Publications by authors named "Fadila Rayah-Benhamed"
Article Synopsis
- ChREBP is a crucial protein in the liver that regulates genes involved in sugar and fat metabolism, and inhibiting it in obese mice prevents fatty liver disease.
- The study explored how O-GlcNAcylation, a process involving the addition of a sugar molecule, affects ChREBP activity; this process is managed by two enzymes, OGT and OGA.
- Results showed that O-GlcNAcylation stabilizes ChREBP and boosts its activity, leading to increased fat storage in the liver, but enhancing OGA activity can reduce fat buildup and improve metabolic health.
