Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics.

Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differentially expressed proteins (DEPs) and then evaluate the potential plasma biomarkers between CMS and non-CMS groups. A total of 145 DEPs were detected in CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly up-regulated and 56 were significantly down-regulated.

[Correlation between the Expression of microRNA 451 in Red Blood Cells and Chronic Mountain Sickness].

Objective: To investigate the correlation between the expression of microRNA-451 in red blood cells and chronic mountain sickness(CMS).

Methods: Peripheral blood samples were collected from emigrant CMS patients (28 cases), localized CMS patients (12 case), emigrant healthy people (24 case) and localized healthy people (22 case). The microRNA-451 expression in red blood cells was measured by the RT-PCR.