Clinical, magnetic resonance imaging, histopathological features, treatment options and outcome of spinal ependymoma in dogs: 8 cases (2011-2022).

Objectives: This study aims to report on the clinical magnetic resonance imaging, histological features, treatment options and outcomes of spinal ependymomas in dogs.

Materials And Methods: Retrospective evaluation of medical records from dogs histologically confirmed spinal ependymomas with clinical presentations, magnetic resonance imaging findings, histological aspects, treatment options and outcomes.

Results: Eight dogs presented with acute to subacute onset of para- or tetraparesis.

Cytotoxicity on low-grade canine meningioma with the use of somatostatin analog (octreotide): An in vitro study.

Background: Meningioma is the most common tumor of the central nervous system of dogs. For this tumor, surgery remains the treatment of choice, either alone or in combination with radiotherapy. Unfortunately, chemotherapeutic strategies are practically absent in dogs and palliative therapies are the only option to surgery.

A multimodal approach to diagnosis of neuromuscular neosporosis in dogs.

Background: Early diagnosis of neosporosis in dogs is challenging.

Objectives: To evaluate the feasibility of a compound multimodal testing approach for diagnosing in dogs neuromuscular and combined forms of neosporosis.

Animals: A total of 16 dogs diagnosed with solely neuromuscular neosporosis or with a combination of neuromuscular and central nervous system neosporosis.

Advancing Methodologies for Investigating PM Removal Using Green Wall System.

Combustion processes are the primary source of fine particulate matter in indoor air. Since the 1970s, plants have been extensively studied for their potential to reduce indoor air pollution. Leaves can retain particles on their surfaces, influenced by factors such as wax content and the presence of hairs.

Comparison of Two Surgical Techniques for the Treatment of Canine Disc Associated-Cervical Spondylomyelopathy.

Objective: To compare prosthetic disc and vertebral distraction stabilization in dogs with disc-associated cervical spondylomyelopathy (DA-CSM).

Study Design: A retrospective clinical study.

Animals: 25 dogs.

An Adaptation and Validation Study of the Speech, Spatial, and Qualities of Hearing Scale (SSQ) in Italian Normal-Hearing Children.

This study aimed to translate and adapt the English version of the Speech, Spatial, and Qualities of Hearing Scale (SSQ) for children and for parents into the Italian language; validate SSQ for hearing children and their parents; and evaluate the discriminant validity of the instrument. A group of 102 normal-hearing Italian children, aged between 9 and 16 years, and their parents were included in this study. A group of 31 parents of normal-hearing Italian children aged between 6 and 8 years was also included.

Occipital cranioplasty using customized titanium prosthesis yields successful outcome in association with foramen magnum decompression in dogs suffering by Chiari-like malformation.

Objective: To describe the use of a customized 3-D-printed titanium prosthesis as adjunctive treatment for foramen magnum decompression (FMD) in dogs with Chiari-like malformation (CM) and syringomyelia (SM).

Animals: 8 dogs with clinical signs and MRI findings of CM-SM.

Procedures: 3-D reconstruction of CT images of the head was used to simulate an occipital craniectomy and design the prosthesis.

Clinical features of muscle cramp in 14 dogs.

Background: Muscle cramps (MCs) are prolonged, involuntary, painful muscle contractions characterized by an acute onset and short duration, caused by peripheral nerve hyperactivity.

Objectives: To provide a detailed description of the clinical features and diagnostic findings in dogs affected by MCs.

Animals: Fourteen dogs.

Clinical, magnetic resonance imaging and histologic findings of canine thoracolumbar discal pseudocyst: 8 cases (2014-2019).

Objective: To report the clinical and MRI features, and histologic findings of thoracolumbar discal pseudocyst in dogs.

Materials And Methods: The records of eight dogs with thoracolumbar discal cyst-like structures were retrospectively collected to record their clinical signs, MRI features and surgical and histologic findings.

Results: Eight dogs with surgically and histologically confirmed thoracolumbar discal pseudocysts were included in the case series.

Impact of Source Position and Obstructions on Fume Hood Releases.

A fume hood is the most central piece of safety equipment available to researchers in a laboratory environment. While it is understood that the face velocity and sash height can drastically influence airflow patterns, few specific recommendations can be given to the researcher to guide them to maximize the safety of their particular hood. This stems from the issue that fundamentally little is known regarding how obstructions within the hood can push potentially harmful particles or chemicals out of the fume hood and into the breathing zone.

Canine Cerebral Intravascular Lymphoma: Neuropathological and Immunohistochemical Findings.

Intravascular lymphoma (IVL) is a rare angiotropic large-cell lymphoma in which neoplastic lymphocytes proliferate within the lumina of small blood vessels in the absence of a primary extravascular mass or leukemia. This study included 10 cases of canine IVL restricted to the CNS. Dogs had an average age of 8 years and neurological signs mainly referred to brain involvement such as depression, seizures, and ambulatory deficits.

Neuroaxonal Dystrophy and Cavitating Leukoencephalopathy of Chihuahua Dogs.

A novel form of neuroaxonal dystrophy is described in 3 Chihuahua pups, 2 of which were from the same litter. It was characterized not only by accumulation of numerous and widely distributed axonal swellings (spheroids) but also by a severe cavitating leukoencephalopathy. The dogs presented with progressive neurological signs, including gait abnormalities and postural reaction deficits.

