Oxymetazoline ototoxicity in a chinchilla animal model.

Objective: To investigate possible ototoxic effects of a one-time application of oxymetazoline drops in a chinchilla animal model with tympanostomy tubes. Study Design. A prospective, controlled animal study.

Ototoxicity of topical moxifloxacin in a chinchilla animal model.

Objective: Ciprofloxacin is currently the only proven nonototoxic topical antibiotic. However, its widespread use has resulted in the emergence of antimicrobial resistance. There are also concerns that there is currently no safe alternative to ciprofloxacin for patients with a nonintact eardrum.

Ototoxicity of triethanolamine polypeptide (cerumenex) in the chinchilla.

Unlabelled: The use of earwax softeners and cerumenolytics to unblock the external auditory canal is increasing. Although reports on their effectiveness are available, data about their effect on hearing are limited.

Objective: To assess the effect of ototopic triethanolamine polypeptide oleate condensate 10% (Cerumenex) on hearing.