaction times. Given the outstanding performance of ball-milling-based radical reduction coupling reactions, we anticipate further advancements in sustainable and efficient synthetic methodologies.

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Background: To prospectively evaluate the technical efficacy and safety of the double-lumen eustachian tube (ET) balloon catheter in patients with ET dysfunction.

Methods: Patients who were diagnosed with ET dysfunction and needed balloon eustachian tuboplasty (BET) were prospectively enrolled. A double-lumen ET balloon catheter was used to dilate the ET and inject medicine.

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Brainoid computing using 2D atomic crystals and their heterostructures, by emulating the human brain's remarkable efficiency and minimal energy consumption in information processing, poses a formidable solution to the energy-efficiency and processing speed constraints inherent in the von Neumann architecture. However, conventional 2D material based heterostructures employed in brainoid devices are beset with limitations, performance uniformity, fabrication intricacies, and weak interfacial adhesion, which restrain their broader application. The introduction of novel 2D atomic-molecular heterojunctions (2DAMH), achieved through covalent functionalization of 2D materials with functional molecules, ushers in a new era for brain-like devices by providing both stability and tunability of functionalities.

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  • Heart transplantation is a vital option for patients with severe heart failure, but challenges like ischemia-reperfusion injury (IRI) and immune responses complicate recovery.* -
  • Existing treatments focus mainly on adaptive immunity, leaving gaps in managing IRI and innate immune activation, which are critical for successful transplants.* -
  • A new therapy using reactive oxygen species-responsive nanovesicles carrying rapamycin (FNVs@RAPA) shows potential in reducing early IRI and immune rejection by targeting inflammatory macrophages at the heart graft, improving transplant outcomes.*
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While surgical resection is the predominant clinical strategy in the treatment of melanoma, postoperative recurrence and undetectable metastasis are both pernicious drawbacks to this otherwise highly successful approach. Furthermore, the deep cavities result from tumor excision can leave long lasting wounds which are slow to heal and often leave visible scars. These unmet needs are addressed in the present work through the use of a multidimensional strategy, and also promotes wound healing and scar reduction.

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Introduction: Multiple myeloma (MM) is a malignant plasma cell disease caused by abnormal proliferation of clonal plasma cells in bone marrow. Upfront identification of tumor subgroups with specific biological markers has the potential to improve biologically-driven therapy. Previously, we established a molecular classification by stratifying multiple myeloma into two subtypes with a different prognosis based on a gene module co-expressed with MCL-1 (MCL1-M).

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  • This study investigated the effectiveness of 3D T2-weighted MRI and high-resolution CT scans in diagnosing cochlear fibrosis linked to Streptococcus suis meningitis.
  • Four patients with hearing loss despite antibiotic treatment were evaluated using clinical imaging and post-surgical assessments.
  • Results showed that T2MRI was more sensitive than HRCT in detecting cochlear issues, and cochlear implantation was successfully performed, indicating that CI is a viable treatment option even in severe fibrosis cases.
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Immunotherapy represented by programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) monoclonal antibodies has led tumor treatment into a new era. However, the low overall response rate and high incidence of drug resistance largely damage the clinical benefits of existing immune checkpoint therapies. Recent studies correlate the response to PD-1/PD-L1 blockade with PD-L1 expression levels in tumor cells.

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Objective: To investigate whether there is a correlation between the inflammatory state and the pathogenesis and clinical features of sudden hearing loss (SHL) by studying the expression of inflammation-related cytokines in the peripheral blood of patients with SHL.

Methods: In this work, we analyzed the cytokine profiles of 48 analytes in 38 patients with SHL compared to 38 healthy donors using a multiplex immunoassay. This study used appropriate statistical methods to screen for inflammatory cytokines associated with the pathogenesis of SHL, to analyze their network correlation, and to analyze the relationship between clinical features of SHL and inflammatory cytokines.

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  • Pressure sensors are essential in various industries like aerospace, automotive, medical, and consumer electronics, with emerging trends focusing on enhanced sensitivity and accuracy.
  • Recent innovations include new types of MEMS-based pressure sensors such as minute differential pressure sensors, resonant pressure sensors, and leadless designs, all aimed at improved performance and miniaturization.
  • The paper also examines advancements in fabrication methods and sensor integration, highlighting designs that offer exceptional sensitivity for applications like medical ventilators and high-accuracy operations with materials like silicon and quartz.
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Bacterial infections often involve virulence factors that play a crucial role in the pathogenicity of bacteria. Accurate detection of virulence factor genes (VFGs) is essential for precise treatment and prognostic management of hypervirulent bacterial infections. However, there is a lack of rapid and accurate methods for VFG identification from the metagenomic data of clinical samples.

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  • Syphilis can cause membranous nephropathy, which is a condition that leads to nephrotic syndrome characterized by significant protein loss in urine.* -
  • A case study described a patient whose renal biopsy displayed a 'full house' immunohistochemical pattern, initially misdiagnosed and treated for other types of nephropathies.* -
  • After confirming syphilis and treating the patient with benzathine penicillin, the nephrotic syndrome resolved quickly, highlighting syphilis as an important but often overlooked cause of this condition.*
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Background: Rhinoplasty is one of the most challenging plastic surgeries because it lacks a uniform standard for preoperative design or implementation. For a long time, rhinoplasties were done without an accurate consensus of aesthetic design between surgeons and patients before surgery and consequently brought unsatisfactory appearance for patients. In recent years, three-dimensional (3D) simulation has been used to visualize the preoperative design of rhinoplasty, and good results have been achieved.

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Purpose: Autism spectrum disorder (ASD) affects one in 66 children in Canada, and its symptoms may be particularly challenging for parents from a Chinese background. Further, when working with Chinese families, Western-educated service providers may experience difficulty in applying culturally relevant and family-centered care. This study examined the experiences of one Chinese-Canadian family as they receive intervention services for their two children with ASD.

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Background And Aims: The intratumoral microbiome has been reported to regulate the development and progression of cancers. We aimed to characterize intratumoral microbial heterogeneity (IMH) and establish microbiome-based molecular subtyping of HBV-related HCC to elucidate the correlation between IMH and HCC tumorigenesis.

Approach And Results: A case-control study was designed to investigate microbial landscape and characteristic microbial signatures of HBV-related HCC tissues adopting metagenomics next-generation sequencing.

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Objective: Stroke, a common illness in older adults, accounts for up to 4% of direct medical costs in developed nations. Informal caregiving contributing a significant proportion of economic burden post-stroke warrants a deeper understanding of the caregiving context to sustain caregiving arrangement. While literature exists describing differences in motivation and preferences of caregivers, limited literature explores differences in caregiving experiences of different types of caregivers (ie, spouse, adult-child, sibling or others).

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Facing the explosive growth of data, a number of new micro-nano devices with simple structure, low power consumption, and size scalability have emerged in recent years, such as neuromorphic computing based on memristor. The selection of resistive switching layer materials is extremely important for fabricating of high performance memristors. As an organic-inorganic hybrid material, metal-organic frameworks (MOFs) have the advantages of both inorganic and organic materials, which makes the memristors using it as a resistive switching layer show the characteristics of fast erasing speed, outstanding cycling stability, conspicuous mechanical flexibility, good biocompatibility, etc.

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