Unfolded protein response during the progression of colorectal carcinogenesis.

Purpose: To evaluate the molecular evolution of endoplasmic reticulum (ER) stress during colorectal cancer carcinogenesis.

Methods: Fifty-six hairless mice were divided into two groups: control (no intervention); and carcinogenesis (treated with two doses of azoxymethane at 10 mg/kg during the third and the fourth week and dextran sodium sulfate at 2.5% for seven days in the second, fifth, and eighth week).

Analytical Formalism for Data Representation and Object Detection with 2D LiDAR: Application in Mobile Robotics.

In mobile robotics, LASER scanners have a wide spectrum of indoor and outdoor applications, both in structured and unstructured environments, due to their accuracy and precision. Most works that use this sensor have their own data representation and their own case-specific modeling strategies, and no common formalism is adopted. To address this issue, this manuscript presents an analytical approach for the identification and localization of objects using 2D LiDARs.

Surgical and medical outcomes in robotic compared to laparoscopic colectomy global prospective cohort from the American college of surgeons national surgical quality improvement program.

Background: Evidence regarding the outcomes benefits of robotic approach, when compared to a laparoscopic approach, in colectomy remain limited.

Objective: This study aimed to analyze the value of robotic approach compared to laparoscopic approach in minimally invasive colectomy.

Design: Cohort study of the National Surgical Quality Improvement Program (NSQIP).

The effect of aerobic and resistance exercise on the progression of colorectal cancer in an animal model.

Purpose: The aim of this study was to assess the effects of resistance and aerobic exercise on colorectal cancer (CRC) development in mice induced by azoxymethane (AOM) coupled with colitis.

Methods: Forty animals induced with CRC were used, divided into five groups of eight animals each: sedentary; continuous aerobics; continuous anaerobic; aerobic PI; and anaerobic PI. AOM was administered to the animals in two doses of 10 mg/kg each over the course of two weeks, the first dose administered in the third week and the second administered in the fourth.

The Invasive Affects Litter Decomposition, but It Does Not Change the Lignocellulolytic Fungal Community in the Atlantic Forest, Brazil.

Invasive plants affect ecosystems across various scales. In particular, they affect the quality and quantity of litter, which influences the composition of decomposing (lignocellulolytic) fungal communities. However, the relationship among the quality of invasive litter, lignocellulolytic cultivated fungal community composition, and litter decomposition rates under invasive conditions is still unknown.

Assessment of stress and anxiety in mice with colorectal cancer submitted to physical exercise.

Purpose: To evaluate the effect of physical exercise on the behavior of rodents with colorectal cancer induced through the use of elevated plus maze.

Methods: We used 40 male hairless mice induced to colorectal cancer, divided into five groups: G1) submitted to pre- and post-induction swimming; G2) pre- and post-induction ladder; G3) post-induction swimming; G4) post-induction ladder; G5) sedentary. At the end of the 14th week, the animals were submitted to the plus maze test.

SAFIIRA: A heavy-ion multi-purpose irradiation facility in Brazil.

This work describes the new facility for applied nuclear physics at the University of Sao Paulo, mainly for irradiation of electronic devices. It is a setup composed of a quadrupole doublet for beam focusing/defocusing plus multiple scattering through gold foils to produce low intensity, large-area, and high-uniformity heavy-ion beams from H to Ag. Beam intensities can be easily adjusted from 10 particles cm/s to hundreds of nA for an area as large as 2.

Discrete event simulation as a decision-making tool for end-of-life tire reverse logistics in a Brazilian city consortium.

Tires require adequate disposal at the end of their useful life due to the environmental damage that improper disposal can cause. Since the 1990s, Brazilian legislation has laid out specific rules for tire disposal. This brought about results in 2017, when 93% of the target was met for environmentally correct tire disposal, according to the Brazilian Institute of the Environment and Renewable Natural Resources.

Postpartum Depression: Epidemiological Clinical Profile of Patients Attended In a Reference Public Maternity in Salvador-BA.

Objective:  To evaluate the clinical epidemiological state of women with suspected postpartum depression (PPD) in a public maternity hospital in Salvador, state of Bahia, Brazil.

Methods:  A cross-sectional research was performed with puerperal patients attended at a public maternity hospital in Salvador, Bahia. Data collection was performed from June to September 2017.

Prevalence and factors associated with hypertriglyceridemic waist in the elderly: a population-based study.

To identify the prevalence and factors associated with hypertriglyceridemic waist (HW) in community-dwelling elderly people in northeast Brazil. Population-based cross-sectional study. Some 316 elderly (≥ 60 years) people of both sexes participated in this study.

Phylogenetic analysis of Dengue virus 1 isolated from South Minas Gerais, Brazil.

