Cyclic Voltarefractometry of Single TiO Nanoparticles in Large Ensembles in Nonaqueous Electrolyte.

Single nanoparticle (NP) cyclic voltarefractometry (CVR), realized as wide-field surface plasmon resonance microscopy (SPRM) in combination with potential cycling, has been proposed and applied to the in situ study of TiO NPs. Electrochemical activity of TiO is mainly observed outside the electrochemical stability window of water. Therefore, the response of individual anatase (a-TiO) and rutile (r-TiO) NPs adsorbed on a gold layer was studied in 0.

Nucleation, crystal growth, nuclei stability, and polymorph selection in supercooled tolbutamide melt.

Nucleation is an essential step of overall crystallization, yet crystal nuclei are elusive to direct observation due to their small size and transient nature. A method for assessing the nuclei size distribution and growth rate based on selective melting/dissolving was developed recently, making use of the rapid heating/cooling rate available in fast scanning calorimetry. The method was first employed to study the nuclei in the polymer poly-L-lactic acid.

Simplifying perovskite solar cell fabrication for materials testing: how to use unetched substrates with the aid of a three-dimensionally printed cell holder.

This work demonstrates that unetched substrates can be reliably used in perovskite solar cell (PSC) fabrication. Chemical etching and laser patterning of the bottom electrodes are time- and resource-consuming processes. In particular, when testing novel conductive substrate materials, such as metallic or bio-based substrates, etching or patterning could be entirely unfeasible or could require significant process optimization.

Agglomeration compaction promotes corrosion of gold nanoparticles.

Engineered nanoparticles are increasingly being used in various areas of human activity. However, the degradation mechanism of nanobodies in harsh environments is still a puzzle for theory and experiment. We report here the results of optical spectroscopy and nanoparticle tracking analysis, quantifying agglomeration and sizing of 50 nm citrate stabilized gold nanoparticles (GNPs) in HCl solutions containing HO.

STRUGGLE FOR. Italian-Polish-Spanish-Uzbek-Vietnamese Expert Forum Position Paper 2023 for better control of classical modifiable risk factors in clinical practice.

The progress in pharmacotherapy that has been made in recent years, including the introduction of very effective and safe lipid-lowering and antihypertensive drugs, has not yet translated into the expected universal control of blood pressure, lipid disorders and diabetes. In the STRUGGLE FOR Italian- -Polish-Spanish-Uzbek-Vietnamese Expert Forum Position Paper 2023, experts from five countries recounted several points about the paradigms of cardiological and cardiometabolic care for better control of classical modifiable risk factors in the year 2023. It is believed herein, that the need to intensify treatment, actively search for patients with cardiovascular risk factors, especially with arterial hypertension, hypercholesterolemia and diabetes, should go hand in hand with the implementation of the latest therapy, based on single pill combinations including proven, effective antihypertensive, lipid-lowering and antidiabetic molecules, many of which are listed in the present document.

Magnetic and Fluorescent Dual-Labeled Genetically Encoded Targeted Nanoparticles for Malignant Glioma Cell Tracking and Drug Delivery.

Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically incurable disease characterized by rapid growth resistance to classical therapies, with a median patient survival of about 15 months. For decades, a plethora of approaches have been developed to make GBM therapy more precise and improve the diagnosis of this pathology. Targeted delivery mediated by the use of various molecules (monoclonal antibodies, ligands to overexpressed tumor receptors) is one of the promising methods to achieve this goal.

Thermodynamic Properties of 3- and 4-Ethoxyacetanilides between 80 and 480 K.

In this work, we present a comprehensive study of the thermodynamic properties of 3-and 4-ethoxyacetanilides. The heat capacities in crystalline, liquid, and supercooled liquid states from 80 to 475 K were obtained using adiabatic, differential scanning (DSC), and fast scanning (FSC) calorimetries. The fusion enthalpies at were combined from DSC measurement results and the literature data.

Discovery of the novel HLA-B*39:198 allele, a variant of HLA-B*39:01:01, in a Russian individual.

One nucleotide substitution in codon 336 of HLA-B*39:01:01:01 results in the novel allele, HLA- B*39:198.

Characterization of the novel HLA-C*07:402:02 allele detected in a potential hematopoietic stem cell donor.

The novel HLA-C*07:402:02 allele was characterized using next-generation sequencing technology.

Metabolic Markers Associated with Progression of Type 2 Diabetes Induced by High-Fat Diet and Single Low Dose Streptozotocin in Rats.

Science is still searching for readily available, cost-effective biomarkers to assess metabolic disorders occurring before the onset and during the development of type-2 diabetes (T2DM). The aim of the present study was to induce T2DM in rats through a high-fat diet, followed by a single administration of low dose streptozotocin (STZ), and make an assessment of the development of the disease. The rats were divided into two groups-experimental and control-and were monitored for a period of 10 days.

Characterization of Glutathione Dithiophosphates as Long-Acting HS Donors.

