Publications by authors named "Fan Feng"

Introduction: O'Donnell-Luria-Rodan (ODLURO) syndrome is an autosomal dominant disorder associated with KMT2E gene variants. ODLURO syndrome is characterized mainly by developmental delay, intellectual disability and macrocephaly or microcephaly; in some patients, it may manifest as autism or epilepsy.

Methods: Trio whole-exome sequencing was performed on a female infant with unexplained West syndrome and developmental regression.

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Manual therapy has been extensively utilized in the clinical management of hand spasticity. Clinicians face challenges in accurately evaluating spasticity during manual therapies due to its dynamic changes, resulting in a heavy reliance on therapists' experience for assessing and adjusting the therapy process. Currently, the Modified Ashworth Scale (MAS) and surface electromyography (sEMG) have been widely used to evaluate spasticity.

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The Journal retracts the article "MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line" [...

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Background And Purpose: Gastric cancer is a kind of malignant tumor with high incidence and high mortality, which has strong tumor heterogeneity. A classic Chinese medicine, (PT), was shown to exert therapeutic effects on gastric cancer cells. However, its chemical and pharmacological profiles remain to be elucidated.

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Aims: We aimed to develop Ferroptosis-Related Gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with colorectal cancer (CRC).

Background: Prediction of CRC prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains unexplored.

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Doping and surface-modification are well-established strategies for the performance enhancement of bismuth vanadate (BiVO) photoanodes in photoelectrochemical (PEC) water splitting devices. Herein, a "double-use" strategy for the development of high-performance BiVO photoanodes for solar water splitting is reported, where a molecular cobalt-phosphotungstate (CoPOM = Na[Co(HO)(PWO)]) is used both as a bulk doping agent as well as a surface-deposited water oxidation cocatalyst. The use of CoPOM for bulk doping of BiVO is shown to enhance the electrical conductivity and improve the charge separation efficiency, resulting in the enhancement of the maximum applied-bias photoconversion efficiency (ABPE) by a factor of ∼18 to 0.

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Dynamic functional connectivity (DFC) has shown promise in the diagnosis of Autism Spectrum Disorder (ASD). However, extracting highly discriminative information from the complex DFC matrix remains a challenging task. In this paper, we propose an ASD classification framework PSA-FCN which is based on time-aligned DFC and Prob-Sparse Self-Attention to address this problem.

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Nitrogen fixation is essential for the sustainable development of both human society and the environment. Due to the chemical inertness of the N≡N bond, the traditional Haber-Bosch process operates under extreme conditions, making nitrogen fixation under ambient conditions highly desirable but challenging. In this study, we present an ultrasonic atomizing microdroplet method that achieves nitrogen fixation using water and air under ambient conditions in a rationally designed sealed device, without the need for any catalyst.

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To evaluate the safety and efficacy of staged coiling followed by flow diverter (FD) in the treatment of ruptured intracranial aneurysms(RIAs). A retrospective analysis was conducted on 20 patients with RIAs treated with staged coiling followed by FD at a single center, between April 2015 and September 2024. Patient demographics, aneurysm characteristics, clinical and imaging outcomes were reviewed.

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Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers.

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In order to realize high-performance bulk-heterojunction (BHJ) all-polymer solar cells, achieving appropriate aggregation and moderate miscibility of the polymer blends is one critical factor. Herein, this study designs and synthesizes two new polymer acceptors (Ps), namely PYF and PYF-Cl, containing benzo[1,2-b:4,5-b'] difuran (BDF) moiety with/without chlorine atoms on the thiophene side groups. Thanks to the preferred planar structure and high electronegativity of the BDF units, the resultant Ps generate strong intermolecular interactions and π-π stacking in both the neat and blend films.

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Article Synopsis
  • The development of membranes for post-combustion carbon capture faces challenges such as the trade-off between permeance and selectivity, as well as high temperature resilience.
  • Mixed matrix membranes (MMMs) made from polymers and metal-organic frameworks (MOFs) could solve these issues, but they struggle with low MOF loading in thin layers.
  • The proposed inverse synthesis strategy allows for high MOF loading (up to 40 wt%) in polymer coatings, significantly enhancing CO permeance and maintaining selectivity at elevated temperatures, paving the way for energy-efficient carbon capture technologies.
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Purpose: Floating hip is a severe high-energy injury. Femoral fracture is an essential component of floating hip. However, few studies have addressed the relationship between the femoral fracture pattern and floating hip injury.

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Introduction: Tunnel composting technology for preparing cultivation media can achieve a higher biological efficiency (BE) and a lower contamination rate (CR). However, this technology lacks in-depth and systematic study.

