Red and Near-Infrared Thermally Activated Delayed Fluorescence Emitters Based on a Dibenzo[f,h]pyrido[2,3-b]quinoxaline Acceptor.

Recently, there has been growing interest in deep red (DR) and near-infrared (NIR) thermally activated delayed fluorescence (TADF) emitters due to their potential use in applications in bioimaging and night-vision displays. Herein, we designed and synthesized a series of red/NIR TADF emitters, DMAC, PXZ, and DPACz, that all contain the same electron-accepting PyBP (dibenzo [f, h] pyrido [2,3-b]quinoxaline) moiety. These compounds emit at 643 nm for DMACPyBP, 722 nm for DPACz PyBP, and 743 nm for PXZPyBP in toluene solution, while their thin films singlet-triplet energy gaps (ΔE) are <0.

Antibiotic Stewardship in Hospital-Acquired Pneumonia.

Background Antimicrobial resistance and incorrect use of antibiotics may worsen hospital-acquired pneumonia (HAP), which is a serious illness associated with healthcare and is related to higher rates of morbidity and death. Objective This study aimed to evaluate the effectiveness of antibiotic stewardship programs (ASPs) in optimizing the treatment of HAP, focusing on improving patient outcomes and reducing resistance. Methodology A prospective cohort study was conducted from August 2022 to July 2023.

In silico homology modeling of dengue virus non-structural 4B (NS4B) protein and its molecular docking studies using triterpenoids.

Background: Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack of adequate treatment. There is an immediate need for the development of effective medication for dengue fever.

Methods: Homology modeling of dengue virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL to predict the 3D structure of the protein.

A nanocomposite competent to overcome solubility and permeation issues of capsaicin and thiocolchicoside simultaneously in gout management: Fabrication of nanocubosomes.

This study aimed to formulate nano-cubosomes (NCs) co-loaded with capsaicin (CAP) and thiocolchicoside (TCS) to enhance their bioavailability and minimize associated potential side effects through transdermal delivery alongside their synergistic activity. Twenty seven (27) nano-cubosomal dispersions were prepared according to Box-Behnken factorial design and the effect of CAP, TCS, glyceryl mono oleate (GMO) and poloxamer 407 (P407) concentrations on particle size, polydispersity index (PDI), zeta potential, and entrapment efficiency were assessed. The results revealed that the optimized formulation exhibited a mean droplet size of 503 ± 10.

Robust iron-doped manganese oxide nanoparticles from facile fabrication to photo-catalytic degradation application of binary dyes mixture.

The manganese oxide (MnO and iron-doped manganese oxide (Fe-MnO) nanoparticles (NPs) with reduced band gap (Eg) were fabricated through the co-precipitation process. They used to degrade Indigo Carmine (IC) and Rhodamine B (RB) binary mixture in an aqueous medium under solar light irradiation. From FT-IR, the twisting modes of the Mn-O bond and the stretching vibrations of the Fe-Mn-O bond were confirmed from the peaks observed at 480 cm,584 cm,675 cm, and 900 cm, 1150 cm, and 1200 cm respectively.

Phosphinecarboxamide based InZnP QDs - an air tolerant route to luminescent III-V semiconductors.

We describe a new synthetic methodology for the preparation of high quality, emission tuneable InP-based quantum dots (QDs) using a solid, air- and moisture-tolerant primary phosphine as a group-V precursor. This presents a significantly simpler synthetic pathway compared to the state-of-the-art precursors currently employed in phosphide quantum dot synthesis which are volatile, dangerous and air-sensitive, P(Si(CH)).

Solar light driven degradation of textile dye contaminants for wastewater treatment - studies of novel polycationic selenide photocatalyst and process optimization by response surface methodology desirability factor.

The unplanned anthropogenic activities and raced industrial revolution detrimentally causes serious threat to terrestrial and aquatic life. A high discharge of wastewater from industries using dyes affects living organisms and the environment. This paper presents studies on polycationic selenides (PCS) synthesized by hydrothermal methods for photocatalytic degradation of dyes.

A Comprehensive Mechanistic Antibacterial and Antibiofilm Study of Potential Bioactive ((BpA)bp)Cu/Zn Complexes via Bactericidal Mechanisms against .

