Publications by authors named "Fadel Guillaume"
Targeted vasopeptide therapies have significantly advanced the management of pulmonary arterial hypertension (PAH). However, due to insufficient preclinical evidence regarding the involvement of the endothelin-1 (ET-1) pathway in chronic thromboembolic pulmonary hypertension (CTEPH) pathophysiology, the potential of ET-1 receptor antagonism in treating CTEPH remains uncertain. In this study, we investigated the role of the ET-1 pathway in CTEPH microvasculopathy using a multifaceted approach.
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- Heart transplantation is crucial for patients with advanced heart failure, but there's a shortage of donor organs, leading to the increased use of extended criteria donors (ECD).
- Many ECDs at risk for coronary artery disease do not undergo standard coronary angiography, resulting in some hearts being declined or procured without proper screening.
- The described protocol demonstrates a new method for performing coronary angiography during normothermic ex-situ heart perfusion (NESP), showing it to be reproducible without affecting heart viability and potentially improving ECD procurement rates.
Robotic-assisted thoracic surgery training in France: a nation-wide survey from young surgeons.
Interdiscip Cardiovasc Thorac Surg
July 2024
Article Synopsis
- A study was conducted to assess the training of thoracic surgeons-in-training in robotic-assisted thoracic surgery (RATS) across France, gathering responses from 101 participants.
- Over half of the trainees had access to robotic systems, with a significant number considering robotic training essential, though only a small percentage had performed a complete procedure independently.
- The findings suggest that training opportunities vary by institution, with higher exposure and performance among fellows at high-volume centers, highlighting the need for increased access and simulation training to improve skills in RATS.
Article Synopsis
- En-bloc complete resection is the preferred method for treating localized chest wall tumors, with titanium bar reconstruction showing good early results but limited long-term data available.
- A study reviewed 68 patients from 2012 to 2018 who had CW tumor resections and titanium repairs, achieving a 94% complete resection rate and tracking survival outcomes over time.
- Results indicated that there were decent survival rates at 1, 3, and 5 years, with some complications including surgical site infections and chronic pain, but no reports of titanium allergy or flail chest.
Background: Despite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving extracorporeal membrane oxygenation with a diagnosis of COVID-19 in France and to identify pre-extracorporeal membrane oxygenation factors associated with in-hospital mortality. A hypothesis of similar mortality rates and risk factors for COVID-19 and non-COVID-19 patients on venovenous extracorporeal membrane oxygenation was made.
View Article and Find Full Text PDFObjective: The aim was to describe initial outcomes of physician modified stent grafts using antegrade laser fenestrations and image fusion guidance (LEVAR) and company manufactured custom made (CM) stent grafts for the treatment of complex abdominal aortic aneurysms (CAAAs), thoraco-abdominal aortic aneurysms (TAAAs) and type I endoleaks (T1ELs).
Methods: This was a retrospective single centre study. All LEVAR and Zenith (Cook) CM stent graft procedures between 1 January 2012 and 31 December 2018 were reviewed.
This study determined whether novel right heart echocardiography metrics help to detect pulmonary hypertension (PH) in patients with advanced lung disease (ALD). We reviewed echocardiography and catheterization data of 192 patients from the Stanford ALD registry and echocardiograms of 50 healthy controls. Accuracy of echocardiographic right heart metrics to detect PH was assessed using logistic regression and area under the ROC curves (AUC) analysis.
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