Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion.

Cell invasion targets specific tissues in physiological placental implantation and pathological metastasis, which raises questions about how this process is controlled. We compare dermis and endometrium capacities to support trophoblast invasion, using matching sets of human primary fibroblasts in a coculture assay with human placental explants. Substituting endometrium, the natural trophoblast target, with dermis dramatically reduces trophoblast interstitial invasion.

Opposite effects of transforming growth factor-beta activation and rho-associated kinase inhibition on human trophoblast migration in a reconstituted placental-endometrial coculture system.

Placental implantation involves highly regulated trophoblast invasion of the endometrial stroma. TGFbeta is a known regulator of this process. This study examines the effect of TGFbeta on extravillous cytotrophoblastic cell (EVCT) migration in cocultures of first-trimester human chorionic villus explants and primary human endometrial fibroblasts.

Cell type-dependent control of NF-Y activity by TGF-beta.

Transforming growth factor beta (TGF-beta) is a pluripotent cytokine that regulates cell growth and differentiation in a cell type-dependent fashion. TGF-beta exerts its effects through the activation of several signaling pathways. One involves membrane proximal events that lead to nuclear translocation of members of the Smad family of transcriptional regulators.

[Internal hernia of the small intestine through a breach of the broad ligament, apropos of a case. Review of the literature].

Strangulated herniation of bowel occurring through a defect of the broad ligament is extremely rare. A recent episode of such a herniation of small bowel through the left mesosalpynx is presented. A review of literature reveals 61 cases previously reported.