Considering the important cytoprotective and signaling roles but relatively narrow therapeutic index of hydrogen sulfide (HS), advanced HS donors are required to achieve a therapeutic effect. In this study, we proposed glutathione dithiophosphates as new combination donors of HS and glutathione. The kinetics of HS formation in dithiophosphate solutions suggested a continuous HS release by the donors, which was higher for the dithiophosphate of reduced glutathione than oxidized glutathione.

Isolation of Mixed Compositions of Cellulose Nanocrystals, Microcrystalline Cellulose, and Lignin Nanoparticles from Wood Pulps.

From a circular economy perspective, one-pot strategies for the isolation of cellulose nanomaterials at a high yield and with multifunctional properties are attractive. Here, the effects of lignin content (bleached vs unbleached softwood kraft pulp) and sulfuric acid concentration on the properties of crystalline lignocellulose isolates and their films are explored. Hydrolysis at 58 wt % sulfuric acid resulted in both cellulose nanocrystals (CNCs) and microcrystalline cellulose at a relatively high yield (>55%), whereas hydrolysis at 64 wt % gave CNCs at a lower yield (<20%).

Identification of ectoparasitic insects among domestic goats in Bulgaria.

Background And Aim: Ectoparasitic entomoses cause serious economic losses to small-scale farmers. Parasites have both direct and indirect impacts on hosts. Domestic goats are a common target of infestation with ectoparasitic insects.

Identification and characterization of the novel HLA-B*39:189 allele by next-generation sequencing.

The novel HLA-B*39:189 allele was characterized using next generation sequencing technology.

Identification of the novel HLA-C*12:349 allele in a potential hematopoietic stem cell donor.

The novel HLA-C*12:349 allele was characterized using next generation sequencing technology.

Synthesis and Functional Characterization of CoFeO-BaTiO Magnetoelectric Nanocomposites for Biomedical Applications.

Nowadays, magnetoelectric nanomaterials are on their way to finding wide applications in biomedicine for various cancer and neurological disease treatment, which is mainly restricted by their relatively high toxicity and complex synthesis. This study for the first time reports novel magnetoelectric nanocomposites of CoFeO-BaTiO series with tuned magnetic phase structures, which were synthesized via a two-step chemical approach in polyol media. The magnetic CoFeO phases with x = 0.

Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines.

Redox-responsive and magnetic nanomaterials are widely used in tumor treatment separately, and while the application of their combined functionalities is perspective, exactly how such synergistic effects can be implemented is still unclear. This report investigates the internalization dynamics of magnetic redox-responsive nanoparticles (MNP-SS) and their cytotoxicity toward PC-3 and 4T1 cell lines. It is shown that MNP-SS synthesized by covalent grafting of polyethylene glycol (PEG) on the magnetic nanoparticle (MNP) surface via SS-bonds lose their colloidal stability and aggregate fully in a solution containing DTT, and partially in conditioned media, whereas the PEGylated MNP (MNP-PEG) without S-S linker control remains stable under the same conditions.

Structure and Magnetic Properties of SrFeInO Compounds for Magnetic Hyperthermia Applications.

In this work, complex studies of the structure and magnetic properties of SrFeInO powders obtained by the mechanochemical and citrate methods were carried out. The solubility of In in strontium hexaferrite SrFe₁₂O₁₉ at 1200 °C was determined. The structure and properties of the powders were studied using X-ray diffraction analysis, Mössbauer spectroscopy and scanning electron microscopy.

Characterization of the novel alleles: HLA-A*31:212, HLA-B*50:01:20 and HLA-C*03:593.

Three novel HLA alleles HLA-A*31:212, HLA-B*50:01:20 and HLA-C*03:593 alleles detected during routine next generation sequencing.

The detection of three novel HLA-A alleles: HLA-A*02:1037, -A*02:1038 and -A*02:1039.

Three novel HLA-A alleles HLA-A*02:1037, -A*02:1038 and -A*02:1039 alleles detected during routine next generation sequencing.

Characterization of the novel HLA-B*35:547 allele detected in a potential hematopoietic stem cell donor.

The novel HLA-B*35:547 allele was characterized using next generation sequencing technology.

Two novel HLA-DQB1 alleles identified in potential hematopoietic stem cell donors: DQB1*03:01:50 and -DQB1*03:453.

HLA-DQB1*03:01:50 and -DQB1*03:453, two novel alleles detected by next generation sequencing.

TIMES TO ACT. Italian-Spanish-Polish-Uzbek Expert Forum Position Paper 2022. Dyslipidemia and arterial hypertension: The two most important and modifiable risk factors in clinical practice.

Hypertension and lipid disorders are two of the main cardiovascular risk factors. Both risk factors - if detected early enough - can be controlled and treated with modern, effective drugs, devoid of significant side effects, available in four countries as different as Italy, Spain, Poland, and Uzbekistan. The aim herein, was to develop this TIMES TO ACT consensus to raise the awareness of the available options of the modern and intensified dyslipidemia and arterial hypertension treatments.