Canine acute cervical myelopathy: Hydrated nucleus pulposus extrusion or intraspinal discal cysts?

Objective: To differentiate between hydrated nucleus pulposus extrusion and ventral intraspinal discal cysts in dogs.

Study Design: Prospective case series.

Animals: Twenty dogs with acute onset of cervical myelopathy due to hydrated nucleus pulposus extrusion or ventral intraspinal discal cysts.

Magnetic resonance imaging, treatment and outcome of canine vertebral chondrosarcomas. Six cases.

Objectives: To report the clinical presentation, magnetic resonance imaging features, treatments and outcomes of canine vertebral chondrosarcoma.

Materials And Methods: Retrospective review of medical records of dogs with confirmed vertebral chondrosarcoma and magnetic resonance imaging of the lesions, from four different veterinary referral institutions.

Results: A total of six dogs were included in this report.

Health Effects Associated with Wastewater Treatment, Reuse, and Disposal.

A review of the literature published in 2015 on topics relating to public and environmental health risks associated with wastewater treatment, reuse, and disposal is presented. This review is divided into the following sections: wastewater management, microbial hazards, chemical hazards, wastewater treatment, wastewater reuse, agricultural reuse in different regions, greywater reuse, wastewater disposal, hospital wastewater, industrial wastewater, and sludge and biosolids.

Empowering the family during the first months after identification of permanent hearing impairment in children.

The latest international guidelines highlight the importance of involving the family in the diagnostic and rehabilitation process of children affected by permanent hearing impairment. This emphasises how meaningful this approach is for the development of the deaf child. So far, there is very little evidence about this approach in Italy, and there are still some barriers to its practical management.

Achieving early functional auditory access in paediatric cochlear implantation.

Cochlear implantation (CI) is a viable option for providing access to auditory stimulation in severe-to-profound hearing loss/impairment of cochlear origin. It has been demonstrated that CI is safe and effective for deaf children. Younger age at activation after CI is linked with better outcomes.

Dorsal midbrain syndrome associated with persistent neck extension: Clinical and diagnostic imaging findings in 2 dogs.

Two young dogs were evaluated for an acute onset of abnormal head posture and eye movement. Neurological examination was characterized mostly by permanent neck extension, abnormalities of pupils, and eye movement. A mesencephalic mass lesion was detected on magnetic resonance imaging in both cases.

Blindness and behavioural changes in the cat: common neurological causes.

Practical Relevance: Blindness and behavioural changes occur relatively commonly in cats, either separately or in combination, causing devastating consequences for the cat and owner. Blindness can be caused by primary ophthalmic, metabolic or intracranial disease. Similarly behavioural changes may be the primary result of intracranial or systemic disease, but also occur secondarily to visual deficits or changes in interaction with the external environment (ie, non-medical problems).

Functional and structural characterization of the 2/2 hemoglobin from Synechococcus sp. PCC 7002.

Cyanobacterium Synechococcus sp. PCC 7002 contains a single gene (glbN) coding for GlbN, a protein of the 2/2 hemoglobin lineage. The precise function of GlbN is not known, but comparison to similar 2/2 hemoglobins suggests that reversible dioxygen binding is not its main activity.

Oral contraceptive pill use and abnormal menstrual cycles in women with severe condylar resorption: a case for low serum 17beta-estradiol as a major factor in progressive condylar resorption.

Introduction: Progressive condylar resorption has been described for many years. Because condylar resorption favors women over men, many have thought that a prominent systemic factor for the pathogenesis of this disease might be related to sex hormones.

Methods: Over a 3-year period, 27 women without autoimmune disease came to our office for orthognathic surgical correction of their skeletal deformity secondary to severe condylar resorption.

(1)H, (15)N, and (13)C resonance assignments of the 2/2 hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 in the ferric bis-histidine state.

The hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 is a monomeric 123-residue Group I 2/2 hemoglobin. Here, we report (1)H, (15)N, and (13)C assignments for the ferric (low-spin, S = (1/2)) protein with a b heme cofactor and after post-translational modification leading to a c-like heme.

Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.

The catalytic efficiency of the class D beta-lactamase OXA-10 depends critically on an unusual carboxylated lysine as the general base residue for both the enzyme acylation and deacylation steps of catalysis. Evidence is presented that the interaction between the indole group of Trp154 and the carboxylated lysine is essential for the stability of the posttranslationally modified Lys70. Substitution of Trp154 by Gly, Ala, or Phe yielded noncarboxylated enzymes which displayed poor catalytic efficiencies and reduced stability when compared to the wild-type OXA-10.

Matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in canine and feline meningioma.

Fifty-one meningiomas obtained from 28 dogs and 23 cats were selected for this study to investigate the immunohistochemical expression of matrix metalloproteinase (MMP)-2 and MMP-9 and to compare it to the reverse transcriptase subunit of human-telomerase, progesterone receptor expression, and the proliferative index of the tumors, expressed by Ki67 and proliferating cellular nuclear antigen. Paraffin-embedded tumor tissue was obtained from biopsy samples (28 cases) and at necropsy (23 cases). The most common histotype was malignant in dogs (12/28) and transitional in cats (12/23).