Quantitative NMR Spectrometry of Phenylpropanoids, including Isoeugenol in Herbs, Spices, and Essential Oils.

Isoeugenol (2-methoxy-4-(1-propenyl)phenol) has been recently classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). This study conducted an analysis of isoeugenol in common herbs and spices, including basil, cinnamon, ginger, and nutmeg, using H nuclear magnetic resonance (NMR) spectrometry. Additionally, over 1300 coffee samples were analysed by H-NMR for isoeugenol, but it was not detected in any of the analysed samples.

The Prescription of Drug Ontology 2.0 (PDRO): More Than the Sum of Its Parts.

While drugs and related products have profoundly changed the lives of people around the world, ongoing challenges remain, including inappropriate use of a drug product. Inappropriate uses can be explained in part by ambiguous or incomplete information, for example, missing reasons for treatments, ambiguous information on how to take a medication, or lack of information on medication-related events outside the health care system. In order to fully assess the situation, data from multiple systems (electronic medical records, pharmacy and radiology information systems, laboratory management systems, etc.

Correction: Modulation of the mechanical energy storage performance of the MIL-47(V) metal organic framework by ligand functionalization.

Correction for 'Modulation of the mechanical energy storage performance of the MIL-47(VIV) metal organic framework by ligand functionalization' by Pascal G. Yot et al., Dalton Trans.

Modulation of the mechanical energy storage performance of the MIL-47(V) metal organic framework by ligand functionalization.

The functionalization of the metal-organic framework MIL-47(V) with ligands bearing bulky functional groups (-Br or -CF) has been envisaged as a possible route to enhance the mechanical energy storage performances of this family of hybrid porous materials. This exploratory work was carried out by coupling advanced experimental techniques (mercury intrusion and X-ray powder diffraction) supported by density functional theory calculations. MIL-47(V)-BDC-CF was demonstrated to be one of the most promising porous materials for mechanical energy-related applications with performance in terms of work energy which surpasses that of any porous solids reported so far.

Thermodynamics of the structural transition in metal-organic frameworks.

A thermodynamic study of the structural large-pore (LP) to narrow pore (NP) transition in various Metal Organic Frameworks (MOFs) is presented. First, the pressure induced transition at a constant temperature is investigated using a Tian-Calvet microcalorimeter set-up equipped with a high pressure cell. This device permits simultaneous measurements of the mechanical work and heat associated with the LP → NP transition.

Design of hydrophilic metal organic framework water adsorbents for heat reallocation.

A new hydrothermally stable Al polycarboxylate metal-organic framework (MOF) based on a heteroatom bio-derived aromatic spacer is designed through a template-free green synthesis process. It appears that in some test conditions this MOF outperforms the heat reallocation performances of commercial SAPO-34.

The structure of the aluminum fumarate metal-organic framework A520.

The synthesis of the commercially available aluminum fumarate sample A520 has been optimized and its structure analyzed through a combination of powder diffraction, solid-state NMR spectroscopy, molecular simulation, IR spectroscopy, and thermal analysis. A520 is an analogue of the MIL-53(Al)-BDC solid, but with a more rigid behavior. The differences between the commercial and the optimized samples in terms of defects have been investigated by in situ IR spectroscopy and correlated to their catalytic activity for ethanol dehydration.

Determinants of A (H1N1) vaccination: cross-sectional study in a population of pregnant women in Quebec.

Background: Because of the risk of complication, pregnant women were a priority target for vaccination during the A (H1N1) pandemic influenza. In Quebec, 63% of pregnant women were vaccinated, which is a higher rate than vaccination against seasonal influenza. However, the behaviour of pregnant women relative to the vaccination during the H1N1 pandemic is unknown.

Application of neural network calibrations to an halide ISE array.

The Neural Network (NN) technique was applied to the calibration of an ion selective electrode (ISE) array comprising a bromide selective electrode, two chloride ISEs and one thiocyanate ISE. The measured samples were synthetic mixture solutions of chlorides and bromides in concentration ranges such that interference occurs. The NN method allowed to perform the calibration without estimating the coefficients of the Nikolskii-Eisenman theoretical relation.

Halide ion-selective electrode array calibration.

The calibration of several ions (Cl(-), Br(-), F(-) and OH(-)) measured with an ion selective electrodes (ISE) array has been carried out in the presence of interferents using an experimental design and multivariate calibration methods. Partial least squares regression and principal component regression do not seem to improve the test set prediction compared to multivariate linear regression. In the case of very slight or no interference on the ISE, each ion can be determined using the corresponding ISE and univariate calibration methods, but the use of multivariate methods does not lead to worse results.

