Publications by authors named "Fahim U Khan"

Additives leached from tire particles (TPs) after entering the marine environment inevitably interact with marine life. Marine heatwaves (MHWs) would play a more destructive role than ocean warming during the interaction of pollutants and marine life. To evaluate the potential risks of TPs leachate under MHWs, the physiological and nutrient metabolic endpoints of microalgae were observed for 7 days while being exposed to TPs leachate at current or predicted concentrations under MHWs.

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Antimicrobial resistance is one of the principal global health problems, and it is imperative to develop new drugs to reduce the spread of antimicrobial-resistant microorganisms. The flower extract of Butea monosperma and the root extract of Glycyrrhiza glabra are used to green synthesize zinc oxide nanoparticles (ZnO-NPs) using zinc acetate dihydrate. We characterized the biosynthesized ZnO-NPs using various techniques.

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Due to continuous increase in marine plastic waste, microplastics are ubiquitous in the marine environment. However, there are few studies on the harmful effects caused by microplastics with different particle sizes, and the interaction between particle size and concentration requires further investigation. This study explored the differences in physiological and biochemical responses, photosynthesis and oxidative stress damage of the microalga Isochrysis galbana exposed to three different particle size microplastics.

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The Pteridaceae family, known for its taxonomic complexity, presents challenges in identification due to high variability among its species. This study investigates the spore morphology employing both SEM and LM techniques in 10 Pteridaceae taxa phytogeographicaly Sino-Himalayan, Malesian, and European elements in Pakistan. The taxa include Adiantum capillus-veneris, A.

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Rayon microfibers, micro-sized semi-synthetic polymers derived from cellulose, have been frequently detected and reported as "micropollutants" in marine environments. However, there has been limited research on their ecotoxicity and combined effects with persistent organic pollutants (POPs). To address these knowledge gaps, thick-shell mussels (Mytilus coruscus) were exposed to rayon microfibers at 1000 pieces/L, along with polychlorinated biphenyls (PCBs) at 100 and 1000 ng/L for 14 days, followed by a 7-day recovery period.

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Anthropogenic noise has significantly increased due to human activities, posing a threat to the health and survival of marine organisms. However, current studies have often emphasized its effects on the physiological aspects of marine organisms, while ignored the relationship between the neuroendocrine system and behavior. This study aimed to evaluate the righting behavior and relevant physiological functions of the central nervous system (CNS) in sea slug (Onchidium reevesii) exposed to low-frequency noise and subsequent noise removal.

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Micro-/nano-plastic particles (MNPs) are present in the ocean with potential detrimental impacts on marine ecosystems. Bivalves are often used as marine bioindicators and are ideal to evaluate the threat posed by various-sized MNPs. We exposed the mussel Mytilus coruscus to MNPs with different particle sizes (70 and 500 nm, 5, 10 and 100 μm) for 3, 72 h and 30 days.

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Industrial development not only triggers heavy metal pollution but also introduces a less easily discernible disturbance: low-frequency noise pollution. Low-frequency noise can disrupt wildlife behavior, potentially exerting complex effects through interacting with heavy metals. Nevertheless, the cumulative impacts of low-frequency noise and cadmium (Cd) pollution on marine organisms remain largely unexplored.

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Excessive use of plastics in daily life is causing plastic pollution in aquatic environment and threatening the aquatic life. Therefore, research on the plastic pollution in aquatic environment is crucial to understand its impact and develop effective solution for safeguarding aquatic life and ecosystem. The current study investigated the effects of water borne polystyrene nanoparticles (PS-NPs) on hemato-immunological indices, serum metabolic enzymes, gills, and liver antioxidant parameters, plasma cortisol level and histopathological changes in liver and gill tissues of the widely distributed fish Hypophthalmichthys molitrix.

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Considering the wide application of nanoparticles in various fields of life and growing concern regarding their toxic effects, the present study was designed with the aim to evaluate the potential risks of using copper sulfate nanoparticles (CuSO-NPs) in comparison to bulk form. Nanoparticles of CuSO, having mean size of 73 nm were prepared by ball milling method, and fingerlings of Labeo rohita were exposed to two levels, 20 and 100 μg L of CuSO in both bulk and nano forms for 28 days and their comparative effects on the metallothioneins (MTs), heat shock proteins 70 (HSP 70), lipid profile, cholesterol (CHOL) and triglyceraldehyde (TG) levels, activities of some metabolic enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) Akaline phosphatase (ALP), and genes expressions of HSP-70, TNF-α and IL1-ß were investigated. CuSO showed the concentration and particle type dependent effects.

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Despite being widely distributed in Asia, Carcinoscorpius rotundicauda is often overlooked and, its population status remains unclear. Moreover, it is threatened by illegal harvesting and degradation of mangrove ecosystems. Protecting its habitat is essential for population and biodiversity conservation, as mangroves provide nursery grounds and food supply for C.

