Publications by authors named "Faiz Sher"
The relationship between diffusion anisotropy and time of onset after stroke.
J Cereb Blood Flow Metab
November 2006
Diffusion anisotropy changes in stroke lesions less than 24 h after onset have been reported to be elevated, decreased, or both. To address these mixed findings, we sought to characterize temporal changes of diffusion anisotropy by analyzing anatomically distinct ischemic white matter (WM) regions at 3 time phases within the first 34 h of ischemic stroke onset in 26 stroke patients (2 to 5 h, N=7; 7 to 14 h, N=11; 18 to 34 h, N=8). Mean diffusivity (Trace/3 apparent diffusion coefficient (ADC)), fractional anisotropy (FA), and T2-weighted signal intensity were measured for major and subcortical WM in lesions defined by a >or=30% drop in Trace/3 ADC.
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- Endothelial progenitor cells (EPCs) are crucial for repairing blood vessels after ischemic events, but little is known about their role in cerebrovascular disease.
- In a study, EPC counts were significantly lower in stroke patients (both acute and stable) compared to healthy controls, indicating a potential link to cerebrovascular issues.
- The study also found a correlation between EPC levels and the Framingham coronary risk score, suggesting that low EPC counts could contribute to the development of cerebrovascular diseases.