Dengue is a major worldwide public health problem, especially in the tropical and subtropical regions of the world. Primary infection with a single Dengue virus serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients who experience secondary infection with a different serotype can progress to a more severe form of the disease, called dengue hemorrhagic fever.

Multidimensional assessment of sustainability extractivism of mangrove oyster Crassostrea spp. in the estuary of Cananéia, São Paulo, Brazil.

This study was carried out with groups of extractivists of mangrove oysters in the estuary of Cananéia, São Paulo State, Brazil, between the years 1999 and 2007 with the objective to evaluate and compare trends in the sustainability of this activity, in a multidimensional and integrated way, in social, economic, ecological, technological and ethical dimensions, using the method RAPFISH. The different groups had distinct trends related to sustainability and the social, technological and ethical dimensions had more influence on trends in sustainability than the ecological and economic dimensions. The group with the best performance in the sustainability assessment was Mandira, due to advances promoted by local social organization.

Direct contact with particulate matter increases oxidative stress in different brain structures.

Introduction: Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in different brain regions, as well as the mechanisms involving its neurotoxicity, by evaluating oxidative stress parameters in vitro.

Methods: Olfactory bulb, cerebral cortex, striatum, hippocampus and cerebellum of rats were homogenized and incubated with PM < 2.

Sonographic evaluation of the thyroid size in neonates.

Purpose: To validate the use of the ratio between the total transverse diameters of the thyroid lobes (Th) and the width of the trachea (Tr)-the Th:Tr or Yasumoto ratio-as a sonographic method for estimating thyroid size, and to determine reference values for this ratio and for thyroid volume in neonates.

Methods: In this cross-sectional study, we evaluated thyroid size according to the Yasumoto ratio and the thyroid volume calculated with the ellipsoid formula in 125 healthy, euthyroid, iodine-sufficient, full-term neonates.

Results: The mean thyroid gland volume was 1.

[Health policies for tobacco control in Latin America and the Caribbean: an integrative review].

The habit of smoking is an increasing concern for governments, health authorities and society as a whole, as it is a legal drug, which is addictive and leads to serious damage to health. Cigarette smoking causes about 5.4 million deaths/year worldwide and is the second major risk factor for deaths.

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men.

Background: Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions.

Sexually transmitted diseases in a specialized STD healthcare center: epidemiology and demographic profile from January 1999 to December 2009.

Background: Sexually Transmitted Diseases are still considered a serious public health problem in Brazil and worldwide.

Objective: To examine Sexually Transmitted Diseases prevalence and the sickness impact profile of STDs in a reference health center specializing in the treatment of Sexually Transmitted Diseases.

Method: We collected epidemiological, demographic, clinical and laboratory data from the medical records and interviews of 4,128 patients who had attended the center from January 1999 to December 2009.

Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.

Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves' ethanol extract were investigated in animal models. The extract (p.o.

Pre and post-natal exposure to ambient level of air pollution impairs memory of rats: the role of oxidative stress.

The aims of this study were to evaluate whether air pollution during pre-natal and post-natal phases change habituation and short-term discriminative memories and if oxidants are involved in this process. As secondary objectives, it was to evaluate if the change of filtered to nonfiltered environment could protect the cortex of rats against oxidative stress as well as to modify the behavior of these animals. Wistar, male rats were divided into four groups (n = 12/group): pre and post-natal exposure until adulthood to filtered air (FA); pre-natal period to nonfiltered air (NFA-FA); until (21st post-natal day) and post-natal to filtered air until adulthood (PND21); pre-natal to filtered air until PND21 and post-natal to nonfiltered air until adulthood (FA-NFA); pre and post-natal to nonfiltered air (NFA).

Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae.

Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance.

Diagnostic accuracy of fetal renal pelvis anteroposterior diameter as a predictor of uropathy: a prospective study.

Objective: The purpose of this study was to assess the accuracy of prenatal ultrasound measurement of anteroposterior renal pelvis diameter (APD) to discriminate between significant uropathy and idiopathic renal pelvis dilatation.

Methods: One-hundred-and-three neonates who were found to have fetal renal pelvis dilatation, defined as presence of an APD > or = 5 mm, underwent systematic investigation for uropathies and were prospectively followed. An ultrasound scan was performed after the first week of postnatal life and all infants underwent a voiding cystourethrogram.

Diagnostic accuracy of postnatal renal pelvic diameter as a predictor of uropathy: a prospective study.

Background: There is a necessity to standardize postnatal ultrasonographic markers predictive of significant uropathies. The purpose of this study was to assess the accuracy of anteroposterior renal pelvic diameter (APD) on postnatal ultrasound to discriminate between significant uropathy and idiopathic renal pelvic dilatation.

Materials And Methods: Neonates ( n=110) who were found to have isolated fetal renal pelvic dilatation underwent systematic investigation and were prospectively followed up.