Clinical, biochemical and molecular characteristics of classic homocystinuria in Saudi Arabia and the impact of newborn screening on prevention of the complications: A tertiary center experience.

Background: Classic homocystinuria (HCU) is a rare inborn metabolic disease that is generally asymptomatic at birth. If untreated, it can cause a wide range of complications including intellectual disability, lens dislocation, and thromboembolism. This study aimed to describe the natural history and the molecular findings of patients with HCU, and to assess the importance of early diagnosis.

Effect of daily immersion of different beverages on the surface roughness and color stability of 3D-printed denture base resins.

Purpose: To measure the effect of daily immersion in varying beverages (distilled water, tea, carbonated beverage, and orange juice) on surface roughness and color stability of 3D-printed denture base resins.

Materials And Methods: 160 acrylic resin discs (15 × 2.5 mm) were made from heat-polymerized (HP), and 3D-printed resins (FormLabs, ASIGA, and NextDent).

A comparative study of strength and surface properties of permanent 3D-printed resins with CAD-CAM milled fixed dental prostheses.

Purpose: To compare the strength, surface roughness, and hardness of newly introduced permanent three-dimensional (3D)-printed resin in comparison with computer-aided design and computer-aided manufacturing (CAD-CAM) milled materials.

Materials And Methods: Three 3D-printed resins (NextDent C&B, Formlabs Permanent Crown, and VarseoSmile Crown plus) and two CAD-CAM milled (IPS e.max ZirCAD LT and VITA Enamic) resins were used to fabricate discs specimens.

Repair strength of 3D-printed denture base resins: Effect of surface treatment and repair material type.

Purpose: The aim of the study was to investigate the effect of surface treatment and repair materials on the flexural strength of repaired 3D-printed denture base resins after thermal aging.

Materials And Methods: Bar-shape specimens (64 × 10 × 3.3 mm) were designed as intact (control) specimens while repair specimens were printed in sections with 2.

Influence of different printing orientations and post-polymerization time on the translucency of three-dimensional (3D) printed denture base resins.

Purpose: To evaluate the effect of different printing orientations and post-polymerization time with thermal cycling on the translucency of 3D-printed denture base resins.

Methods: Heat-polymerized (HP) acrylic resin specimens were fabricated and 3D-printed denture base materials (NextDent, ASIGA, FormLabs) were printed with different printing orientations (0, 45, 90 degrees) and subjected to different post-polymerization times (15-, 30-, 60-, and 90-min). All specimens were polished and immersed in distilled water for 1 day at 37°C.

Mycotic Aortic Aneurysm Secondary to Salmonella enterica Infection: A Case Report and Treatment Approach.

Mycotic (infected) aortic aneurysm is a severe clinical condition with high morbidity and mortality. spp. is a Gram-negative, rod-shaped bacteria that is typically limited to the gastrointestinal tract and resolves spontaneously but can progress to invasive infections such as bacteremia.

Denture relining using digital replication method: A dental technique.

The aim of this report was to digitize traditional denture relining using a digital duplication method, in addition to assessing the wear resistance of three-dimensional (3D) printed denture teeth. A complete denture was relined using light body impression. The denture with impression was scanned yielding a standard tessellation language file that was designed to print the denture base and teeth.

In Vitro Evaluation of Candida albicans Adhesion and Related Surface Properties of CAD/CAM Denture Base Resins.

Objective:  The aim of this study was to evaluate the surface roughness, contact angle, and adhesion of to computer-aided designing/computer-aided manufacturing (CAD/CAM) and heat-polymerized (HP) denture base materials.

Materials And Methods:  Specimens were allocated to six groups based on the composition of studied denture base materials, HP acrylic resin, milled resins (AvaDent and IvoCad), and 3D-printed resins (ASIGA, FormLabs, and NextDent). Ten specimens per group were used for each test ( = 10/test).

Moyamoya Syndrome in Children With Sickle Cell Disease in Saudi Arabia: A Single-Center Experience.

