Publications by authors named "Fahad Al Saif"

Article Synopsis
  • The introduction of biological treatments has significantly improved the management of moderate-to-severe psoriasis, with established efficacy from clinical trials, but optimal monitoring intervals during treatment remain unclear.
  • This study aimed to analyze laboratory data from patients on biological therapy to assess the necessity for lab investigations and to identify any adverse events.
  • Results indicated that most significant laboratory abnormalities occurred at baseline and during specific follow-up intervals, with infliximab users showing the highest rate of abnormalities, while dermatology patients had fewer issues compared to gastroenterology and rheumatology patients.
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Adalimumab is a fully human, recombinant, IgG1 monoclonal antibody that targets tumor necrosis factor-alpha (TNF-alpha). It has been established that adalimumab can cross the placenta and can be detected in the fetal circulation for up to 6 months postpartum. However, clinical studies have failed to show any consistent or specific adverse fetal outcomes from maternal exposure to adalimumab during pregnancy.

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Dermatomyofibroma is a rare cutaneous mesenchymal tumor of benign fibroblastic and myofibroblastic derivations. It predominantly affects young women, and it usually presents as a reddish-brown plaque or nodule, which is commonly located over the upper trunk. We report the case of a 41-year-old female patient who presented with progressive linear dermatomyofibroma over the nape of her neck.

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Background: The accuracy of clinical diagnoses of skin diseases has not been researched in Saudi Arabia.

Objectives: Assess concordance between the histopathological and clinical diagnosis in skin diseases.

Design: Retrospective.

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Erythromelanosis follicularis faciei et colli (EFFC) is a distinct, rare, and underdiagnosed condition of unknown etiology that is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. The pigmentation is usually on both maxillary, preauricular regions, and the cheeks. We report a case of a 12-year-old boy with EFFC that was associated with reticulated pigmentation of the extremities.

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Objective: Becker's nevus (BN) is a benign cutaneous hamartoma. Although different types of lasers have been used to treat the pigmentary part of BN, to date, no definite treatment modality has been determined. The objective of this study is to evaluate the efficacy and safety of erbium: yttrium aluminum garnet (Er: YAG) laser treatment among Saudi patients with BN.

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Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported.

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Article Synopsis
  • - Dermatopathia pigmentosa reticularis (DPR) is a rare genetic skin disorder caused by mutations in keratin 14, showing an autosomal dominant inheritance pattern.
  • - The disorder is characterized by three main features: widespread reticulate hyperpigmentation, hair loss without scarring (nonscarring alopecia), and nail abnormalities (onychodystrophy).
  • - A case report discusses two Saudi brothers with DPR who presented with normal hair shafts, as determined by advanced microscopy techniques.
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Objectives: Immunogenetic factors are known to play a role in the pathogenesis of alopecia areata (AA). This study aimed at investigating the association between AA with the polymorphisms of interleukin-4 (IL-4) promoter and receptor (IL-4R) genes.

Patients And Methods: This work is a case-control study that was conducted on 76 AA patients from Qassim region, Saudi Arabia.

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Background: Vitiligo is a depigmenting skin disorder in which genetic factors play an important role.

Objective: To examine the association of CYP2C9 (*) 1/(*) 2/(*) 3 gene polymorphism with vitiligo.

Methods: In this case controlled study, 95 Saudi patients with vitiligo (50 men and 45 women), with a mean age of 27.

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Background And Objectives: Mycosis fungoides (MF) is a rare disease; and to our knowledge, there are no reports on its profile in Arabs. The objective of this study was to preliminarily analyze the clinical characteristics of MF patients seen in our institution.

Design And Setting: Retrospective review of 140 patients with pathologic or clinical diagnosis or differential diagnosis of MF for the period 2000-2006.

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Background: Reticulated acropigmentation of Kitamura (RAPK) is a pigmentary disorder of autosomal dominant inheritance, occurring predominantly within the Japanese population, for which no successful treatment has been described.

Objective: The objective was to describe a 23-year-old Saudi woman with reticulated acropigmentation of Kitamura (RAPK), who was successfully treated with a 75-nm Q-switched alexandrite laser.

Method: To report a 23-year-old Saudi woman with reticulated acropigmentation of kitamura (RAPK) who was treated with two sessions of the Q-switched alexandrite laser, six weeks apart with no recurrence after two years.

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Linear IgA bullous dermatosis is a rare sulfone-responsive subepidermal blistering disorder of unknown etiology in which smooth linear deposits of IgA are found in the basement membrane zone. Chronic bullous dermatosis of childhood is equivalent to linear IgA disease of adulthood and is characterized by an abrupt onset of large, widespread and tense bullae on a normal or erythematous base. In this case, we describe an unusual presentation of chronic bullous dermatosis in a 14-month-old Saudi girl.

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Background: Human herpesvirus 8 (HHV-8), also known as Kaposi's Sarcoma - associated herpesvirus (KSHV) was first identified and detected in 1994 in patients with Kaposi's Sarcoma. Recently, a strong association has been shown between HHV-8 and large-plaque parapsoriasis and mycosis fungoides(MF). This association has been attributed to either recent infection or reactivation of HHV-8 in patients who had extensive and/or who had an advanced stage of the diseases.

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Becker's melanosis (BM) is an uncommon cutaneous hamartoma. The classical descriptionof the lesion is of a macular, pigmented patch found on the upper trunk, with onset at or around adolescence. The aim of this study is to describe the clinicopathologic features of cases of BM which do not fit this typical description.

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Background: Linear IgA bullous dermatosis of childhood is a rare autoimmune bullous disease that mainly affects preschool-aged children. Dapsone is considered the first-line therapy with prompt response from most patients. However, it may be contraindicated in certain conditions such as glucose-6-phosphate dehydrogenase deficiency.

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