Publications by authors named "Faiyaz Hussain Madni Vaid"
Ascorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Article Synopsis
- Photodegradation of drug substances can produce both known and unknown products that interfere with analytical results due to absorption at certain wavelengths.
- The study focuses on improving the accuracy of measurements for methylcobalamin (MC) and hydroxocobalamin by applying linear and non-linear methods to correct for irrelevant absorbances during photolytic degradation involving ascorbic acid (AH).
- Methylcobalamin shows first-order degradation kinetics, with the degradation rate being pH-dependent; it peaks at pH 5.0 when in the presence of ascorbic acid, whereas degradation slows down in more alkaline conditions.
The effect of caffeine complexation with riboflavin on the kinetics of riboflavin photolysis in the pH range 2.0-10.5 has been studied.
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