Ternary recognition fluorescent probe for lysosome acidification counter-ion studies Cl, K, and pH.

Lysosomal acidity relies on H inflow, which requires counter-ion flows (Cl and K) to balance charge. A lysosome targeting ternary recognition fluorescent probe for Cl, K, and pH was developed for lysosome acidification counter-ion research. The probe was used to study counter-ion changes when the Cl channel was blocked and under oxidative pressure.

A "dual-key-and-lock" ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins.

TMR-TPE, a ratiometric fluorescent probe, was reported for the imaging of vicinal dithiol proteins (VDPs) in living cells. Profiting from the "dual-key-and-lock" design, TMR-TPE solves the toxicity problem of VDP probes (98% cell viability at 50 μM) and avoids the interference of small thiols (up to 10 mM GSH). The change of VDPs during drug-induced liver injury was monitored for the first time using TMR-TPE.

Can human activities enhance the trade-off intensity of ecosystem services in arid inland river basins? Taking the Taolai River asin as an example.

Driven by economic and social factors, more and more human beings intervene in nature to promote rapid economic and social development at the expense of ecosystem services (ES), which inevitably leads to the occurrence and even aggravation of ES trade-offs. Especially in the arid inland river basin is more serious. Therefore, this paper takes the Taolai River Basin as an example and uses the InVEST model to evaluate the spatial distribution of four typical ES, including carbon sequestration, oxygen release, windbreak and sand fixation, and water production, under the potential-actual states of the watershed.

Strengthening container shipping network connectivity during COVID-19: A graph theory approach.

A container shipping network connects coastal countries with each other and facilitates most of the world merchandise trade. Reliable maritime connectivity ensures the availability of commodities and economic growth. The global spread of COVID-19 has led to port failures and service cancellations, resulting in decreased connectivity level of container ports.

Accurate Forecasting of Emergency Department Arrivals With Internet Search Index and Machine Learning Models: Model Development and Performance Evaluation.

Background: Emergency department (ED) overcrowding is a concerning global health care issue, which is mainly caused by the uncertainty of patient arrivals, especially during the pandemic. Accurate forecasting of patient arrivals can allow health resource allocation in advance to reduce overcrowding. Currently, traditional data, such as historical patient visits, weather, holiday, and calendar, are primarily used to create forecasting models.

Multiscale Cross-Connected Dehazing Network With Scene Depth Fusion.

In this article, we propose a multiscale cross-connected dehazing network with scene depth fusion. We focus on the correlation between a hazy image and the corresponding depth image. The model encodes and decodes the hazy image and the depth image separately and includes cross connections at the decoding end to directly generate a clean image in an end-to-end manner.

Interfacial Laser-Induced Graphene Enabling High-Performance Liquid-Solid Triboelectric Nanogenerator.

Laser-induced graphene (LIG) has emerged as a promising and versatile method for high-throughput graphene patterning; however, its full potential in creating complex structures and devices for practical applications is yet to be explored. In this study, an in-situ growing LIG process that enables to pattern superhydrophobic fluorine-doped graphene on fluorinated ethylene propylene (FEP)-coated polyimide (PI) is demonstrated. This method leverages on distinct spectral responses of FEP and PI during laser excitation to generate the environment preferentially for LIG formation, eliminating the need for multistep processes and specific atmospheres.

Noncoplanar Versus Coplanar Intensity-Modulated Radiation Therapy (IMRT) for Protection of the Lip and Buccal Mucosa.

Objective: In this study, by comparing coplanar and noncoplanar intensity-modulated radiation therapy (IMRT) treatment planning in treating tongue cancer, the significance of noncoplanar fields in the protection of the lip and buccal mucosa was determined, and a reasonable solution was selected.

Methods: Forty-eight tongue cancer patients treated from June 2019 to February 2021 were selected and randomly divided into a coplanar field group and a noncoplanar field group. The mucosal dose limit changed from 15 Gy to 45 Gy for comparison of the two treatment plans.

Locally Weighted Principal Component Analysis-Based Multimode Modeling for Complex Distributed Parameter Systems.

Global principal component analysis (PCA) has been successfully introduced for modeling distributed parameter systems (DPSs). In spite of the merits, this method is not feasible due to parameter variations and multiple operating domains. A novel multimode spatiotemporal modeling method based on the locally weighted PCA (LW-PCA) method is developed for large-scale highly nonlinear DPSs with parameter variations, by separating the original dataset into tractable subsets.

Single dose testosterone administration enhances novelty responsiveness and short-term habituation in healthy males.

