Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Rats.

Goniothalamin (GTN) is an isolated compound from several plants of the genus , and its anticancer effect against several cancers was reported. However, there is no scientific data about effects of its higher doses on internal organs. Accordingly, this study aimed to evaluate the acute and subacute effects of higher doses of GTN on the hematology, biochemistry, and histology of selected internal organs of male rats.

Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts.

Objectives: In vivo study was performed to determine the chemopreventive efficacy of the DC resin methanol extract on a 4-nitroquinoline-1-oxide (4NQO) oral cancer animal model.

Materials And Methods: This study involves administration of 4NQO solution for 8 weeks alone (cancer induction) or with Dracaena cinnabari (DC) extract at 100, 500, and 1000 mg/kg. DC extract administration started 1 week before exposure until 1 week after the carcinogen exposure was stopped.