Comparison of dried matrix spots and fabric phase sorptive extraction methods for quantification of highly potent analgesic activity agent (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol in rat whole blood and plasma using LC-MS/MS.

The methods for quantification of highly potent analgesic agent (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol in rat whole blood and plasma were developed and validated using dried matrix spots (DMS) or fabric phase sorptive extraction (FPSE) techniques in combination with LC-MS/MS. 2-Adamantylamine hydrochloride was used as an internal standard (IS). Chromatographic separation was carried out on a reversed-phase column (2.

[The effect of intravitreally administered angiogenesis inhibitor on the concentration of angiotensin-converting enzyme in the blood serum and lacrimal fluid in patients with diabetic macular edema].

Background: Diabetic retinopathy (DR) is one of the more serious complications of diabetes and the main cause of blindness among working-age individuals. In recent years, information has emerged on the possible role of the renin-angiotensin system (RAS) in the pathogenesis of DR, and DR's possible connection with the system of pro-angiogenic factors.

Aim: To study the impact of anti-angiogenic therapy on systemic and local concentrations of angiotensin-converting enzyme (ACE), a key component of RAS, for patients with diabetic macular edema (DME).

[Possibilities of multicolor confocal scanning laser ophthalmoscopy in complex diagnostics of severe proliferative diabetic retinopathy].

Unlabelled: Multicolor scanning laser ophthalmoscopy (multicolor SLO) is a new informative method of eye fundus visualization. The method is based on synchronously obtaining three separate confocal images with monochromatic laser sources - blue (488 nm), green (515 nm) and infrared (820 nm), which are then combined into one in the Multicolor mode.

Purpose: To evaluate the informative value of multicolor SLO in a complex examination of patients with severe proliferative diabetic retinopathy (PDR).

[Impact of antiangiogenic therapy on ocular blood flow and microcirculation in diabetic macular edema].

Unlabelled: Today, diabetic macular edema (DME) is still one of the main causes of vision loss in patients with diabetes.

Purpose: To identify changes in the ocular blood flow and microvascular network of the macular zone in patients with DME after antiangiogenic therapy.

Material And Methods: In the course of the study, 25 patients (50 eyes) with monolateral clinically significant DME aged 67.

[Role of optical coherence tomography angiography in diagnostics of early choroidal melanoma and circumscribed choroidal hemangioma].

Unlabelled: Small choroidal melanoma is a malignant tumor that is prone to early metastasis, its amelanotic form is often similar to circumscribed choroidal hemangioma. The main attribute for tumor identification is its vascularization, which is the target of various examination methods. Optical coherence tomography angiography (OCTA) has not been previously used in complex diagnostics of early choroidal melanoma and circumscribed choroidal hemangioma for detection of tumor vessels and the nature of their branching, as well as for vessel caliber comparison.

Sorption of noble-metal ions on silica with chemically bonded nitrogen-containing ligands.

A study has been made of the sorption of Ir(IV), Rh(III), Pt(IV), Ru(IV), Os(VIII), Pd(II) and Au(III) from aqueous solutions by silica chemically modified with nitrogen-containing organic ligands, as a function of hydrochloric acid concentration, time of contact, concentration of the element and the ionic strength. Sorption of noble-metal ions at pH > 1 on a sorbent containing monoamine groups seems to be due to a complexation mechanism, and to an anion-exchange mechanism at pH < 1. With aminopropyl-silica 1000-fold concentration of Ir(IV) and Rh(III) from their 10(-8)-10(-7)M solutions was achieved and these metals were subsequently determined on the sorbent surface by X-ray fluorescence.

[Atopic dermatitis in pregnant women].

Thirty-six patients with atopic dermatitis exacerbating during pregnancy are described. Case histories, the disease course, and the earlier therapy for this condition are analyzed, and the treatment administered to these patients with due consideration for the pregnancy dates is described. Recommendations on the follow-up of pregnant patients with atopic dermatitis are given.

Concentration, separation and determination of scandium, zirconium, hafnium and thorium with a silica-based sulphonic acid cation-exchanger.

A study has been made of the dependence of the sorption of scandium, zirconium, hafnium and thorium from aqueous solutions with a silica-based sulphonic cation-exchanger (SCE-SiO(2)) on the concentration and nature of the acid medium, time of contact, concentration of the element, and the ionic strength. The selectivity decreases in the order Zr approximately Hf > Th > Sc > Fe(III). The sorption characteristics of silica gel and SCE-SiO(2) have been compared, and the sorption mechanism is discussed.

[Increased body sensitivity of the rat to SO2 exposure in prolonged hypokinesia].

The effect of atmospheric contaminants on animals exposed to prolonged hypokinesia was investigated. A quantitative correlation between the resistance and the concentration of an atmospheric contaminant (sulfur oxide-SO2) was established, using concentration-time and concentration-effect relations.