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Publications by authors named "Facheng Ma"

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Discovery of a Potent and Orally Bioavailable Xanthine Oxidase/Urate Transporter 1 Dual Inhibitor as a Potential Treatment for Hyperuricemia and Gout.
Xinye Yang Yong Li Shengqiang Pan Facheng Ma Hong Chen

J Med Chem

August 2024

Article Synopsis
  • - The main treatments for hyperuricemia and gout are xanthine oxidase (XO) inhibitors and urate transporter 1 (URAT1) inhibitors, but these have limitations in effectiveness and safety.
  • - Researchers developed a new dual inhibitor that targets both XO and URAT1 to potentially improve treatment outcomes and reduce toxicity.
  • - This new compound showed strong inhibition of both targets and favorable safety profiles in animal studies, making it a promising candidate for gout treatment.
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