Synthesis, radiolabeling and evaluation of [Tc][Tc-HYNIC/EDDA]-Met(O) as a early agent for amino acid metabolic imaging in C6 glioblastoma tumor.

Amino acid metabolism is recognized as a target for medical imaging due to its increase in malignant cells. Several radiotracers with primary achievement and possible subsequent chances have been designed and tested to image amino acid metabolism. Here, we report a new amino acid conjugate, with the purpose of extending [Tc][Tc-HYNIC/EDDA]-Met(O) for single photon emission tomography (SPECT) imaging.