A review of the potential use of melatonin in cancer treatment: Data analysis from Clinicaltrials.gov.

Background: Melatonin's antioxidative and immune effects suggest potential in cancer therapy. This review assesses related clinical trials on ClinicalTrials.gov.

Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.

We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved.

An overview of traditional smoking cessation interventions and E-cigarettes.

Many people still struggle with quitting smoking despite available treatment options, making it one of the most significant public health challenges that our society faces. The use of electronic cigarettes (E-cigarettes) has become increasingly popular among people who are seeking to quit smoking. The objective of this review paper is to present a comprehensive analysis of the mechanisms, several types, and impact of E-cigarettes, along with supporting evidence indicating their efficacy in aiding smokers to quit tobacco usage.

Perceptions and Behaviors Regarding Early Screening and Breast-Related Complaints Among Saudi Women.

Background Breast cancer (BC) is a global public health issue, contributing to a significant death toll among women. Breast cancer is the most common type among Saudi women, accounting for over a quarter of all new cancer cases. The current approaches for detecting BC include mammography, clinical breast exams, and breast self-examination (BSE).

An integrated remote sensing, petrology, and field geology analyses for Neoproterozoic basement rocks in some parts of the southern Egyptian-Nubian Shield.

The main objective of this study was to use deep learning, and convolutional neural networks (CNN), integrated with field geology to identify distinct lithological units. The Samadia-Tunduba region of the South Eastern Desert of Egypt was mapped geologically for the first time thanks to the use of processed developed CNN algorithms using Landsat 9 OLI-2, which were further enhanced by geological fieldwork, spectral measurements of field samples, and petrographic examination. According to previously published papers, a significant difference was observed in the distribution of rocks and their boundaries, as well as the previously published geological maps that were not accurately compatible with the nature of the area.

Assessment of groundwater quality in arid regions utilizing principal component analysis, GIS, and machine learning techniques.

Assessing water quality in arid regions is vital due to scarce resources, impacting health and sustainable management.This study examines groundwater quality in Assuit Governorate, Egypt, using Principal Component Analysis, GIS, and Machine Learning Techniques. Data from 217 wells across 12 parameters were analyzed, including TDS, EC, Cl, Fe, Ca, Mg, Na, SO, Mn, HCO, K, and pH.

Understanding migraine in Saudi society: An assessment of public knowledge and attitudes: A cross-sectional study.

Objective: This study aims to assess the knowledge and perceptions of the public toward migraine in Saudi Arabia.

Methods: This cross-sectional survey assessed the knowledge and perceptions of migraine among Saudi Arabian individuals. The study was conducted over three months in 2023 (1st of June 2023 to 31st of August 2023) using a prevalidated online questionnaire divided into four sections.

Topical oxygen therapy as a novel strategy to promote wound healing and control the bacteria in implantology, oral surgery and periodontology: A review.

Globally, oral infections and inflammatory lesions persist as substantial public health concerns, necessitating the introduction of novel oral treatment protocols. Oral diseases are linked to various causative factors, with dental plaque/biofilm resulting from inadequate hygiene practices playing a predominant role. The strategic implementation of novel topical therapies holds promise for effectively controlling the biofilms, addressing oral infections and promoting enhanced oral wound healing.

Targeting inflammation in glioblastoma: An updated review from pathophysiology to novel therapeutic approaches.

Glioblastoma (GBM) is a highly aggressive primary malignant brain tumor with a dismal prognosis despite current treatment strategies. Inflammation plays an essential role in GBM pathophysiology, contributing to tumor growth, invasion, immunosuppression, and angiogenesis. As a result, pharmacological intervention with anti-inflammatory drugs has been used as a potential approach for the management of GBM.

Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats.

Background: Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence. Studies have shown that melatonin could be a potential modulator to reduce tramadol addiction.

Translation, cross-cultural adaptation, and psychometric properties of the Arabic version of the MedRisk instrument for measuring patient satisfaction with physical therapy care.

Purpose: This study aimed to translate, cross-culturally adapt, and validate the MedRisk Instrument for Measuring Patient Satisfaction with Physical Therapy Care into Arabic (MRPS-Ar).

Materials And Methods: The 20-Item MRPS was translated and cross-culturally adapted into Arabic following international guidelines. Patients ( = 229) with musculoskeletal conditions who received physical therapy care completed the MRPS-Ar and global rating of change scale.

Geochemical characteristics, hazards impact assessment and radiogenic heat production of the alkaline rocks.

This study primarily investigates the natural radioactivity level in alkaline rocks collected from the Wadi El-Dib ring complex (WDRC) in North Eastern Desert of Egypt, and assesses potential health risks associated with their use as decorative building materials. The work was accomplished using a high-purity germanium detector as well as ICP-MS and ICP-AES techniques. The WDRC composed essentially of trachyte, quartz syenite, granite and syenite.

The natural anticoagulant protein S; hemostatic functions and deficiency.

Protein S (PS) is a vital endogenous anticoagulant. It plays a crucial role in regulating coagulation by acting as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. Additionally, it possesses direct anticoagulant properties by impeding the intrinsic tenase and prothrombinase complexes.