Methods: In the present study, the changes in the microbiome and microbial metabolic functions were surveyed using metagenomic analysis.

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Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers, enabling the integration of multiple data types.

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The endosperm of cereal grains feeds the entire world as a major food supply; however, little is known about its defence response during endosperm development. The Inducer of CBF Expression 1 (ICE1) is a well-known regulator of cold tolerance in plants. ICE1 has a monocot-specific homologue that is preferentially expressed in cereal endosperms but with an unclear regulatory function.

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This research examined the varying susceptibility of pure copper (Cu), 90/10 copper-nickel (Cu-Ni) alloy, 70/30 Cu-Ni alloy, and pure nickel (Ni) to microbiologically influenced corrosion (MIC) induced by Desulfovibrio vulgaris, with a focus on the elemental composition of the materials. The results revealed a progressive shift in MIC behavior across these metals and alloys, with increased corrosion severity observed as Ni content decreased. Element Ni improved the corrosion resistance of the alloy while also preventing the growth of microorganisms.

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Article Synopsis
  • * This study investigated the effects of anlotinib, a molecular-targeted drug, in combination with radiofrequency ablation (RFA) on MTC and found significant antitumor activity in MTC cell lines and tissues.
  • * The research suggests that using anlotinib alongside RFA could enhance treatment outcomes for patients with MTC, presenting a potentially effective new therapeutic strategy.
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Photodynamic therapy (PDT) utilizing metal-organic frameworks (MOFs) has developed as a new and efficacious treatment for malignant tumors located on the surface of the human body. In order to achieve more effective PDT treatment outcomes, the traditional method has been to increase the intensity of the laser irradiation, but this approach can easily lead to tissue burns. In this study, we developed a new type of nanoparticle, F68-PKI@PCN224, aims to achieve effective PDT upon medullary thyroid carcinoma (MTC) which is an uncommon form of thyroid cancer that originates in the parafollicular cells of the thyroid and the therapeutic outlook for patients with MTC remains unsatisfactory.

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Article Synopsis
  • * NOX nanozymes serve as a more stable and cost-effective alternative, with potential applications in bio-sensing, antibacterial treatments, anti-aging, and anticancer therapies.
  • * Future research should focus on overcoming challenges like optimizing catalytic efficiency, ensuring safety in biological systems, and exploring new materials to enhance NOX nanozymes' capabilities, alongside collaborative efforts in nanotechnology and medicine.
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Brain tumors pose formidable challenges in oncology due to the intricate biology and the scarcity of effective treatment modalities. The emergence of immunotherapy has opened new avenues for innovative therapeutic strategies. Chimeric antigen receptor, originally investigated in T cell-based therapy, has now expanded to encompass macrophages, presenting a compelling avenue for augmenting anti-tumor immune surveillance.

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Background: Long-term heat stress (HS) severely restricts the growth performance of beef cattle and causes various health problems. The gut microbiota plays a crucial role in HS-associated inflammation and immune stress involving lymphocyte function. This study investigated the effects of dietary tea polysaccharide (TPS), a natural acidic glycoprotein, on HS-induced anorexia, inflammation, and gut microbiota dysbiosis in Simmental beef cattle.

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Article Synopsis
  • There is a connection between lung adenocarcinoma (LUAD) and tuberculosis (TB), with TB increasing the risk of developing LUAD, though the specifics of how TB contributes to this cancer are still unclear.
  • Researchers identified shared differentially expressed genes (DEGs) from lung samples of both TB and LUAD patients, classifying these into three molecular subtypes with distinct clinical features and pathways, and created prognostic models based on TB signatures.
  • The study demonstrated that a unique TB-related signature can predict immunotherapy responses and revealed new markers associated with the progression of lung adenocarcinoma, highlighting the potential role of TB in this cancer's development.
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Synopsis of recent research by authors named "Fan Feng"

  • Fan Feng's recent research primarily focuses on innovative cancer therapies, including the integration of molecular-targeted drugs and advanced treatment methods like radiofrequency ablation and photodynamic therapy for improving outcomes in Medullary Thyroid Carcinoma and glioblastoma.
  • The research also explores novel approaches using nanotechnology, such as NADH oxidase nanozymes and biodegradable microneedles, to enhance treatment efficacy and manage cancer recurrence.
  • Additionally, Fan Feng investigates broader implications of cellular interactions and dietary impacts on health, including the role of tea polysaccharides in managing heat stress in cattle and the connections between tuberculosis and lung cancer, showcasing a comprehensive approach to targeting disease mechanisms.

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