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Article Synopsis
  • Pollution from micro- and nano-plastics (MNPs) mixed with organic pollutants like phenanthrene (Phe) significantly threatens coastal marine ecosystems, particularly the immune health of thick-shell mussels.
  • The study revealed that mussel immune cells (hemocytes) are more affected by oxidative stress than gills, exhibiting high mortality, increased reactive oxygen species (ROS), and imbalances in antioxidant enzyme activity when exposed to these pollutants.
  • The combined effects of MNPs and Phe were found to be either additive or antagonistic, indicating that MNPs might not worsen, and sometimes lessen, the toxicity of Phe, emphasizing the complexity of pollutant interactions in marine organisms.
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Microplastics (MPs) are a widespread environmental problem posing ecological risks in the ocean. We investigated the abundance, spatial distribution, characteristics and ecological risks of MPs in surface seawater, sediments and organisms in Yueqing Bay, China. MPs were detected in both environmental media and organisms.

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Article Synopsis
  • The experiment investigated the genetic potential of 93 advanced bread wheat genotypes for yield and resistance to stripe rust across three locations during the 2018-19 crop season.
  • Significant differences were observed among the genotypes for various yield-related traits, with certain genotypes displaying desirable characteristics like high tiller count and grain weight.
  • Some lines showed effective resistance to stripe rust without known resistance genes, indicating the presence of new resistance genes, particularly with genotypes KT-072, KT-07, KT-10, and KT-62 demonstrating high yields and low infection coefficients.
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Background: Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of death worldwide, is characterized by airflow limitation that can be due to abnormalities in the airway and/or alveoli. Genetic diagnosis at an early stage can be a key factor in the provision of accurate and timely treatment. Single Nucleotide polymorphisms (SNPs) are an important tool to study genetic association/ predisposition of the disease and have great potential to be diagnostic markers for early diagnosis of disease.

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Drought is an extreme climatic event that mostly occurs as a result of low rainfall, which leads to lack of water in various agro-ecological conditions of Pakistan. The condition could be further exacerbated by the prevailing dry weather. Therefore, accurate, timely, and efficient drought monitoring is crucial to ensure that its adverse effects are mitigated.

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In South Asia, annual land use and land cover (LULC) is a severe issue in the field of earth science because it affects regional climate, global warming, and human activities. Therefore, it is vitally essential to obtain correct information on the LULC in the South Asia regions. LULC annual map covering the entire period is the primary dataset for climatological research.

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Ocean acidification has become a major ecological and environmental problem in the world, whereas the impact mechanism of ocean acidification in marine bivalves is not fully understood. Cellular energy allocation (CEA) approach and high-coverage metabolomic techniques were used to investigate the acidification effects on the energy metabolism of mussels. The thick shell mussels Mytilus coruscus were exposed to seawater pH 8.

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Backgrounds: The BRASSINAZOLE-RESISTANT (BZR) family of transcription factors affects a variety of developmental and physiological processes and plays a key role in multiple stress-resistance functions in plants. However, the evolutionary relationship and individual expression patterns of the BZR genes are unknown in various crop plants.

Methods And Results: In this study, we performed a genome-wide analysis of the BZR genes family in wheat and rice.

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Background: Linezolid (Oxazolidinones) is commonly used against a variety of Gram-positive infections, especially methicillin-resistant Staphylococcus aureus (MRSA). The emerging resistance to linezolid curtail the treatment of infections caused by MRSA and other Gram-positive bacteria. Presence of cfr gene plays a crucial role in Linezolid resistance.

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Drought is a complex hazard caused by the disruption of rainwater balance, and it always has an impact on ecological, farming and socio-economic. In order to protect farming land in Pakistan, effective and timely drought monitoring is extremely essential. Therefore, a regular drought monitoring is required to study drought severity, its duration and spread, to ensure effective planning and to help reduce their possible adverse impacts.

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Metallic nanoparticles are gaining importance in various fields of life due to their large surface area to volume ratio. However, metallic nanoparticles pose different toxic effects on fish when they appear with different shapes and compositions in water. Herein the present study was designed to evaluate the median (LC) and sub-lethal (1/10th of LC) concentrations of Ag-Green NPs, 700 μg/L for Ag-Chem NPs, and 50 μg/L for AgO-Chem NPs were confirmed in Hypophthalmichthys molitrix.

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Background: Strigolactones (SLs) play a key role in modulating plant root growth, shoot branching, and plant-symbiont interaction. However, despite their significance, the components of SL biosynthesis and signaling in soybean and their role in soybean-rhizobia interaction is unknown.

Methods: In this study, we identified and functionally characterized the from soybean.

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Background: Strigolactones (SLs) are newly identified hormones and their biosynthesis is stimulated under phosphate deprivation and accomplished by the action of several enzymes, including the beta-carotene isomerase DWARF27 (D27). Expression of D27 is well renowned to respond to phosphate insufficiency. However, the identification and functional analysis of the carotenoid isomerase D27 genes are not elucidated in soybean.

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Improving the bioavailability of a drug at the ocular surface presents a profound challenge. Due to ocular physiological barriers, conventional eye drops exhibit poor bioavailability of drugs. Sustained-release nanoparticles may improve the residence time and hence increase absorption of the drug from the corneal surface.

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