Mapping coastal groundwater potential zones using remote sensing based AHP model in Al Qunfudhah region along Red Sea, Saudi Arabia.

Due to the increases in agriculture and industry sector as well as high population, lack of water is becoming a major problem in the Middle East especially in arid regions. Saudi Arabia needs more groundwater research and explorations because of its higher water use and no source of freshwater. Assessing groundwater zonation in semi-arid locations is essential due to the significant degree of variation in groundwater depth, aquifer features, topographical characteristics, and insufficient precipitation.

Prediction of weighted arithmetic water quality index for urban water quality using ensemble machine learning model.

Urban water quality index (WQI) is an important factor for assessment quality of groundwater in the urban and rural area. In this research, the Weighted Arithmetic Water Quality Index (WA-WQI) was estimated for understanding the groundwater quality. Four machine learning (ML) models were developed including artificial neural network (ANN), support vector machine (SVM), random forest (RF), and extreme gradient boosting (XG-Boost) in addition to multiple linear regression (MLR) for WA-WQI prediction at the Ujjain city of Madhya Pradesh in India.

Impact of online learning on physical activity during COVID-19 lockdown period among female undergraduate students in Saudi Arabia: a cross-sectional study.

Background: During early 2020, because of the COVID-19 pandemic and related lockdown, most education systems-including universities-shifted from face-to-face classes to online learning. In Saudi Arabia, this might have contributed to a decreased level of physical activity (PA) and a concurrent increase in sedentary behaviour among young adults. This study aimed to investigate the impact of online learning on PA during the COVID-19 lockdown period among female undergraduate students in Saudi Arabia.

Use of over-the-counter mouthwashes as an additional measure in individual oral prophylaxis on adults with plaque-induced gingivitis: a double-blind, parallel, randomized controlled trial.

Background: Plaque-induced gingivitis is a chronic inflammatory condition characterized by complete reversibility of tissue damage once the periodontal biofilm has been disorganised. The aim of this study was to evaluate the efficacy of two commercially available mouthwashes (MWs) versus a chlorhexidine (CHX) 0.12% MW in reducing gingival bleeding (GB) in adults with plaque-induced gingivitis.

Self-Reported Moderate-to-Vigorous Physical Activity: Its Association with Health-Related Quality of Life in a Large Cohort of People with Chronic Diseases.

The aim of this study was to investigate the dose-response relationship between physical activity and health-related quality of life (HRQoL) in a large population-based sample of people with chronic disease. We analysed the data of 29,271 adults (15,315 women) who were diagnosed with chronic diseases and participated in the Welsh Health Survey (Wales, UK; data collection 2011-2015). Participants were classified, based on their weekly minutes of moderate-to-vigorous physical activity (MVPA), into four groups as follows: inactive (no MVPA), insufficiently active (<150 min/week), sufficiently active (≥150-<300), and very active (≥300).

Hydrochemical Assessment of Groundwater from the Harrat Khyber Flood Basalts, Northwest Saudi Arabia.

The present study was carried out in the Harrat Khyber region of the Madinah province in Western Saudi Arabia. The objective of the study was to determine the main factors affecting groundwater chemistry and assess the impact of groundwater quality on human health with respect to nitrate, fluoride, and heavy metals (arsenic, chromium, copper, nickel, selenium, and zinc). Hydrochemical data for 70 groundwater samples from dug wells and bore wells from Harrat Khyber were interpreted to achieve the research objective.

Saudi Adults' Understanding and Views of Weight Management Practices and Obesity.

Background And Objective: The rising prevalence of overweight and obesity presents a significant global challenge. This study aimed to investigate the understanding and views of weight management practices and obesity among Saudi adults.

Methodology: A cross-sectional online survey was conducted from October 2022 to January 2023 among adults residing in Saudi Arabia.

The impact of Resolvin E1 on bone regeneration in critical-sized calvarial defects of rat model-A gene expression and micro-CT analysis.

Objective: To investigate, in vivo, the effect of local application of Resolvin E1 (RvE1) on the bone regeneration of critical-size defects (CSDs) in Wistar rats utilizing gene expression and micro-computed tomographic (micro-CT) analysis.

Background: The inflammation-resolving actions of RvE1 are well established. The molecular mechanism of its bone-regenerative actions has been of significant interest in recent years; however, there is limited information regarding the same.

Influence of gingival display on smile attractiveness assessed by Saudi Arabian laypersons and dental professionals.

This study was undertaken to evaluate the influence of changes in the gingival display of the maxillary teeth on smile attractiveness assessed by Saudi Arabian dental professionals and laypeople. A total of 138 dental professional and 182 laypeople rated the attractiveness of male and female smiles in a computerized survey. A smiling photograph of a male and a female dental students were selected and digitally manipulated to create changes the amount of gingival display from 4 mm of gingival display to 4mm of gingival covered by the upper lip in 1 mm increments.

Amphetamines in child medicine: a review of ClinicalTrials.gov.

Globally, the use of amphetamines as therapeutic agents in pediatric medicine is a crucial area of concern, especially given the population's vulnerability. On 6 August 2023, a search was conducted on ClinicalTrials.gov using "amphetamine" as the keyword.