Dystrophic epidermolysis bullosa phenotypes in a large consanguineous Tunisian family.

Background: Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous blistering disorder of the skin and mucous membranes. DEB is caused by mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils. On the basis of the mode of inheritance and the clinical manifestations, DEB is classified into two major subtypes: one dominant (DDEB) and one recessive (RDEB).

Penile shaft involvement in pityriasis versicolor.

The Malassezia yeasts are among the normal human cutaneous flora in adults. They are also reported as part of the microflora of male genital region, mostly in uncircumcised males. The prevalence of Malassezia yeast colonization on the glans penis of circumcised males is discussed in multiple studies.

Haplotypic classification of dystrophic epidermolysis bullosa in Tunisian consanguineous families: implication for diagnosis.

Dystrophic epidermolysis bullosa (DEB) is a rare genodermatosis caused by mutations in the type VII collagen gene COL7A1. Clinical diagnosis of DEB should be confirmed by histopathological and electron microscopy analysis, which is not always accessible. We report here a genetic investigation of DEB consanguineous families in Tunisia.

[Porokeratosis. A study about 6 cases].

Background: Porokeratoses (PK) represent a less common group of dermatoses that are acquired or hereditary, of unknown pathogenesis, characterized by keratinization disorder. Different clinical forms have been identified and the most frequent are the Mibelli's porokeratosis (MP) and the Disseminated Superficial Actinic Prokeratosis (DSAP).

Aim: In this retrospective study, we analysed the observations of PK collected in the Dermatology Department of La Rabta Hospital over a 16-year period.

[Cryosurgery for nose basal cell carcinoma. Series of 17 tumors].

Unlabelled: Basal cell carcinoma (BCC) is the most common malignant tumour of the skin frequently located on the head and chiefly on the nose. Cryosurgery is one of the methods to treat BCC.

Object: To determine the efficacy of cryosurgery of 17 BCC of the nose in terms of recurrence rates and cosmetic results.

Erysipelas of the left upper limb occurring after elbow dislocation.

Background: Erysipelas is an acute infection occurring chiefly in the lower limbs, rarely in the upper limbs.

Observation: A 45-year-old patient suffering from Charcot-Marie-Tooth disease with neuropathy of the limbs, presented with fever and a 24-hour history of a well-circumscribed inflammatory and infiltrated plaque of the left arm. Erysipelas was diagnosed and intravenous penicillin was administered leading to regression of the inflammatory signs, however edema persisted in the inner part of the left elbow.

[Eccrine poroma of the scalp: A study of three cases].

The eccrine poroma is a rare benign sudoral tumour, which creates a fleshy formation. The diagnosis is made according to the anatomopathological study. The usual site is the sol, but in rare cases, other sites have also been reported.

[Pseudoxanthoma elasticum: a report of 11 cases].

Introduction: Pseudoxanthoma elasticum (PXE) is an inherited disorder of elastic tissue with many systemic manifestations

Patients And Methods: We performed a retrospective study from all the patients diagnosed with PXE at the department of dermatology of La Rabta hospital of Tunis, between 1986 and 2003.

Results: During the observation period, we identified 11 patients with PXE, 5 males and 6 females with a mean age of 28 years (10-47 years). Family history was found in 5 patients.

[Nasosinusal sarcoidosis: 2 cases. A report of 2 cases].

Introduction: Nasosinusal sarcoidosis is a rare non caseating granulomatous disease. It may be inaugural, isolated or associated with multisystemic sarcoidosis.

Material And Methods: [corrected] We report two cases of nasosinusal sarcoidosis associated to multisystemic sarcoidosis.

Discoid lupus erythematosus in an infant.

Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 15-month-old female infant who presented with erythematous telangectatic lesions and photosensitivity involving the sun-exposed areas. Histological examination confirmed the diagnosis of DLE.

[Childhood linear psoriasis].

Linear distribution of psoriasis is rare. This presentation offers to physicians some diagnostic difficulty, especially in the absence of a history of pre-existing psoriasis or in the presence of any other linear dermatosis. In this study, we report cases of 3 girls, ages 4 yr, 5 yr and 10 yr, admitted to our dermatology department.

Erythroderma in adults: a report of 80 cases.

Background: Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979.

[Erythema elevatum diutinum. A clinicopathologic study of 5 cases].

Erythema elevatum diutinum is a rare condition of unknown etiology listed with cutaneous vasculitis or neutrophilic diseases. Medical records and histopathologic slides of 5 patients with erythema elevatum diutinum were studied to better understand the disease. Lesions were clinically characteristic.

[Granuloma annulare: apropos of 18 cases].

Granuloma annulare is a benign skin disorder which cause is unknown. The aim of this work is to report the results of a retrospective study dealing with 18 cases of granuloma annulare carried in the dermatology department of la Rabta hospital over a nine year period. We describe 3 clinical forms: localized granuloma annulare: 9 cases, generalized granuloma anulare: 7 cases and deep granuloma annulare: 2 cases.

Childhood discoid lupus erythematosus: a Tunisian retrospective study of 16 cases.

Discoid lupus erythematosus (DLE) is uncommon in children. The clinical features of childhood DLE are similar to those of adult DLE in presentation and chronic course. However, children have a particularly high level of transition to systemic disease.