Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation.

There is considerable scientific interest in understanding the strains that tendon cells experience in situ and how these strains influence tissue remodeling. Based on this interest, several analytical techniques have been developed to measure local tissue strains within tendon explants during loading. However, in several cases, the accuracy and sensitivity of these techniques have not been reported, and none of the algorithms are publicly available.

Morphological changes in glial cells arrangement under mechanical loading: A quantitative study.

The mechanical properties and microstructure of brain tissue, as its two main physical parameters, could be affected by mechanical stimuli. In previous studies, microstructural alterations due to mechanical loading have received less attention than the mechanical properties of the tissue. Therefore, the current study aimed to investigate the effect of ex-vivo mechanical forces on the micro-architecture of brain tissue including axons and glial cells.

Effects of lumbar spinal disorders on the vertical ground reaction force and Spatio-temporal parameters in gait.

Background: Ground reaction forces are biomechanical data, providing information to investigate pathological gait. The vertical component of ground reaction force introduces the upward thrust force within gait progression. Although alterations in the vertical component in patients with spinal disorders were addressed in the literature, still the corresponding effect on spinal disorders is a major issue to scrutiny.

The effect of large deformation on Poisson's ratio of brain white matter: An experimental study.

A more Accurate description of the mechanical behavior of brain tissue could improve the results of computational models. While most studies have assumed brain tissue as an incompressible material with constant Poisson's ratio of almost 0.5 and constructed their modeling approach according to this assumption, the relationship between this ratio and levels of applied strains has not yet been studied.

Mind the gap: A mechanobiological hypothesis for the role of gap junctions in the mechanical properties of injured brain tissue.

Despite more than half a century of work on the brain biomechanics, there are still significant unknowns about this tissue. Since the brain is highly susceptible to injury, damage biomechanics has been one of the main areas of interest to the researchers in the field of brain biomechanics. In many previous studies, mechanical properties of brain tissue under sub-injury and injury level loading conditions have been addressed; however, to the best of our knowledge, the role of cell-cell interactions in the mechanical behavior of brain tissue has not been well examined yet.

The importance of axonal directions in the brainstem injury during neurosurgical interventions.

Brainstem, which connects the distal part of the brain and the spinal cord, contains main motor and sensory nerves and facilitates communication between the cerebrum, cerebellum, and spinal cord. Due to the complicated anatomy and neurostructure of brainstem, surgical interventions to resect brainstem tumors are particularly challenging, and new approaches to reduce the risk of surgical brain injury are of utmost importance. Although previous studies have investigated the structural anisotropy of brain white matter, the effect of axonal fibers on the mechanical properties of white matter has not yet been fully understood.

Structural Anisotropy vs. Mechanical Anisotropy: The Contribution of Axonal Fibers to the Material Properties of Brain White Matter.

Brain's micro-structure plays a critical role in its macro-structure material properties. Since the structural anisotropy in the brain white matter has been introduced due to axonal fibers, considering the direction of axons in the continuum models has been mediated to improve the results of computational simulations. The aim of the current study was to investigate the role of fiber direction in the material properties of brain white matter and compare the mechanical behavior of the anisotropic white matter and the isotropic gray matter.

Tension Strain-Softening and Compression Strain-Stiffening Behavior of Brain White Matter.

Brain, the most important component of the central nervous system (CNS), is a soft tissue with a complex structure. Understanding the role of brain tissue microstructure in mechanical properties is essential to have a more profound knowledge of how brain development, disease, and injury occur. While many studies have investigated the mechanical behavior of brain tissue under various loading conditions, there has not been a clear explanation for variation reported for material properties of brain tissue.

A knowledge map analysis of brain biomechanics: Current evidence and future directions.

Although brain, one of the most complex organs in the mammalian body, has been subjected to many studies from physiological and pathological points of view, there remain significant gaps in the available knowledge regarding its biomechanics. This article reviews the research trends in brain biomechanics with a focus on injury. We used published scientific articles indexed by Web of Science database over the past 40 years and tried to address the gaps that still exist in this field.