Bacterial resistance to antibiotics and host defense systems is primarily due to bacterial biofilm formation in antibiotic therapy. In the present study, two complexes, bis (biphenyl acetate) bipyridine Cu (II) () and bis (biphenyl acetate) bipyridine Zn (II) (), were tested for their ability to prevent biofilm formation. The minimum inhibitory concentration and minimum bactericidal concentration of complexes and were 46.

Comparative robustness and sustainability of in-situ prepared antimony nanoarchitectonics in chitosan/synthesized carboxymethyl chitosan in environmental remediation perspective.

Due to the rapid race of industrialization natural assets like fresh water has been deteriorated causing lethal effects in living organisms. In the current study robust and sustainable composite of in-situ antimony nanoarchitectonics in chitosan/synthesized carboxymethyl chitosan matrix were synthesized. To improve solubility, metal adsorption and water decontamination, chitosan was modified into carboxymethyl chitosan and the modification was confirmed through various characterization techniques.

Molecular mechanism of Cu metal and drought stress resistance triggered by AGH786 in L.

Rapid industrialization and global warming have threatened the plants with multiple abiotic stresses, such as heavy metals and drought stress. For crop cultivation, the conventional approach of cleaning the soils by excavation is very costly and not feasible for large scale. Establishing toxin-free and drought-resistant crops is a major challenge in the environment under natural and anthropogenic pressure.

Eco-friendly approach for determination of moxifloxacin in pharmaceutical preparations and biological fluids through fluorescence quenching of eosin Y.

An easy, verified spectrofluorimetric approach was established for the investigation of moxifloxacin in pure forms, pharmaceutical preparations, and biological fluids. The approach involves forming a binary complex of moxifloxacin and eosin Y in an acetate buffer with a pH of 3.6.

Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update.

Alzheimer's disease (AD) is one of the main healthcare challenges of the twenty-first century, not only affecting millions of people's quality of life but also increasing the burden on the medical community, families, and society. It is a neurodegenerative disorder characterized by learning and cognitive dysfunction, behavioral turbulence, and memory loss and is a major cause of dementia, contributing to 50-60 % of dementia cases in patients above the age of 65. The major pathophysiological changes include accumulation of beta-amyloid plaques (Aβ), highly phosphorylated tau protein, neuroinflammation, GABA neurotransmission disruption, mitochondrial dysfunction, neuronal damage due to free radicals, and decreased concentration of acetylcholine (ACh) and butyrylcholine (BCh).

Separation studies of concrete and brick from construction and demolition waste.

The quality of recycled aggregates from construction and demolition waste (CDW) is strictly related to the content of porous and low strength phases and is specifically related to the high content of brick particles, despite representing approximately 50 wt.% of the total recycled aggregates. This paper focus on air jigging separation studies for removing brick particles from recycled construction and demolition waste aggregates.

The vespid fauna of Pakistan.

This study provides the first annotated check list of the Vespidae of Pakistan. It is based on the National Insect Museum collection and various studies in Pakistan. Among 105 identified taxa, 77 species and 28 subspecies are recorded in the four subfamilies Eumeninae, Masarinae, Polistinae and Vespinae.

The hawkmoth fauna of Pakistan (Lepidoptera: Sphingidae).

This study represents the first complete modern account of the Sphingidae of Pakistan and takes the form of an annotated checklist, based on several national collections and those of a number of individuals. Of the 60 species and subspecies found, 14 are new records to the fauna of Pakistan, namely Agnosia orneus, Langia zenzeroides subsp. zenzeroides, Polyptychus trilineatus subsp.

Damselflies (Zygoptera: Odonata) of Pakistan: part 1.

The present study is an effort to document bio-geographical distribution for Zygoptera of Pakistan. Damselflies were collected throughout the country and territory of Azad Jammu and Kashmir during 2004-2009. A total of 2692 specimens were collected yielding 9 families, 21 genera, and 48 species and subspecies.

Faunistics of tiger beetles (Coleoptera: Cicindelidae) from Pakistan.

The present biogeographic distribution of tiger beetle fauna is an attempt to register all modern taxa from Pakistan. It includes 55 taxa under 14 genera and 11 subgenera. Three species, Cylindera (Eriodera) albopunctata (Chaudoir 1852), Cicindela viridilabris (Chaudoir 1852) and Neocollyris (Neocollyris) redtenbacheri (Horn 1894) are recorded from Pakistan for the first time.