Publications by authors named "Facundo Di Diego"
Background: Despite that pediatric COVID-19 is usually asymptomatic or mild, SARS-CoV-2 infection typically results in the development of an antibody response. Contradictory observations have been reported when the antibody response of children and adults were compared in terms of strength, specificity and perdurability.
Methods: This observational study includes three cohorts infected with SARS-CoV-2 between March 2020-July 2021: unvaccinated infected children (n=115), unvaccinated infected adults (n=62), and vaccinated infected children (n=76).
Article Synopsis
- Neutrophils in severe COVID-19 show increased activation markers and produce inflammatory signals like CXCL8 and CCL2.
- Their activity correlates with markers of tissue damage, such as lactate dehydrogenase and D-dimer levels in the blood.
- Immune complexes, particularly involving specific antibodies, may enhance neutrophil inflammation, potentially worsening COVID-19 severity.