Background Sickle cell disease (SCD) is relatively common in Saudi Arabia. Its neurologic complications such as stroke and Moyamoya syndrome (MMS) can be severe and devastating. Such complications can be minimized by modern investigative tools such as transcranial Doppler (TCD) ultrasound, which is unavailable in many high-risk places.

Home versus Clinic Blood Pressure Monitoring: Evaluating Applicability in Hypertension Management via Telemedicine.

Hypertension is a significant public health concern in Saudi Arabia, affecting 28.6% of the population. Despite the availability of effective treatments, optimal blood pressure control is not always achieved, highlighting the need for effective management strategies.

Effects of increasing levels of lasalocid supplementation on growth performance, serum biochemistry, ruminal fermentation profile, nutrient digestibility, and gas production of growing goats.

Introduction: Lasalocid is a feed additive widely used in ruminant nutrition and plays a crucial role in improving livestock productivity, digestibility, immunity, and overall wellbeing. The current study was conducted to investigate the effect of different levels of lasalocid (LAS) supplementation on growth performance, serum biochemistry, ruminal fermentation profile, nutrient digestibility, and gas production of growing goats.

Methods: A total of 60 growing Aardi male goats with an average body weight of ~17.

Public awareness about arthritic diseases in Saudi Arabia: a systematic review and meta-analysis.

Purpose: Raising public knowledge and perception would have a discernible impact on providing optimal care and reducing the burden of arthritis in the community. This systematic review aimed to identify the public knowledge about the common arthritic conditions in Saudi Arabia.

Methods: We searched MEDLINE, Embase, and CENTRAL for relevant literature.

Influences of Different CAD/CAM Ceramic Compositions and Thicknesses on the Mechanical Properties of Ceramic Restorations: An In Vitro Study.

The aim of this study was to assess the influences of different CAD/CAM ceramic compositions and thicknesses on the surface roughness and hardness of ceramic restorations. Four different ceramics were used in the current study: lithium disilicate (LD), leucite reinforced (LE), advanced lithium disilicate (ALD), and zirconia-reinforced lithium silicate (ZLS). Each group included 30 specimens subdivided into three different ceramic thicknesses (0.

Effect of Occlusal Splint Therapy on Condylar Movements Recorded Using an Electronic Pantograph: A Prospective Clinical Study.

Aims And Objective: The effect of occlusal splint therapy on the muscle activity has been addressed in the literature. However, its effect on condylar movements in subjects with normal and abnormal occlusions has not yet been investigated. This prospective clinical study addressed the effect of occlusal splint therapy on condylar movements in subjects with normal and abnormal occlusions using an electronic pantograph.

An Audit of Factors Impacting the Time to Resolution of the Metabolic Parameters in Diabetic Ketoacidosis Patients.

Introduction: Diabetic ketoacidosis (DKA) is a major complication affecting patients with diabetes. It is often the first presentation of type I diabetes and can also occur due to a lack of compliance with insulin therapy or infection, among other causes. Hospitalizations for DKA have increased globally among patients with type I and type II diabetes, which poses a strain on health systems.

Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis.

Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ.

Objectives: To describe the results of a systematic review for solid organ rejections following SARS-CoV-2 vaccination or COVID-19 infection.

Flexural Properties, Impact Strength, and Hardness of Nanodiamond-Modified PMMA Denture Base Resin.

Purpose: Investigate the effect of low nanodiamond (ND) addition and autoclave polymerization on the flexural strength, impact strength, and hardness of polymethylmethacrylate (PMMA) denture base.

Methods: A total of 240 heat polymerized PMMA were fabricated with low ND concentrations of 0.1%, 0.

A comparative study assessing the precision and trueness of digital and printed casts produced from several intraoral and extraoral scanners in full arch and short span (3-unit FPD) scanning: An in vitro study.

Purpose: To compare precision and trueness of digital and printed casts produced from several intraoral and extraoral scanners in full arch and short span scanning.

