Publications by authors named "Fadhil Abubaker"
Article Synopsis
- - The study focuses on developing new strategies for diabetes treatment using human pluripotent stem cells (hPSCs) to create insulin-secreting beta cells, specifically examining a new type of pancreatic progenitors identified as PDX1/NKX6.1.
- - Researchers differentiated three hPSC lines into these PDX1/NKX6.1 progenitors and assessed their ability to become functional beta cells through various protocols, including transcriptome analysis.
- - The results showed that these progenitors could efficiently develop into insulin-secreting cells that respond to glucose, highlighting their potential as a novel source for beta cell therapy in diabetes treatment.
Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes (KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular diseases. The debate on the genetic origin of psoriasis pathogenesis remains unresolved due to lack of suitable in vitro human models mimicking the disease phenotypes.
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