Publications by authors named "Faith Cheong"
Cell Genom
September 2024
Article Synopsis
- * This study combined short- and long-read scRNA-seq to create a detailed transcriptomic atlas of CRC, revealing 394 dysregulated transcript structures and identifying specific genes and isoforms linked to different tumor cell subpopulations with varied prognoses.
- * An algorithm was developed to link novel peptides from these recurrent tumor-specific transcripts with mass spectrometry data, leading to the discovery of recurring neoepitopes that could potentially inform the creation of new cancer vaccines.
Int J Mol Sci
February 2023
Article Synopsis
- Before next-generation sequencing, AML research focused on protein-coding genes, but new RNA sequencing technologies reveal that about 97.5% of the human genome is made up of non-coding RNAs (ncRNAs).
- Recent findings have highlighted the importance of various types of non-coding RNAs, especially circular RNAs (circRNAs) and non-coding untranslated regions (UTRs) in the development of AML.
- The review discusses the roles of circRNAs and 3'UTRs in AML, their potential as biomarkers for diagnosis and treatment response, and their promise as targets for innovative RNA-based therapies.