Materials And Methods: A fully dentate maxillary phantom cast was used to represent full arch scanning, and a mandibular phantom cast, including posterior 3-unit fixed partial denture preparations to represent short span scanning. Reference casts (RCs) were fabricated and scanned 10 times by a reference extraoral scanner (Medit T510, Seoul, Korea) to provide reference digital casts.

The Effect of Salivary pH on the Flexural Strength and Surface Properties of CAD/CAM Denture Base Materials.

Objectives:  This study aimed to evaluate the influence of different salivary pH on flexural strength, hardness, and surface roughness of computer-aided design and computer-aided manufacturing (CAD/CAM) milled and three-dimensional (3D)-printed denture base resins.

Methods:  One heat-polymerized, two CAD/CAM milled (IvoCad, AvaDent), and two 3D-printed (FormLabs, NextDent) denture base resins were fabricated and divided into five groups ( = 10) according to the solutions: three groups were immersed in different salivary pH (5.7, 7.

The Relationship Between Smoking and Multiple Sclerosis Severity in Saudi Arabia.

Introduction Multiple sclerosis (MS) is an autoimmune disease that can be disabling to patients. Smoking has been proposed to be a risk factor for MS and to increase the risk of progression of the disease and its severity. However, it is still not clear how smoking affects people with MS (PwMS) regarding disease phenotype, symptoms, relapses, course, and disability.

Flexural Properties and Hardness of CAD-CAM Denture Base Materials.

Purpose: To compare flexural strength, elastic modulus, and surface hardness of computer aided design and computer aided manufacturing CAD-CAM milled, 3D-printed, and heat-polymerized denture base resins.

Materials And Methods: A total of 120 specimens were fabricated from heat-polymerized acrylic resin (HP), milled resin (Avadent and IvoCad), and 3D-printed resin (ASIGA, FormLabs, and NextDent). The specimens were divided into 6 groups according to the type of denture base material (n = 20/material) (10/flexural properties and 10/hardness).

The post-pandemic era: will physical distancing be a perceived way of life?

This study aimed to determine whether people living in the Eastern Region of Saudi Arabia would prefer to continue the practice of physical distancing after the coronavirus disease 2019 (COVID-19) pandemic or to return to their previous way of life. This cross-sectional study was conducted from August 2020 to October 2020 in the Eastern Region of Saudi Arabia. A pre-tested questionnaire was sent electronically through social media.

CAD-CAM Fabricated Denture Base Resins: In Vitro Investigation of the Minimum Acceptable Denture Base Thickness.

Purpose: To investigate the influence of reducing material thickness on flexural properties of computer-aided design and computer-aided manufacturing (CAD-CAM) denture base resins.

Materials And Methods: Four CAD-CAM denture base acrylic resin materials were selected; two were made via the subtractive method (AvaDent and IvoCad) and two were made with the additive method (FormLabs and NextDent). One heat-polymerized denture base material was used as a control.

3D-Printable Denture Base Resin Containing SiO Nanoparticles: An In Vitro Analysis of Mechanical and Surface Properties.

Purpose: To evaluate the flexural strength (FS), impact strength (IS), surface roughness (Ra), and hardness of 3D-printed resin incorporating silicon dioxide nanoparticles (SNPs).

Materials And Methods: A total of 320 acrylic specimens were fabricated with different dimensions according to test specifications and divided into a control group of heat denture base resin, and 3 test groups (80/test (n = 10) of unmodified, 0.25 wt%, and 0.

A novel variant of gene causes mild polyglucosan myopathy.

Homozygous or compound heterozygous pathogenic variants of the gene can result in a systemic disorder characterized by the accumulation of complex carbohydrate molecules, namely polyglucosan bodies in the muscular tissues. The role of this gene in the pathophysiology of the disorder at the molecular level remains unclear. Being a very rare disorder, the medical knowledge is based on just a few reported cases.