Clinical outcomes following tricuspid transcatheter edge-to-edge repair with PASCAL: A meta-analysis.

Background: Patients with severe tricuspid regurgitation (TR) exhibit high morbidity and mortality. Tricuspid transcatheter edge-to-edge repair (T-TEER) is a rapidly evolving strategy to address the unmet clinical need of severe TR therapies.

Objective: Organize the current body of evidence on outcomes following use of the PASCAL (Edwards Lifesciences) system for T-TEER.

Association between ibrutinib treatment and hypertension.

Background: Ibrutinib is a tyrosine kinase inhibitor most commonly associated with atrial fibrillation. However, additional cardiotoxicities have been identified, including accelerated hypertension. The incidence and risk factors of new or worsening hypertension following ibrutinib treatment are not as well known.