Insomnia patients have a poor intestinal prognosis: Accompanied by microbiota-derived short chain fatty acids, diet and zonulin.

Background: It is becoming increasingly clear that the relationship between sleep disturbance and gut microbiota metabolites is of great importance.

Aims: This study aimed to examine the changes in microbiota metabolites, brain-derived neurotrophic factors and synaptic proteins in insomnia patients, with a particular focus on the impact of diet.

Methods: A total of 41 patients with insomnia and 45 healthy individuals participated in the study.