Publications by authors named "Faisal Wahid"
Article Synopsis
- The study aimed to compare respiratory complications during extubation in two positions: conventional recovery position versus a modified recovery position with a 10-degree left tilt and head-down.
- Conducted at Combined Military Hospital in Pakistan from April 2022 to March 2023, 200 elective nose and throat surgery patients were divided into two groups, excluding those with certain respiratory conditions or multiple intubation attempts.
- Results showed significantly fewer airway complications in the modified recovery position group (6%) compared to the conventional group (18%), suggesting that the modified position is safer for extubation.
Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play critical roles in B cell development and antibody production. Primary antibody deficiencies in humans might therefore reflect a deficit in MDCs and/or PDCs. We tested this hypothesis by measuring dendritic cell (DC) subset numbers in patients with common variable immunodeficiency (CVID), X-linked agammaglobulinaemia (XLA) and specific polysaccharide antibody deficiency (SPAD).
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- Multiple sclerosis (MS) involves CD4 T cells reacting to myelin, with a focus on the role of HLA-DR15-restricted T cells and the identification of triggering epitopes.* -
- This study utilized humanized transgenic mice expressing HLA-DR15 and related T cell receptors, which spontaneously developed MS-like symptoms, including paralysis and nerve damage.* -
- The findings indicate that T cell responses in these mice resemble those observed in human MS patients, providing a valuable model for understanding disease mechanisms and testing new peptide immunotherapies.*
While EAE has been an invaluable model for the immunopathogenesis of multiple sclerosis, it has sometimes been difficult to bridge the gap between findings and therapies in the rodent models and the cellular and molecular interactions that can be studied in the human disease. Humanized transgenic models offer a means of achieving this, through the expression of disease-implicated HLA class II molecules, co-expressed with a cognate HLA-class II-restricted, myelin-specific TCR derived from a human T cell clone implicated in disease. We have generated such a transgenic line, called line 8, that co-expresses a high level of HLA-DR15 and a human TCR specific for HLA-DR15/MBP 85-99.
View Article and Find Full Text PDFThe gene encoding streptococcal mitogenic exotoxin Z (SMEZ) was disrupted in Streptococcus pyogenes. Despite the presence of other superantigen genes, mitogenic responses in human and murine HLA-DQ transgenic cells were abrogated when cells were stimulated with supernatant from the smez(-) mutant compared with the parent strain. Remarkably, disruption of smez led to a complete inability to elicit cytokine production (TNF-alpha, lymphotoxin-alpha, IFN-gamma, IL-1 and -8) from human cells, when cocultured with streptococcal supernatants.
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