Publications by authors named "Fakhreddine Maaloum"

Introduction: antimicrobial resistance in gram-negative bacilli is one of the major concerns in public health. We aimed to evaluate gram-negative bacilli epidemiology, antimicrobial profiles, and the resistance´s mechanism for Enterobacteriaceae isolated from specimens of hospitalized patients in wards of University Hospital Center Ibn Rochd of Casablanca, Morocco.

Methods: a prospective study of the patient's specimens, collected from December 2016 to 31 March 2017.

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Background: Streptococcus pneumoniae (S. pneumoniae), remains a major cause of mortality and morbidity worldwide. The objective of this study was to determine the trends of invasive pneumococcal diseases (IPD) in adult and elderly population in Casablanca (Morocco) before and after introduction of pneumococcal conjugate vaccine (PCV) by determining the distribution of pneumococcal serotypes and antibiotic resistance profile of isolated strains.

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Article Synopsis
  • The case discusses a male late preterm newborn who developed respiratory distress shortly after birth, revealing meningitis caused by Serotype 17F pneumonia through vertical transmission from the mother.
  • The newborn underwent treatment with multiple antibiotics, including ceftriaxone and gentamycin, due to the antibiotic resistance of the pneumococcal strain.
  • The report emphasizes that symptoms of neonatal pneumococcal meningitis can be atypical, stressing the importance of awareness in diagnosis and treatment.
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Background: The emergence of carbapenemase-producing Enterobacterales (CPE) is a public health problem, requiring rapid and reliable diagnostic methods. The aim is to compare the new rapid immunochromatographic (IC) test: RESIST-5 O.O.

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Background: Streptococcus pneumoniae serotype 1 remains a leading cause of invasive pneumococcal diseases, even in countries with PCV-10/PCV-13 vaccine implementation. The main objective of this study, which is part of the Pneumococcal African Genome project (PAGe), was to determine the phylogenetic relationships of serotype 1 isolates recovered from children patients in Casablanca (Morocco), compared to these from other African countries; and to investigate the contribution of accessory genes and recombination events to the genetic diversity of this serotype.

Results: The genome average size of the six-pneumococcus serotype 1 from Casablanca was 2,227,119 bp, and the average content of coding sequences was 2113, ranging from 2041 to 2161.

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Article Synopsis
  • Regular surveillance of invasive meningococcal diseases is crucial for identifying antibiotic resistance and new clones of bacteria.
  • An epidemiological study in Casablanca, Morocco, analyzed 245 meningitis isolates from 2010 to 2019, with 93% identified as group B.
  • While 24% of isolates showed reduced susceptibility to penicillin G, none were resistant, and all strains were susceptible to third-generation cephalosporins; genotyping revealed most belonged to clonal complex CC 32.
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Introduction: the laboratory diagnosis of tuberculosis (TB) relies mainly on conventional techniques. However, it either lacks sensitivity or it is time-consuming. This study aims to evaluate the use of real-time polymerase chain reaction (PCR) targeting IS6110 for Mycobacterium tuberculosis (TB) Complex (MTBC) in the routine diagnosis of TB in our laboratory.

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colonizes asymptomatically the human nasopharynx. This pathogen is responsible for sinusitis, otitis media, pneumonia, bacteremia and meningitis. We report the case of a 35-year-old female patient who developed a surgical wound infection by a multi drug resistant serotype 19A after a total coloprotectomy.

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Pneumococcal meningitis is a global scourge. It is a major cause of morbidity and mortality. In Morocco, 13-valent pneumococcal conjugate vaccine (PCV13) was introduced into the National Immunization Program in October 2010 according to the immunization schedule 2 + 1 and replaced by PCV10 in July 2012, according to the same schedule.

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This study aims to determine the prevalence of HIV infection among patients hospitalized for tuberculosis in the Division of Infectious Diseases at the Ibn Rochd University Hospital in Casablanca and factors associated with TB-HIV co-infection. We conducted a cross-sectional retrospective study in November 2016. The database of the Division of Infectious Diseases, Laboratory of Microbiology and Immunology at the Ibn Rochd University Hospital was examined.

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Background And Objectives: bacteremia are grave because of the multi-resistance of the organism to antibiotics. This study aimed to determine the prevalence of isolated from blood cultures and to describe their antibiotic resistance patterns.

Materials And Methods: A retrospective longitudinal study was conducted on blood cultures between 2010 and 2014 from all Ibn Rochd University Hospital intensive care units; it was based on the exploitation of microbiology laboratory database (duplicates were excluded).

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Synopsis of recent research by authors named "Fakhreddine Maaloum"

  • - Fakhreddine Maaloum's recent research focuses on the epidemiology and antimicrobial resistance of various bacterial pathogens, particularly Gram-negative bacilli and Streptococcus pneumoniae, in clinical samples from Morocco, highlighting the prevalence of multidrug-resistant and extensively drug-resistant strains.
  • - His studies also investigate the impact of pneumococcal vaccination on invasive diseases among adults and the elderly, as well as the genetic diversity of Streptococcus pneumoniae strains causing infections in children, contributing to the understanding of vaccine effectiveness and the evolution of resistance.
  • - Additionally, Maaloum has explored rapid diagnostic methods for infections like tuberculosis and the co-infection rates of HIV among tuberculosis patients, indicating a strong emphasis on improving public health responses to infectious diseases through better diagnostics and understanding of pathogen resistance.