Publications by authors named "Fagun Jain"
Article Synopsis
- The study investigates differences in thrombo-inflammatory responses and outcomes between non-COVID-19 community-acquired pneumonia (CAP) and COVID-19 CAP in hospitalized adults in Canada.
- Non-COVID-19 CAP patients displayed lower 28-day mortality rates and fewer complications compared to those with COVID-19, indicating a more effective immune response developed over time against bacterial infections.
- The findings suggest that the complexities of the immune response to COVID-19 resulted in higher mortality rates, highlighting the challenges posed by emerging viruses compared to known pathogens.
Background: Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and community hospitals with respect to their demographics, clinical characteristics, treatments and outcomes.
Methods: This nested observational cohort substudy of the Community Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) trial included 1,329 hospitalized adults with CAP recruited between March 1st, 2018 and September 31st, 2023 from 15 Canadian hospitals.
Article Synopsis
- * Researchers analyzed protein levels in 74 patients at three different time points after diagnosis, using a method called multiple reaction monitoring on 269 peptides, alongside routine lung function tests.
- * The study found increases in proteins linked to lipid-related pathways over time, while those related to immune responses decreased; it also noted significant differences in protein concentrations between males and females affecting lung function.
Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.
Pigment Cell Melanoma Res
November 2020
The G-protein-coupled receptor, endothelin receptor B (EDNRB), is an important regulator of melanocyte survival and proliferation. It acts by stimulating downstream heterotrimeric G proteins, such as Gα and Gα . Constitutively active, oncogenic versions of Gα and Gα drive melanomagenesis, but the role of Ednrb in the context of these mutant G proteins has not been previously examined.
View Article and Find Full Text PDFMelanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
Pigment Cell Melanoma Res
November 2018
The mouse tail has an important role in the study of melanogenesis, because mouse tail skin can be used to model human skin pigmentation. To better understand the development of melanocytes in the mouse tail, we cloned two dominant ENU-generated mutations of the Adamts9 gene, Und3 and Und4, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the mouse. Adamts9 encodes a widely expressed zinc metalloprotease with thrombospondin type 1 repeats with few known substrates.
View Article and Find Full Text PDFThe glandular hair extracts from the fruit rind of Mallotus philippinensis Muell. is employed to treat various skin infections, however the anti-tyrosinase activity remains unknown. Hence the present study inspected on the anti-melanogenic activity of M.
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