Publications by authors named "Fakhar Latif"
Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.
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- Traumatic brain injury (TBI) is linked to serious health issues like venous thromboembolism and higher death rates, making early post-traumatic prophylaxis (PTP) important for patient recovery.
- A systematic review analyzed data from 20 studies with over 87,000 patients, revealing that early PTP significantly cuts the risks of VTE, DVT, PE, and overall mortality compared to later administration.
- The results emphasize the effectiveness of early pharmacologic thromboprophylaxis in improving outcomes for TBI patients, although the timing of administration (within 48 hours) is particularly critical for achieving statistical significance.
Article Synopsis
- The study investigated the link between cancer risks and the use of SGLT2 inhibitors in patients with Type 2 diabetes by following established research guidelines and analyzing data from 19 randomized controlled trials (RCTs).
- The findings indicated a potential increase in certain types of cancers, including reproductive and skin cancers, associated with SGLT2i use, but these results were not statistically significant.
- The study calls for caution regarding SGLT2i prescriptions for diabetic patients and emphasizes the need for further research to better understand the cancer risk connections.
Demographics and mortality trends of valvular heart disease in older adults in the United States: Insights from CDC-wonder database 1999-2019.
Int J Cardiol Cardiovasc Risk Prev
September 2024
Article Synopsis
- Valvular heart disease (VHD) encompasses various heart valve issues and has significantly impacted mortality rates among older adults in the U.S. from 1999 to 2019.
- A study using CDC data found a general decline in mortality rates associated with VHD until 2007, followed by stability and then a significant decrease until 2019, with higher rates in men and disparities across different racial and geographic groups.
- The research revealed notable differences in age-adjusted mortality rates (AAMRs) by race, region, and type of valvular disease, with non-metropolitan areas and specific states showing higher mortality rates.
Introduction: This meta-analysis seeks to evaluate the efficacy of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) in individuals with chronic kidney disease (CKD), end-stage renal disease (ESRD), and undergoing hemodialysis (HD) who also have atrial fibrillation (AF).
Evidence Acquisition: A comprehensive search of MEDLINE, clinicaltrials.gov, EMBASE, and Cochrane Database for relevant studies reporting the usefulness of OAC therapy for CKD, ESRD, and HD patients with AF was conducted from its inception until 1 May 2023.
Background: Dementia is a recognized complication of atrial fibrillation (AF). Oral anticoagulant (OAC) therapy can potentially be protective against this complication.
Methods: A comprehensive search of MEDLINE and Embase for comparative observational studies reporting the efficacy of OAC therapy for the incidence of dementia in patients with AF was conducted from its inception until March 2023.
Introduction: Cariprazine is an orally active dopamine D3-preferring D3/D2 receptor and serotonin 5-HT1A receptor partial agonist, being considered as a treatment for refractory MDD. Therefore, we aim to perform the first meta-analysis of current literature, to collate changes in depression from baseline and assess tolerability of adjunctive cariprazine in MDD populace.
Methods: PubMed, Embase, Google Scholar, ClinicalTrials.
Tricuspid regurgitation (TR) is traditionally treated surgically, but isolated transcatheter tricuspid valve repair (ITTVR) offers a less invasive option. This study conducts a meta-analysis and systematic review to evaluate ITTVR outcomes in patients with TR. Database searches until March 2023 identified studies assessing ITTVR safety and efficacy in moderate/severe TR patients.
View Article and Find Full Text PDFDementia and non-alcoholic fatty liver disease - An unprecedented relationship.
Ann Med Surg (Lond)
September 2022