Reactivity of NASICON with water and interpretation of the detection limit of a NASICON based Na(+) ion selective electrode.

The leaching of Na(+) ions from NASICON of composition Na(3)Zr(2)Si(2)PO(12) to the aqueous solution was evidenced. The origin of the Na(+) leaching was studied using Na(+) concentration and pH measurements as well as solution and X-ray analyses. The Na(+) released was mainly attributed to the dissolution of a second phase, predominantly amorphous.

Using argumentation to extract key sentences from biomedical abstracts.

Problem: key word assignment has been largely used in MEDLINE to provide an indicative "gist" of the content of articles and to help retrieving biomedical articles. Abstracts are also used for this purpose. However with usually more than 300 words, MEDLINE abstracts can still be regarded as long documents; therefore we design a system to select a unique key sentence.

Methodology to ease the construction of a terminology of problems.

Introduction: Problem lists summarize an aspect of the patient's medical history and provide an important way to implement entry points for clinical pathways and guideline-oriented care. However, in order to automate processes based on problem lists, the use of controlled vocabularies is required. We developed a methodology to extract a collection of standardized problem-related terms from medical documents entered in free text by physicians.

Amplification of Terminologia anatomica by French language terms using Latin terms matching algorithm: a prototype for other language.

Objective: Terminologia anatomica is the new standard in anatomical terminology. This terminology is available only in Latin and English and its worldwide adoption is subject to the addition of terms from others languages. On the other hand, Nomina anatomica, the previous standard, has been widely translated.

Towards a multilingual version of terminologia anatomica.

Objective: Terminologia Anatomica (TA) is the new standard in anatomical terminology. This terminology is available only in Latin and English and its worldwide adoption is subdued to the addition of terms from others languages. On the other hand Nomina Anatomica (NA), the previous standard, has been widely translated.

Desiderata for representing anatomical knowledge.

The general problem of knowledge representation for gross anatomy supporting both computers and human is rarely globally solved. Partial solutions are flourishing, but the actual and potential users are left with a lack of satisfaction and uncomfortable feeling of incompleteness. Moreover, these solutions are not ready for a sound evolution and are at risk to disappear at any moment by default of adequate maintenance.

User acceptance of clinical information systems: a methodological approach to identify the key dimensions allowing a reliable evaluation framework.

The introduction of Computerized Information Systems (CIS) in clinical settings encountered difficulties. These difficulties highlight the lack of understanding of factors and mechanisms influencing user acceptance. The existing tools and research obtained contradictory results that point out the existence of neglected aspects, such as impacts of CIS, in computer science developments in complex settings.

Coping with the variability of medical terms.

Objectives: To cope with medical terms, which present a high variability of expression through a single natural language, in the sense that any term may be reformulated in hundred of different ways.

Methods: A typology of term variants is presented as a systematic approach in order to favour the implementation of an exhaustive solution. Then, an algorithm able to handle all variants is designed.

Clinical documents: attribute-values entity representation,context, page layout and communication.

This paper presents how acquisition, storage and communication of clinical documents is implemented at the University Hospitals of Geneva. Careful attention has been given to user-interfaces, in order to support complex layouts, spell checking, and templates management with automatic prefilling. A dual architecture has been developed for storage using an entity-attribute-value unified database and a consolidated, patient-centered, layout-respectful file-based storage, providing both representation power and speed of access.

A frame-based representation of ICD-10.

Unlabelled: Physicians are required to code information concerning a patient's stay in order to measure the medical activity in hospitals. They use the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10). Coding is usually performed manually and computerized tools may be useful in speeding up and facilitating the tedious task of coding patient information.

Non-polarisable dry electrode based on NASICON ceramic.

A NASICON-type ceramic (high sodium ion conductor) is proposed to record bioelectric signals. The electrode does not need gel before its application. The principle of the measurements is based on a sodium ion exchange between the skin and the material.

Sucrose induced hypertriglyceridaemia: its mechanism and metabolic effects.

The study summarizes the metabolic effects of increased sucrose or fructose intake. Compared with the traditional carbohydrate source-starch, a high intake of the above two carbohydrates produces a number of metabolic and other changes that can have a pathological effect. A thus induced metabolic and other changes that can have hepatic lipid synthesis, hypertriglyceridaemia and increased tissue lipid utilization, while tissue glucose utilization decreases.