Antimalarial Efficacy and Safety of (L.) Link Root Extract in -Infected BALB/c Mice.

Background: Emergence of resistance to antimalarial drugs presents a major drawback in efforts to control malaria. To address this problem, there is an urgent and continuous need for the development of new and effective antimalarial agents. (L.

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice.

Background: Senna occidentalis (L.) Link has been used worldwide in traditional treatment of many diseases and conditions including snakebite. In Kenya, a decoction from the plant roots taken orally, is used as a cure for malaria.

Immunization of mice with soluble lysate of interferon gamma expressing ANKA induces high IFN-γ production.

Background: Efforts in search of lasting malaria vaccine have led to the development of transgenic rodent malaria parasites. As a result, wild type ANKA (WTPbA) has recently been transformed to express mouse interferon gamma (mIFN-γ). The immunomodulatory effect of this transgenic parasite on WTPbA infection has been demonstrated.

Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infection.

Background: Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical challenges. This study set out to bridge this gap by determining the outcome of PM in non-immune baboons in order to develop a non-human primate model for the disease.