Publications by authors named "Fakhri O Yousef"
Article Synopsis
- - Valsartan (VAL), a phenyl tetrazole derivative, exhibits specific absorption and fluorescence properties, with peaks at 230 nm and 255 nm for absorption, and roughly 346 nm for fluorescence, which shift based on the solvent's H-bonding capability.
- - The fluorescence emission bands of VAL change with pH levels, moving from 425 nm at pH 2 to 375 nm at pH 4, and show decreased fluorescence intensity beyond pH 5 due to the formation of a tetrazole anion.
- - Time-resolved fluorescence measurements and computational methods reveal different excited-state species influenced by pH, with Valsartan adopting a dimer shape in water due to strong intermolecular
The furo[2,3-b]pyridine moiety is an important scaffold for many biologically active compounds, therefore, the spectral data of the derivative 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]pyridin-2-yl) ethenone (FP1) were investigated. Analysis of absorption-pH profile and Förster cycle of FP1 revealed that its excited state is more acidic than its ground state ([Formula: see text] < [Formula: see text]). The main fluorescence emission band of FP1 at 480 nm (in hexane) is shifted to longer wavelengths with increasing polarities of solvents.
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