The role of testosterone in sensory perception suggests that testosterone likely regulates adaptive responses to sensory changes, including habituation to repeated events and responsiveness to novel events. To test this hypothesis, we investigated how testosterone modulates brain responses to rapid changes in sensory inputs. Using a double-blind, placebo-controlled, within-participant design, each participant received a single dose of either testosterone or placebo, and then completed a passive auditory oddball task in which infrequent deviant tones were embedded in a series of frequent standard tones.

[Experimental Study of MAR Algorithm in Metal Artifact Removal of CT Simulator].

Objective: To explore the application value of MAR algorithm in metal artifact removal of CT simulator.

Methods: CT phantom with titanium plate was scanned using conventional algorithms and MAR algorithms, respectively. Artifact index(), contrast-to-noise ratio() and values at different slices were used to analyze the artifact images.

[Research on Fault Risk Identification and Control of CT Simulator Based on FMEA].

Objective: To explore the high-risk fault risk of CT simulator and the main causes of the risk, and to put forward effective risk management strategies.

Methods: The failure mode and effect analysis method was used to identify and control the operational fault risk of CT simulator.

Results: 5 major fault components, 8 fault failure models and 17 failure causes were analyzed.

Others' Pain Appraisals Modulate the Anticipation and Experience of Subsequent Pain.

The present study investigated how pain appraisals from other individuals modulated self-pain anticipation and perception. Appraisals of pain intensity from 10 other individuals were presented before the participants received identical electrical pain stimulation themselves. In reality, the presented other's pain appraisals, with either low or high in mean and variance, were generated by the experimenter, and were randomly paired with the subsequent electrical stimulation at either low or high intensity.

[Research on the Evaluation System of Clinical Value of Digital Radiography].

Objective: To establish a set of evaluation system of digital radiography clinical value and provide foundation for the maturity assessment of digital radiography.

Methods: The evaluation system of clinical value of digital radiography was established by literature survey,expert consultation,and percentage weight method.

Results: The expert authority coefficients were 0.

Hearing other's pain is associated with sensitivity to physical pain: An ERP study.

Numerous studies have demonstrated an overlap between the processing of self-pain and others' pain, which suggests that psychological and neural representations are shared between the perception of physical pain and empathy for pain. As hearing emotional exclamations is a common way in which we regularly perceive and empathize with others' pain, the present study aimed to investigate the link between sensitivity to physical pain and the sounds made by others in pain. We recorded event-related potential (ERP) responses to another person's vocalizations (neutral or painful intonation) and identified electrophysiological responses associated with the processing of painful sounds.

Metasurface-based broadband orbital angular momentum generator in millimeter wave region.

Orbital angular momentum (OAM) is an intrinsic property that all electromagnetic waves can carry. Interesting properties of OAM beams have enabled many novel applications. But broadband OAM generator has rarely been investigated, especially in the millimeter wave frequency band.

[The Clinical Status and Process of Hydrosurgery System].

This paper reviews the principle and clinical application of hydrosurgery system, including the burn debridement, diabetic foot wounds debridement and other trauma debridement. Meanwhile, this paper introduces the development direction of waterjet technology. Furthermore, the safety, effectiveness and suitability can be discussed.

[Assessment of Technology and Clinical Application of Hydrosurgery System].

This paper introduces the technical features of hydrosurgery system and evaluates it from three aspects:safety and effectiveness, economy and technology maturity. The evaluation results show that the safety and effectiveness are high, and the safety mainly involves the misuse of the system, which cause the adverse events. A large number of literatures have proved that the system is more suitable for the debridement of fine parts.

An Intelligent Decision System for Intraoperative Somatosensory Evoked Potential Monitoring.

Somatosensory evoked potential (SEP) is a useful, noninvasive technique widely used for spinal cord monitoring during surgery. One of the main indicators of a spinal cord injury is the drop in amplitude of the SEP signal in comparison to the nominal baseline that is assumed to be constant during the surgery. However, in practice, the real-time baseline is not constant and may vary during the operation due to nonsurgical factors, such as blood pressure, anaesthesia, etc.

[Calculation of MR radiofrequency specific energy absorption rate and clinical application].

This paper reviews the basic principles and calculation methods of MR specific absorption rate, discusses the clinical application of MR specific absorption rate.

Postmarketing surveillance study of OxyContin tablets for relieving moderate to severe postherpetic neuralgia pain.

Objective: To evaluate the efficacy and safety of OxyContin tablets(controlled-release oxycodone hydrochloride: 5, 10, 20, and 40 mg) in relieving moderate to severe postherpetic neuralgia (PHN) pain.

Method: A multicenter, open-label, prospective, self-controlled clinical observation.

Results: Pain was relieved in 17.