Publications by authors named "Fabrizio Turrini"

Aims: An increase in right atrial pressure is a common feature of acute decompensated heart failure (ADHF). Such increased pressure leads to persistent kidney congestion. A marker to guide optimal diuretic therapy is missing.

View Article and Find Full Text PDF

Background: It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed over the course of the pandemic.

Methods: Prospective, observational registry constituted by 90 ICUs across 22 countries worldwide including patients with a laboratory-confirmed, critical presentation of COVID-19 requiring advanced organ support. Hierarchical, generalized linear mixed-effect models accounting for hospital and country variability were employed to analyse the continuous evolution of the studied variables over the pandemic.

View Article and Find Full Text PDF
Article Synopsis
  • Acute myocarditis (AM) is recognized as a rare but serious cardiovascular complication in COVID-19 patients, with a study analyzing data from 112 suspected cases in hospitalized patients across the U.S. and Europe.
  • The prevalence of definite/probable AM was found to be 2.4 per 1000 hospitalizations, with common symptoms including chest pain and dyspnea, particularly in younger adults averaging 38 years of age.
  • The study revealed significant challenges, such as 20.4% experiencing in-hospital mortality or requiring advanced support, with a notably higher mortality rate in patients who also had pneumonia.
View Article and Find Full Text PDF

Background: Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates.

View Article and Find Full Text PDF

This study examined the association between dynamic angiopoietin-2 assessment and COVID-19 short- and long-term clinical course. We included consecutive hospitalized patients from 1 February to 31 May 2020 with laboratory-confirmed COVID-19 from 2 Italian tertiary referral centers (derivation cohort, n = 187 patients; validation cohort, n = 62 patients). Serum biomarker levels were measured by sandwich enzyme-linked immunosorbent assay.

View Article and Find Full Text PDF

Background: The aim of this study was to investigate the effects of vitamin D (VD) on the interaction among functional, echocardiographic and hormonal parameters in patients with heart failure (HF) and VD deficiency.

Methods: In a randomized, double blind trial, 35 patients with HF and VD<20 ng/mL, received either 300,000 U of oral cholecalciferol followed by 50,000 U/month for 6 months, or placebo treatment.

Results: Changes in the 6 Minute Walking Test (6MWT) assessed at 3 and 6 months in treatment group was the primary end point.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the role of right ventricular presystolic peak velocity (RVPrP) in assessing right ventricular (RV) function, particularly in stable patients with cardiovascular risk factors, as RV function impacts patient morbidity and mortality.
  • - A total of 436 patients underwent echocardiographic assessments, revealing that RVPrP was significantly lower in patients with RV dysfunction compared to those with preserved function, indicating its potential as a useful marker.
  • - The findings suggest that RVPrP can help detect RV dysfunction in stable patients, highlighting its relationship with other echocardiographic parameters like TAPSE and RV Systolic Peak (RVSyP), despite the latter showing poor agreement in defining dysfunction.
View Article and Find Full Text PDF

Objectives: To evaluate if screening and treatment of asymptomatic coronary artery disease (CAD) are effective in preventing first cardiac event in diabetics.

Methods: Diabetic patients without known CAD were randomly assigned to undergo a screening for silent myocardial ischemia followed by revascularization or to continue follow-up. The reduction of cardiac death (CD) or nonfatal myocardial infarction (MI) represented the primary aim; secondary aim was the prevention of heart failure (HF).

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to evaluate the effectiveness of screening asymptomatic diabetic patients for coronary artery disease (CAD) and the benefits of revascularization in those identified as high-risk.
  • Diabetic patients will be screened at outpatient services, with participants randomized into two groups: one undergoing exercise tolerance testing and the other receiving standard care.
  • Findings will inform prevention strategies for high-risk diabetic patients and assess the feasibility of implementing this screening approach in real-world settings.
View Article and Find Full Text PDF

Venous thromboembolism (VTE) is a common complication among hospitalized patients. Pharmacological thromboprophylaxis has emerged as the cornerstone for VTE prevention. As trials on thromboprophylaxis in medical patients have proven the efficacy of both low-molecular-weight heparins (LMWHs) and unfractionated heparin (UFH), all acutely medical ill patients should be considered for pharmacological thromboprophylaxis.

View Article and Find Full Text PDF

The aim of this prospective cohort study was to determine the incidence of dalteparin bioaccumulation (measured using anti-Xa levels), and bleeding during thromboprophylaxis in elderly patients with renal failure who were admitted to hospital with an acute medical illness. Patients who met the criteria for being at high thromboembolic risk received dalteparin 5,000 IU subcutaneously once daily while the other patients (low risk) received 2,500 IU daily. Thromboprophylaxis was administered for at least 6 days.

View Article and Find Full Text PDF

Between 1991 and 1998, 45 cirrhotic patients with hepatocellular carcinoma (1 or 2 lesions smaller than 5 cm) were treated either with percutaneous ethanol injection (26 patients) or with trans arterial chemoembolization (19 patients) in our Department. Percutaneous ethanol injection was performed on 37 nodules: mean diameter of 3.1 +/- 0.

View Article and Find Full Text PDF